Ethnic-Specific Genetic Associations with Pulmonary Tuberculosis
Several susceptibility-associated genetic polymorphisms have been proposed to explain differential susceptibility to tuberculosis (TB) disease progression in different populations. Here, polymorphisms in the natural resistance–associated macrophage protein 1 (NRAMP1), vitamin D receptor, tumor necro...
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| Veröffentlicht in: | The Journal of infectious diseases 2002-11, Vol.186 (10), p.1463-1468 |
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| creator | Delgado, Julio C. Baena, Andres Thim, Sok Goldfeld, Anne E. |
| description | Several susceptibility-associated genetic polymorphisms have been proposed to explain differential susceptibility to tuberculosis (TB) disease progression in different populations. Here, polymorphisms in the natural resistance–associated macrophage protein 1 (NRAMP1), vitamin D receptor, tumor necrosis factor–α, interleukin (IL)–1, and IL-10 genes were evaluated in 358 Cambodian patients with pulmonary TB and 106 tuberculin-positive control subjects. Heterozygosity for the −1082 polymorphism of the IL-10 promoter and heterozygosity for 2 linked polymorphic NRAMP1 variants, D543N and 3′ untranslated region, were associated with TB susceptibility and resistance, respectively. Other polymorphisms associated with differential susceptibility to TB were not associated with susceptibility or resistance to TB in Cambodians. The novel pattern of genetic associations with susceptibility and resistance to TB detected in Cambodia is consistent with the conclusion that unique environmental and natural selective factors have resulted in the development of ethnic-specific host genetic factors associated with TB susceptibility and resistance worldwide |
| doi_str_mv | 10.1086/344891 |
| format | Article |
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Here, polymorphisms in the natural resistance–associated macrophage protein 1 (NRAMP1), vitamin D receptor, tumor necrosis factor–α, interleukin (IL)–1, and IL-10 genes were evaluated in 358 Cambodian patients with pulmonary TB and 106 tuberculin-positive control subjects. Heterozygosity for the −1082 polymorphism of the IL-10 promoter and heterozygosity for 2 linked polymorphic NRAMP1 variants, D543N and 3′ untranslated region, were associated with TB susceptibility and resistance, respectively. Other polymorphisms associated with differential susceptibility to TB were not associated with susceptibility or resistance to TB in Cambodians. 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Here, polymorphisms in the natural resistance–associated macrophage protein 1 (NRAMP1), vitamin D receptor, tumor necrosis factor–α, interleukin (IL)–1, and IL-10 genes were evaluated in 358 Cambodian patients with pulmonary TB and 106 tuberculin-positive control subjects. Heterozygosity for the −1082 polymorphism of the IL-10 promoter and heterozygosity for 2 linked polymorphic NRAMP1 variants, D543N and 3′ untranslated region, were associated with TB susceptibility and resistance, respectively. Other polymorphisms associated with differential susceptibility to TB were not associated with susceptibility or resistance to TB in Cambodians. The novel pattern of genetic associations with susceptibility and resistance to TB detected in Cambodia is consistent with the conclusion that unique environmental and natural selective factors have resulted in the development of ethnic-specific host genetic factors associated with TB susceptibility and resistance worldwide</description><subject>Adult</subject><subject>Bacterial diseases</subject><subject>Biological and medical sciences</subject><subject>Cation Transport Proteins - genetics</subject><subject>Disease Susceptibility</subject><subject>Evolutionary genetics</subject><subject>Female</subject><subject>Genetic Predisposition to Disease</subject><subject>Human bacterial diseases</subject><subject>Human genetics</subject><subject>Humans</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Interleukin-1 - genetics</subject><subject>Interleukin-10 - genetics</subject><subject>Major Articles</subject><subject>Male</subject><subject>Medical genetics</subject><subject>Medical sciences</subject><subject>Mycobacterium tuberculosis</subject><subject>Polymorphism, Genetic</subject><subject>Population genetics</subject><subject>Pulmonary tuberculosis</subject><subject>Receptors, Calcitriol - genetics</subject><subject>Tropical medicine</subject><subject>Tuberculin</subject><subject>Tuberculosis</subject><subject>Tuberculosis and atypical mycobacterial infections</subject><subject>Tuberculosis, Pulmonary - ethnology</subject><subject>Tuberculosis, Pulmonary - genetics</subject><subject>Tumor Necrosis Factor-alpha - genetics</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0E1LHEEQBuAmROJq9B8YNoF4G-3v7rlpFqOCEsFNCLk0vT012JvZ6U3XDCb_PiOzuBAInupQD29RLyGHjJ4wavWpkNKW7BWZMCVMoTUTr8mEUs4LZstyl-whLimlUmjzhuwyLqlkmk_I2UX30MZQ3K8hxDqG6SW00A3zHDGF6LuYWpw-xu5hetc3q9T6_Gc67xeQQ98kjPiW7NS-QTjYzH3y9fPFfHZV3Hy5vJ6d3xRBWtYVvNJhuB1AAHjJrAoQrObc8GoRDAOpKw9GaAveyEpYVSmrVWUqJWoN0ot9cjzmrnP61QN2bhUxQNP4FlKPznAtqRbli5BZo6xhZoAf_oHL1Od2eMJxLmxpGKfbtJATYobarXNcDSU4Rt1T825sfoDvNmn9YgXVlm2qHsDHDfAYfFNn34aIWycpN4rbwb0fXerX_z92NJoldik_K0GpVUo-dVCM-4gd_H7e-_zTaSOMclfffzgzu_30zc6Fm4u_OxirvA</recordid><startdate>20021115</startdate><enddate>20021115</enddate><creator>Delgado, Julio C.</creator><creator>Baena, Andres</creator><creator>Thim, Sok</creator><creator>Goldfeld, Anne E.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>20021115</creationdate><title>Ethnic-Specific Genetic Associations with Pulmonary Tuberculosis</title><author>Delgado, Julio C. ; Baena, Andres ; Thim, Sok ; Goldfeld, Anne E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-2d6c367ce3eea4185cec862272dbc71e46dae7368ea74d385d5865d7d53f6e4a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Bacterial diseases</topic><topic>Biological and medical sciences</topic><topic>Cation Transport Proteins - genetics</topic><topic>Disease Susceptibility</topic><topic>Evolutionary genetics</topic><topic>Female</topic><topic>Genetic Predisposition to Disease</topic><topic>Human bacterial diseases</topic><topic>Human genetics</topic><topic>Humans</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Interleukin-1 - genetics</topic><topic>Interleukin-10 - genetics</topic><topic>Major Articles</topic><topic>Male</topic><topic>Medical genetics</topic><topic>Medical sciences</topic><topic>Mycobacterium tuberculosis</topic><topic>Polymorphism, Genetic</topic><topic>Population genetics</topic><topic>Pulmonary tuberculosis</topic><topic>Receptors, Calcitriol - genetics</topic><topic>Tropical medicine</topic><topic>Tuberculin</topic><topic>Tuberculosis</topic><topic>Tuberculosis and atypical mycobacterial infections</topic><topic>Tuberculosis, Pulmonary - ethnology</topic><topic>Tuberculosis, Pulmonary - genetics</topic><topic>Tumor Necrosis Factor-alpha - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Delgado, Julio C.</creatorcontrib><creatorcontrib>Baena, Andres</creatorcontrib><creatorcontrib>Thim, Sok</creatorcontrib><creatorcontrib>Goldfeld, Anne E.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Delgado, Julio C.</au><au>Baena, Andres</au><au>Thim, Sok</au><au>Goldfeld, Anne E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ethnic-Specific Genetic Associations with Pulmonary Tuberculosis</atitle><jtitle>The Journal of infectious diseases</jtitle><stitle>The Journal of Infectious Diseases</stitle><addtitle>The Journal of Infectious Diseases</addtitle><date>2002-11-15</date><risdate>2002</risdate><volume>186</volume><issue>10</issue><spage>1463</spage><epage>1468</epage><pages>1463-1468</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>Several susceptibility-associated genetic polymorphisms have been proposed to explain differential susceptibility to tuberculosis (TB) disease progression in different populations. Here, polymorphisms in the natural resistance–associated macrophage protein 1 (NRAMP1), vitamin D receptor, tumor necrosis factor–α, interleukin (IL)–1, and IL-10 genes were evaluated in 358 Cambodian patients with pulmonary TB and 106 tuberculin-positive control subjects. Heterozygosity for the −1082 polymorphism of the IL-10 promoter and heterozygosity for 2 linked polymorphic NRAMP1 variants, D543N and 3′ untranslated region, were associated with TB susceptibility and resistance, respectively. Other polymorphisms associated with differential susceptibility to TB were not associated with susceptibility or resistance to TB in Cambodians. The novel pattern of genetic associations with susceptibility and resistance to TB detected in Cambodia is consistent with the conclusion that unique environmental and natural selective factors have resulted in the development of ethnic-specific host genetic factors associated with TB susceptibility and resistance worldwide</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>12404162</pmid><doi>10.1086/344891</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Adult Bacterial diseases Biological and medical sciences Cation Transport Proteins - genetics Disease Susceptibility Evolutionary genetics Female Genetic Predisposition to Disease Human bacterial diseases Human genetics Humans Infections Infectious diseases Interleukin-1 - genetics Interleukin-10 - genetics Major Articles Male Medical genetics Medical sciences Mycobacterium tuberculosis Polymorphism, Genetic Population genetics Pulmonary tuberculosis Receptors, Calcitriol - genetics Tropical medicine Tuberculin Tuberculosis Tuberculosis and atypical mycobacterial infections Tuberculosis, Pulmonary - ethnology Tuberculosis, Pulmonary - genetics Tumor Necrosis Factor-alpha - genetics |
| title | Ethnic-Specific Genetic Associations with Pulmonary Tuberculosis |
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