Synaptic glutamate receptor clustering in mice lacking the SH3 and GK domains of SAP97

Postsynaptic targeting of the Drosophila tumour suppressor discs‐large (Dlg) critically depends on its SH3 and GK domains. Here, we asked whether these domains are also involved in subcellular targeting of the mammalian Dlg homolog SAP97 and its interacting partners in CNS cortical neurons by analys...

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Veröffentlicht in:	The European journal of neuroscience 2002-10, Vol.16 (8), p.1517-1522
Hauptverfasser:	Klöcker, Nikolaj, Bunn, Robert C., Schnell, Eric, Caruana, Georgina, Bernstein, Alan, Nicoll, Roger A., Bredt, David S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing AMPA receptors Animals Cell Compartmentation - genetics Cell Differentiation - genetics Cells, Cultured Cerebral Cortex - abnormalities Cerebral Cortex - cytology Cerebral Cortex - metabolism Dendrites - genetics Dendrites - metabolism Dendrites - ultrastructure Discs Large Homolog 1 Protein Drosophila Endoplasmic Reticulum - metabolism Endoplasmic Reticulum - ultrastructure GKAP Guanylate Kinases Immunohistochemistry MAGUK Membrane Proteins Mice Mice, Transgenic Mutation - genetics Nerve Tissue Proteins - deficiency Nerve Tissue Proteins - genetics Neurons - cytology Neurons - metabolism Protein Structure, Tertiary - genetics Protein Transport - genetics Receptors, AMPA - genetics Receptors, AMPA - metabolism subcellular localization Synapses - genetics Synapses - metabolism
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