Talin Is Essential for Integrin Function in Drosophila

We show that the Drosophila gene rhea, isolated because its wing blister phenotype is typical of mutants affecting integrin function, encodes talin. Embryos deficient in talin have very similar phenotypes to integrin (βPS) null embryos, including failure in germ band retraction and muscle detachment...

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Veröffentlicht in:	Developmental cell 2002-10, Vol.3 (4), p.569-579
Hauptverfasser:	Brown, Nicholas H., Gregory, Stephen L., Rickoll, Wayne L., Fessler, Liselotte I., Prout, Mary, White, Robert A.H., Fristrom, James W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Adhesion - genetics Cytoskeleton - genetics Drosophila - embryology Drosophila - genetics Embryo, Nonmammalian - embryology Embryo, Nonmammalian - physiology Extracellular Matrix - genetics Integrins - genetics Talin - genetics
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