Talin Is Essential for Integrin Function in Drosophila
We show that the Drosophila gene rhea, isolated because its wing blister phenotype is typical of mutants affecting integrin function, encodes talin. Embryos deficient in talin have very similar phenotypes to integrin (βPS) null embryos, including failure in germ band retraction and muscle detachment...
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| Veröffentlicht in: | Developmental cell 2002-10, Vol.3 (4), p.569-579 |
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| container_title | Developmental cell |
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| creator | Brown, Nicholas H. Gregory, Stephen L. Rickoll, Wayne L. Fessler, Liselotte I. Prout, Mary White, Robert A.H. Fristrom, James W. |
| description | We show that the
Drosophila gene
rhea, isolated because its wing blister phenotype is typical of mutants affecting integrin function, encodes talin. Embryos deficient in talin have very similar phenotypes to integrin (βPS) null embryos, including failure in germ band retraction and muscle detachment. We demonstrate that talin is not required for the presence of integrins on the cell surface or their localization at muscle termini. However, talin is required for formation of focal adhesion-like clusters of integrins on the basal surface of imaginal disc epithelia and junctional plaques between muscle and tendon cells. These results indicate that talin is essential for integrin function and acts by stably linking clusters of ECM-linked integrins to the cytoskeleton. |
| doi_str_mv | 10.1016/S1534-5807(02)00290-3 |
| format | Article |
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Drosophila gene
rhea, isolated because its wing blister phenotype is typical of mutants affecting integrin function, encodes talin. Embryos deficient in talin have very similar phenotypes to integrin (βPS) null embryos, including failure in germ band retraction and muscle detachment. We demonstrate that talin is not required for the presence of integrins on the cell surface or their localization at muscle termini. However, talin is required for formation of focal adhesion-like clusters of integrins on the basal surface of imaginal disc epithelia and junctional plaques between muscle and tendon cells. These results indicate that talin is essential for integrin function and acts by stably linking clusters of ECM-linked integrins to the cytoskeleton.</description><identifier>ISSN: 1534-5807</identifier><identifier>EISSN: 1878-1551</identifier><identifier>DOI: 10.1016/S1534-5807(02)00290-3</identifier><identifier>PMID: 12408808</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Cell Adhesion - genetics ; Cytoskeleton - genetics ; Drosophila - embryology ; Drosophila - genetics ; Embryo, Nonmammalian - embryology ; Embryo, Nonmammalian - physiology ; Extracellular Matrix - genetics ; Integrins - genetics ; Talin - genetics</subject><ispartof>Developmental cell, 2002-10, Vol.3 (4), p.569-579</ispartof><rights>2002 Cell Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c557t-36b3915d0a231fe9b015fb7d14384c73e924377d37b507b333f273c752e432303</citedby><cites>FETCH-LOGICAL-c557t-36b3915d0a231fe9b015fb7d14384c73e924377d37b507b333f273c752e432303</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S1534-5807(02)00290-3$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12408808$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Brown, Nicholas H.</creatorcontrib><creatorcontrib>Gregory, Stephen L.</creatorcontrib><creatorcontrib>Rickoll, Wayne L.</creatorcontrib><creatorcontrib>Fessler, Liselotte I.</creatorcontrib><creatorcontrib>Prout, Mary</creatorcontrib><creatorcontrib>White, Robert A.H.</creatorcontrib><creatorcontrib>Fristrom, James W.</creatorcontrib><title>Talin Is Essential for Integrin Function in Drosophila</title><title>Developmental cell</title><addtitle>Dev Cell</addtitle><description>We show that the
Drosophila gene
rhea, isolated because its wing blister phenotype is typical of mutants affecting integrin function, encodes talin. Embryos deficient in talin have very similar phenotypes to integrin (βPS) null embryos, including failure in germ band retraction and muscle detachment. We demonstrate that talin is not required for the presence of integrins on the cell surface or their localization at muscle termini. However, talin is required for formation of focal adhesion-like clusters of integrins on the basal surface of imaginal disc epithelia and junctional plaques between muscle and tendon cells. These results indicate that talin is essential for integrin function and acts by stably linking clusters of ECM-linked integrins to the cytoskeleton.</description><subject>Animals</subject><subject>Cell Adhesion - genetics</subject><subject>Cytoskeleton - genetics</subject><subject>Drosophila - embryology</subject><subject>Drosophila - genetics</subject><subject>Embryo, Nonmammalian - embryology</subject><subject>Embryo, Nonmammalian - physiology</subject><subject>Extracellular Matrix - genetics</subject><subject>Integrins - genetics</subject><subject>Talin - genetics</subject><issn>1534-5807</issn><issn>1878-1551</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1PwzAMhiMEYmPwE0A9ITgU7Lhp0hNC42vSJA7AOWrTFIK6diQdEv-ejA1x5GRLfl5bfhg7RrhAwPzyCQVlqVAgz4CfA_ACUtphY1RSpSgE7sb-FxmxgxDeIeZQwT4bIc9AKVBjlj-XreuSWUhuQ7Dd4Mo2aXqfzLrBvvo4uVt1ZnB9l8T-xvehX765tjxke03ZBnu0rRP2cnf7PH1I54_3s-n1PDVCyCGlvKICRQ0lJ2xsUQGKppI1ZqQyI8kWPCMpa5KVAFkRUcMlGSm4zYgT0ISdbvYuff-xsmHQCxeMbduys_0qaMlzUrIQ_4KoRJHnAiMoNqCJzwRvG730blH6L42g12b1j1m91qaB6x-zmmLuZHtgVS1s_ZfaqozA1Qaw0cens14H42xnbO28NYOue_fPiW9maYUx</recordid><startdate>20021001</startdate><enddate>20021001</enddate><creator>Brown, Nicholas H.</creator><creator>Gregory, Stephen L.</creator><creator>Rickoll, Wayne L.</creator><creator>Fessler, Liselotte I.</creator><creator>Prout, Mary</creator><creator>White, Robert A.H.</creator><creator>Fristrom, James W.</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20021001</creationdate><title>Talin Is Essential for Integrin Function in Drosophila</title><author>Brown, Nicholas H. ; Gregory, Stephen L. ; Rickoll, Wayne L. ; Fessler, Liselotte I. ; Prout, Mary ; White, Robert A.H. ; Fristrom, James W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c557t-36b3915d0a231fe9b015fb7d14384c73e924377d37b507b333f273c752e432303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Cell Adhesion - genetics</topic><topic>Cytoskeleton - genetics</topic><topic>Drosophila - embryology</topic><topic>Drosophila - genetics</topic><topic>Embryo, Nonmammalian - embryology</topic><topic>Embryo, Nonmammalian - physiology</topic><topic>Extracellular Matrix - genetics</topic><topic>Integrins - genetics</topic><topic>Talin - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brown, Nicholas H.</creatorcontrib><creatorcontrib>Gregory, Stephen L.</creatorcontrib><creatorcontrib>Rickoll, Wayne L.</creatorcontrib><creatorcontrib>Fessler, Liselotte I.</creatorcontrib><creatorcontrib>Prout, Mary</creatorcontrib><creatorcontrib>White, Robert A.H.</creatorcontrib><creatorcontrib>Fristrom, James W.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Developmental cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brown, Nicholas H.</au><au>Gregory, Stephen L.</au><au>Rickoll, Wayne L.</au><au>Fessler, Liselotte I.</au><au>Prout, Mary</au><au>White, Robert A.H.</au><au>Fristrom, James W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Talin Is Essential for Integrin Function in Drosophila</atitle><jtitle>Developmental cell</jtitle><addtitle>Dev Cell</addtitle><date>2002-10-01</date><risdate>2002</risdate><volume>3</volume><issue>4</issue><spage>569</spage><epage>579</epage><pages>569-579</pages><issn>1534-5807</issn><eissn>1878-1551</eissn><abstract>We show that the
Drosophila gene
rhea, isolated because its wing blister phenotype is typical of mutants affecting integrin function, encodes talin. Embryos deficient in talin have very similar phenotypes to integrin (βPS) null embryos, including failure in germ band retraction and muscle detachment. We demonstrate that talin is not required for the presence of integrins on the cell surface or their localization at muscle termini. However, talin is required for formation of focal adhesion-like clusters of integrins on the basal surface of imaginal disc epithelia and junctional plaques between muscle and tendon cells. These results indicate that talin is essential for integrin function and acts by stably linking clusters of ECM-linked integrins to the cytoskeleton.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>12408808</pmid><doi>10.1016/S1534-5807(02)00290-3</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Cell Press Free Archives; Access via ScienceDirect (Elsevier); EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Cell Adhesion - genetics Cytoskeleton - genetics Drosophila - embryology Drosophila - genetics Embryo, Nonmammalian - embryology Embryo, Nonmammalian - physiology Extracellular Matrix - genetics Integrins - genetics Talin - genetics |
| title | Talin Is Essential for Integrin Function in Drosophila |
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