Functional PPAR-γ receptor is a novel therapeutic target for ACTH-secreting pituitary adenomas

Adrenocorticotrophic hormone (ACTH)-secreting pituitary tumors are associated with high morbidity due to excess glucocorticoid production. No suitable drug therapies are currently available, and surgical excision is not invariably curative. Here we demonstrate immunoreactive expression of the nuclea...

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Veröffentlicht in:	Nature medicine 2002-11, Vol.8 (11), p.1281-1287
Hauptverfasser:	Heaney, Anthony P., Fernando, Manory, Yong, William H., Melmed, Shlomo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Glands - physiopathology Adrenocorticotropic Hormone - secretion Animals Biomedical and Life Sciences Biomedicine Cancer Research Cell Division - drug effects Cushing Syndrome - drug therapy Female Humans Infectious Diseases Ligands Metabolic Diseases Mice Mice, Nude Molecular Medicine Neoplasm Proteins - genetics Neoplasm Transplantation Neurosciences Pituitary Gland - physiopathology Pituitary Neoplasms - drug therapy Pituitary Neoplasms - pathology Pituitary Neoplasms - physiopathology Pituitary Neoplasms - secretion Pro-Opiomelanocortin - genetics Receptors, Cytoplasmic and Nuclear - drug effects Receptors, Cytoplasmic and Nuclear - metabolism Securin Transcription Factors - drug effects Transcription Factors - metabolism
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