Mechanism of incomplete mitral leaflet coaptation: Interaction of chordal restraint and changes in mitral leaflet coaptation geometry insight from in vitro validation of the premise of force equilibrium

Clinically observed incomplete mitral leaflet coaptation was reproduced in vitro by altering the balance of the chordal tethering and chordal coapting force components. Mitral leaflet coaptation geometry was distorted by changes of the spatial relations between the papillary muscles and the mitral v...

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Veröffentlicht in:	Journal of biomechanical engineering 2002-10, Vol.124 (5), p.596-608
Hauptverfasser:	NIELSER, Sten Lyager, NYGAARD, Hans, MANDRUP, Lars, FONTAINE, Arnold A, HASENKAM, J. Michael, SHENGQUI HE, YOGANATHAN, Ajit P
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation, Physiological Animals Biological and medical sciences Chordae Tendineae - diagnostic imaging Chordae Tendineae - physiopathology Echocardiography In Vitro Techniques Medical sciences Mitral Valve - anatomy & histology Mitral Valve - diagnostic imaging Mitral Valve - physiopathology Mitral Valve Insufficiency - diagnostic imaging Mitral Valve Insufficiency - physiopathology Models, Cardiovascular Papillary Muscles - diagnostic imaging Papillary Muscles - physiopathology Postural Balance Pressure Reproducibility of Results Sensitivity and Specificity Stress, Mechanical Swine Systole - physiology Ventricular Remodeling
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