In vivo neurochemical monitoring by microdialysis and capillary separations
Microdialysis is valuable for studying the neurochemical changes underlying behavior. Recent advances include the application of the high-sensitivity methods of capillary electrophoresis and capillary liquid chromatography with mass spectrometry to dialysate analysis. These methods have improved tem...
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| Veröffentlicht in: | Current Opinion in Chemical Biology 2002-10, Vol.6 (5), p.659-665 |
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| container_end_page | 665 |
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| container_title | Current Opinion in Chemical Biology |
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| creator | Kennedy, Robert T Watson, Christopher J Haskins, William E Powell, David H Strecker, Robert E |
| description | Microdialysis is valuable for studying the neurochemical changes underlying behavior. Recent advances include the application of the high-sensitivity methods of capillary electrophoresis and capillary liquid chromatography with mass spectrometry to dialysate analysis. These methods have improved temporal resolution, spatial resolution, multi-analyte capability and potential for compound discovery.
Advances in neurochemical monitoring based on high-sensitivity methods and novel approaches to compound discovery are revealing the chemical basis of behavior and identifying pharmacological targets for mental illness treatments. |
| doi_str_mv | 10.1016/S1367-5931(02)00373-3 |
| format | Article |
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Advances in neurochemical monitoring based on high-sensitivity methods and novel approaches to compound discovery are revealing the chemical basis of behavior and identifying pharmacological targets for mental illness treatments.</description><subject>Animals</subject><subject>behaviors</subject><subject>Brain Chemistry</subject><subject>capillary electrophoresis</subject><subject>capillary liquid chromatography</subject><subject>Chromatography, High Pressure Liquid - methods</subject><subject>Electrophoresis, Capillary</subject><subject>Humans</subject><subject>Microdialysis</subject><subject>Neuropeptides - analysis</subject><subject>Neuropeptides - chemistry</subject><subject>proteomics</subject><subject>Sensitivity and Specificity</subject><subject>Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods</subject><issn>1367-5931</issn><issn>1879-0402</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMlOwzAQQC0EoqXwCaCcEBwC4y3LCaGKpaISB-Bsuc4EjJK42Gml_j3ugjjCyePRm-0RckrhigLNrl8oz_JUlpxeALsE4DlP-R4Z0iIvUxDA9mP8gwzIUQifAJCxQh6SAWWCcinpkDxNumRply7pcOGd-cDWGt0krets77zt3pPZKok57yqrm1WwIdFdlRg9t02j_SoJONde99Z14Zgc1LoJeLJ7R-Tt_u51_JhOnx8m49tpanjJ-rQCkNrU642NmMlK57IUvK5p_DOUWmiGeYEllVyU2jBTZ4KyWcFBIOSZ4CNyvu079-5rgaFXrQ0G4z4dukVQOct4Tv8B0iKjIKKKEZFbMN4Zgsdazb1t43mKglrrVhvdau1SAVMb3YrHurPdgMWsxeq3auc3AjdbAKOPpUWvgrHYGaysR9Orytk_RnwD6jqPMw</recordid><startdate>20021001</startdate><enddate>20021001</enddate><creator>Kennedy, Robert T</creator><creator>Watson, Christopher J</creator><creator>Haskins, William E</creator><creator>Powell, David H</creator><creator>Strecker, Robert E</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20021001</creationdate><title>In vivo neurochemical monitoring by microdialysis and capillary separations</title><author>Kennedy, Robert T ; Watson, Christopher J ; Haskins, William E ; Powell, David H ; Strecker, Robert E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c392t-d005acf0373c4b5da75943ff173c2e5a4a2e78e915349ac2cf6412b8304e07643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>behaviors</topic><topic>Brain Chemistry</topic><topic>capillary electrophoresis</topic><topic>capillary liquid chromatography</topic><topic>Chromatography, High Pressure Liquid - methods</topic><topic>Electrophoresis, Capillary</topic><topic>Humans</topic><topic>Microdialysis</topic><topic>Neuropeptides - analysis</topic><topic>Neuropeptides - chemistry</topic><topic>proteomics</topic><topic>Sensitivity and Specificity</topic><topic>Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kennedy, Robert T</creatorcontrib><creatorcontrib>Watson, Christopher J</creatorcontrib><creatorcontrib>Haskins, William E</creatorcontrib><creatorcontrib>Powell, David H</creatorcontrib><creatorcontrib>Strecker, Robert E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Current Opinion in Chemical Biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kennedy, Robert T</au><au>Watson, Christopher J</au><au>Haskins, William E</au><au>Powell, David H</au><au>Strecker, Robert E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vivo neurochemical monitoring by microdialysis and capillary separations</atitle><jtitle>Current Opinion in Chemical Biology</jtitle><addtitle>Curr Opin Chem Biol</addtitle><date>2002-10-01</date><risdate>2002</risdate><volume>6</volume><issue>5</issue><spage>659</spage><epage>665</epage><pages>659-665</pages><issn>1367-5931</issn><eissn>1879-0402</eissn><abstract>Microdialysis is valuable for studying the neurochemical changes underlying behavior. Recent advances include the application of the high-sensitivity methods of capillary electrophoresis and capillary liquid chromatography with mass spectrometry to dialysate analysis. These methods have improved temporal resolution, spatial resolution, multi-analyte capability and potential for compound discovery.
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| ispartof | Current Opinion in Chemical Biology, 2002-10, Vol.6 (5), p.659-665 |
| issn | 1367-5931 1879-0402 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals behaviors Brain Chemistry capillary electrophoresis capillary liquid chromatography Chromatography, High Pressure Liquid - methods Electrophoresis, Capillary Humans Microdialysis Neuropeptides - analysis Neuropeptides - chemistry proteomics Sensitivity and Specificity Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods |
| title | In vivo neurochemical monitoring by microdialysis and capillary separations |
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