Wnt glycoproteins regulate the expression of FoxN1, the gene defective in nude mice

T cell development and selection require the fully mature and diverse epithelial microenvironment of the thymus. Acquisition of these characteristics is dependent on expression of the forkhead (also known as winged-helix) transcription factor FoxN1, as a lack of functional FoxN1 results in aberrant...

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Veröffentlicht in:	Nature immunology 2002-11, Vol.3 (11), p.1102-1108
Hauptverfasser:	Balciunaite, Gina, Keller, Marcel P., Balciunaite, Egle, Piali, Luca, Zuklys, Saulius, Mathieu, Yves D., Gill, Jason, Boyd, Richard, Sussman, Daniel J., Holländer, Georg A.
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Adaptor Proteins, Signal Transducing Animals Autocrine Communication beta Catenin Biomedical and Life Sciences Biomedicine Cell Differentiation Chromones - pharmacology Cytoskeletal Proteins - biosynthesis Cytoskeletal Proteins - genetics Dishevelled Proteins DNA-Binding Proteins - biosynthesis DNA-Binding Proteins - deficiency DNA-Binding Proteins - genetics Enzyme Inhibitors - pharmacology Epithelial Cells - metabolism Epithelial Cells - ultrastructure Forkhead Transcription Factors Gene Expression Regulation Genes, Reporter Glycoproteins Glycoproteins - biosynthesis Glycoproteins - genetics Glycoproteins - physiology Immunology Infectious Diseases Lymphoid Enhancer-Binding Factor 1 Lymphopoiesis - genetics Mice Mice, Nude Morphogenesis Morpholines - pharmacology Paracrine Communication Phosphatidylinositol 3-Kinases - antagonists & inhibitors Phosphatidylinositol 3-Kinases - physiology Phosphoproteins - biosynthesis Phosphoproteins - genetics Phosphorylation Protein Biosynthesis Protein Processing, Post-Translational Protein-Serine-Threonine Kinases Proteins - genetics Proteins - physiology Proto-Oncogene Proteins - biosynthesis Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins - physiology Proto-Oncogene Proteins c-akt Receptors, Cell Surface - biosynthesis Receptors, Cell Surface - genetics Receptors, G-Protein-Coupled Recombinant Fusion Proteins - physiology T-Lymphocytes - cytology TCF Transcription Factors Thymus Gland - cytology Thymus Gland - metabolism Trans-Activators - biosynthesis Trans-Activators - genetics Transcription Factor 7-Like 2 Protein Transcription Factors - biosynthesis Transcription Factors - deficiency Transcription Factors - genetics Transcription Factors - physiology Transcription, Genetic Wnt Proteins Wnt3 Protein Wnt4 Protein Xenopus Proteins Zebrafish Proteins
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