Wnt glycoproteins regulate the expression of FoxN1, the gene defective in nude mice
T cell development and selection require the fully mature and diverse epithelial microenvironment of the thymus. Acquisition of these characteristics is dependent on expression of the forkhead (also known as winged-helix) transcription factor FoxN1, as a lack of functional FoxN1 results in aberrant...
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| Veröffentlicht in: | Nature immunology 2002-11, Vol.3 (11), p.1102-1108 |
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| container_title | Nature immunology |
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| creator | Balciunaite, Gina Keller, Marcel P. Balciunaite, Egle Piali, Luca Zuklys, Saulius Mathieu, Yves D. Gill, Jason Boyd, Richard Sussman, Daniel J. Holländer, Georg A. |
| description | T cell development and selection require the fully mature and diverse epithelial microenvironment of the thymus. Acquisition of these characteristics is dependent on expression of the forkhead (also known as winged-helix) transcription factor FoxN1, as a lack of functional FoxN1 results in aberrant epithelial morphogenesis and an inability to attract lymphoid precursors to the thymus primordium. However, the transcriptional control of
Foxn1
expression has not been elucidated. Here we report that secreted Wnt glycoproteins, expressed by thymic epithelial cells and thymocytes, regulate epithelial
Foxn1
expression in both autocrine and paracrine fashions. Wnt molecules therefore provide regulatory signals critical for thymic function. |
| doi_str_mv | 10.1038/ni850 |
| format | Article |
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Foxn1
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Foxn1
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Foxn1
expression has not been elucidated. Here we report that secreted Wnt glycoproteins, expressed by thymic epithelial cells and thymocytes, regulate epithelial
Foxn1
expression in both autocrine and paracrine fashions. Wnt molecules therefore provide regulatory signals critical for thymic function.</description><subject>3T3 Cells</subject><subject>Adaptor Proteins, Signal Transducing</subject><subject>Animals</subject><subject>Autocrine Communication</subject><subject>beta Catenin</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Differentiation</subject><subject>Chromones - pharmacology</subject><subject>Cytoskeletal Proteins - biosynthesis</subject><subject>Cytoskeletal Proteins - genetics</subject><subject>Dishevelled Proteins</subject><subject>DNA-Binding Proteins - biosynthesis</subject><subject>DNA-Binding Proteins - deficiency</subject><subject>DNA-Binding Proteins - genetics</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>Epithelial Cells - metabolism</subject><subject>Epithelial Cells - ultrastructure</subject><subject>Forkhead Transcription Factors</subject><subject>Gene Expression Regulation</subject><subject>Genes, Reporter</subject><subject>Glycoproteins</subject><subject>Glycoproteins - biosynthesis</subject><subject>Glycoproteins - genetics</subject><subject>Glycoproteins - physiology</subject><subject>Immunology</subject><subject>Infectious Diseases</subject><subject>Lymphoid Enhancer-Binding Factor 1</subject><subject>Lymphopoiesis - genetics</subject><subject>Mice</subject><subject>Mice, Nude</subject><subject>Morphogenesis</subject><subject>Morpholines - pharmacology</subject><subject>Paracrine Communication</subject><subject>Phosphatidylinositol 3-Kinases - antagonists & inhibitors</subject><subject>Phosphatidylinositol 3-Kinases - physiology</subject><subject>Phosphoproteins - biosynthesis</subject><subject>Phosphoproteins - genetics</subject><subject>Phosphorylation</subject><subject>Protein Biosynthesis</subject><subject>Protein Processing, Post-Translational</subject><subject>Protein-Serine-Threonine Kinases</subject><subject>Proteins - genetics</subject><subject>Proteins - physiology</subject><subject>Proto-Oncogene Proteins - biosynthesis</subject><subject>Proto-Oncogene Proteins - genetics</subject><subject>Proto-Oncogene Proteins - metabolism</subject><subject>Proto-Oncogene Proteins - physiology</subject><subject>Proto-Oncogene Proteins c-akt</subject><subject>Receptors, Cell Surface - biosynthesis</subject><subject>Receptors, Cell Surface - genetics</subject><subject>Receptors, G-Protein-Coupled</subject><subject>Recombinant Fusion Proteins - physiology</subject><subject>T-Lymphocytes - cytology</subject><subject>TCF Transcription Factors</subject><subject>Thymus Gland - cytology</subject><subject>Thymus Gland - metabolism</subject><subject>Trans-Activators - biosynthesis</subject><subject>Trans-Activators - genetics</subject><subject>Transcription Factor 7-Like 2 Protein</subject><subject>Transcription Factors - biosynthesis</subject><subject>Transcription Factors - deficiency</subject><subject>Transcription Factors - genetics</subject><subject>Transcription Factors - physiology</subject><subject>Transcription, Genetic</subject><subject>Wnt Proteins</subject><subject>Wnt3 Protein</subject><subject>Wnt4 Protein</subject><subject>Xenopus Proteins</subject><subject>Zebrafish Proteins</subject><issn>1529-2908</issn><issn>1529-2916</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkVFrFDEQx4NYbG37FSQIFgSvJrubbPJYitVCUbAVH0M2mawpe8mZZOX67U17R4_zReYhw8xvhvnnj9ApJeeUtOJj8IKRF-iIskYuGkn5y-eciEP0Oud7QmjX8-4VOqRN20vB6BG6_RkKHqcHE1cpFvAh4wTjPOkCuPwCDOtVgpx9DDg6fBXXX-mHp8YIAbAFB6b4P4B9wGG2gJfewAk6cHrKcLp9j9GPq093l18WN98-X19e3CxM2wmy4IMUtLMDJ4OW2hIG1gyOS-sIb5xhHdBeyl46q1ktMNn3jDtoBmvdwFrbHqOzzd56-u8ZclFLnw1Mkw4Q56z6hrdcNOK_IBW8pZQ8gm__Ae_jnEIVoZqm_h5hjFTofAONegLlg4slaVPDQlUfAzhf6xdUCEF413Z14P3eQGUKrMuo55zV9e33ffbdhjUp5pzAqVXyS50eFCXq0Wj1ZHTl3mwvnYcl2B21dXanOddWGCHtpOxv-guQN62V</recordid><startdate>20021101</startdate><enddate>20021101</enddate><creator>Balciunaite, Gina</creator><creator>Keller, Marcel P.</creator><creator>Balciunaite, Egle</creator><creator>Piali, Luca</creator><creator>Zuklys, Saulius</creator><creator>Mathieu, Yves D.</creator><creator>Gill, Jason</creator><creator>Boyd, Richard</creator><creator>Sussman, Daniel J.</creator><creator>Holländer, Georg A.</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>3V.</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20021101</creationdate><title>Wnt glycoproteins regulate the expression of FoxN1, the gene defective in nude mice</title><author>Balciunaite, Gina ; Keller, Marcel P. ; Balciunaite, Egle ; Piali, Luca ; Zuklys, Saulius ; Mathieu, Yves D. ; Gill, Jason ; Boyd, Richard ; Sussman, Daniel J. ; Holländer, Georg A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3480-6b9814db60ba9ad05edcbf69df062fc54e179979fda562f597756fe2bddfb53d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>3T3 Cells</topic><topic>Adaptor Proteins, Signal Transducing</topic><topic>Animals</topic><topic>Autocrine Communication</topic><topic>beta Catenin</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cell Differentiation</topic><topic>Chromones - pharmacology</topic><topic>Cytoskeletal Proteins - biosynthesis</topic><topic>Cytoskeletal Proteins - genetics</topic><topic>Dishevelled Proteins</topic><topic>DNA-Binding Proteins - biosynthesis</topic><topic>DNA-Binding Proteins - deficiency</topic><topic>DNA-Binding Proteins - genetics</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>Epithelial Cells - metabolism</topic><topic>Epithelial Cells - ultrastructure</topic><topic>Forkhead Transcription Factors</topic><topic>Gene Expression Regulation</topic><topic>Genes, Reporter</topic><topic>Glycoproteins</topic><topic>Glycoproteins - biosynthesis</topic><topic>Glycoproteins - genetics</topic><topic>Glycoproteins - physiology</topic><topic>Immunology</topic><topic>Infectious Diseases</topic><topic>Lymphoid Enhancer-Binding Factor 1</topic><topic>Lymphopoiesis - genetics</topic><topic>Mice</topic><topic>Mice, Nude</topic><topic>Morphogenesis</topic><topic>Morpholines - pharmacology</topic><topic>Paracrine Communication</topic><topic>Phosphatidylinositol 3-Kinases - 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biosynthesis</topic><topic>Trans-Activators - genetics</topic><topic>Transcription Factor 7-Like 2 Protein</topic><topic>Transcription Factors - biosynthesis</topic><topic>Transcription Factors - deficiency</topic><topic>Transcription Factors - genetics</topic><topic>Transcription Factors - physiology</topic><topic>Transcription, Genetic</topic><topic>Wnt Proteins</topic><topic>Wnt3 Protein</topic><topic>Wnt4 Protein</topic><topic>Xenopus Proteins</topic><topic>Zebrafish Proteins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Balciunaite, Gina</creatorcontrib><creatorcontrib>Keller, Marcel P.</creatorcontrib><creatorcontrib>Balciunaite, Egle</creatorcontrib><creatorcontrib>Piali, Luca</creatorcontrib><creatorcontrib>Zuklys, Saulius</creatorcontrib><creatorcontrib>Mathieu, Yves D.</creatorcontrib><creatorcontrib>Gill, Jason</creatorcontrib><creatorcontrib>Boyd, Richard</creatorcontrib><creatorcontrib>Sussman, Daniel J.</creatorcontrib><creatorcontrib>Holländer, Georg A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Nature immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Balciunaite, Gina</au><au>Keller, Marcel P.</au><au>Balciunaite, Egle</au><au>Piali, Luca</au><au>Zuklys, Saulius</au><au>Mathieu, Yves D.</au><au>Gill, Jason</au><au>Boyd, Richard</au><au>Sussman, Daniel J.</au><au>Holländer, Georg A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Wnt glycoproteins regulate the expression of FoxN1, the gene defective in nude mice</atitle><jtitle>Nature immunology</jtitle><stitle>Nat Immunol</stitle><addtitle>Nat Immunol</addtitle><date>2002-11-01</date><risdate>2002</risdate><volume>3</volume><issue>11</issue><spage>1102</spage><epage>1108</epage><pages>1102-1108</pages><issn>1529-2908</issn><eissn>1529-2916</eissn><abstract>T cell development and selection require the fully mature and diverse epithelial microenvironment of the thymus. Acquisition of these characteristics is dependent on expression of the forkhead (also known as winged-helix) transcription factor FoxN1, as a lack of functional FoxN1 results in aberrant epithelial morphogenesis and an inability to attract lymphoid precursors to the thymus primordium. However, the transcriptional control of
Foxn1
expression has not been elucidated. Here we report that secreted Wnt glycoproteins, expressed by thymic epithelial cells and thymocytes, regulate epithelial
Foxn1
expression in both autocrine and paracrine fashions. Wnt molecules therefore provide regulatory signals critical for thymic function.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>12379851</pmid><doi>10.1038/ni850</doi><tpages>7</tpages></addata></record> |
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| ispartof | Nature immunology, 2002-11, Vol.3 (11), p.1102-1108 |
| issn | 1529-2908 1529-2916 |
| language | eng |
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| source | MEDLINE; Nature; SpringerLink Journals - AutoHoldings |
| subjects | 3T3 Cells Adaptor Proteins, Signal Transducing Animals Autocrine Communication beta Catenin Biomedical and Life Sciences Biomedicine Cell Differentiation Chromones - pharmacology Cytoskeletal Proteins - biosynthesis Cytoskeletal Proteins - genetics Dishevelled Proteins DNA-Binding Proteins - biosynthesis DNA-Binding Proteins - deficiency DNA-Binding Proteins - genetics Enzyme Inhibitors - pharmacology Epithelial Cells - metabolism Epithelial Cells - ultrastructure Forkhead Transcription Factors Gene Expression Regulation Genes, Reporter Glycoproteins Glycoproteins - biosynthesis Glycoproteins - genetics Glycoproteins - physiology Immunology Infectious Diseases Lymphoid Enhancer-Binding Factor 1 Lymphopoiesis - genetics Mice Mice, Nude Morphogenesis Morpholines - pharmacology Paracrine Communication Phosphatidylinositol 3-Kinases - antagonists & inhibitors Phosphatidylinositol 3-Kinases - physiology Phosphoproteins - biosynthesis Phosphoproteins - genetics Phosphorylation Protein Biosynthesis Protein Processing, Post-Translational Protein-Serine-Threonine Kinases Proteins - genetics Proteins - physiology Proto-Oncogene Proteins - biosynthesis Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins - physiology Proto-Oncogene Proteins c-akt Receptors, Cell Surface - biosynthesis Receptors, Cell Surface - genetics Receptors, G-Protein-Coupled Recombinant Fusion Proteins - physiology T-Lymphocytes - cytology TCF Transcription Factors Thymus Gland - cytology Thymus Gland - metabolism Trans-Activators - biosynthesis Trans-Activators - genetics Transcription Factor 7-Like 2 Protein Transcription Factors - biosynthesis Transcription Factors - deficiency Transcription Factors - genetics Transcription Factors - physiology Transcription, Genetic Wnt Proteins Wnt3 Protein Wnt4 Protein Xenopus Proteins Zebrafish Proteins |
| title | Wnt glycoproteins regulate the expression of FoxN1, the gene defective in nude mice |
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