NADH Model Systems Functionalized with Zn(II)-Cyclen as Flavin Binding SiteStructure Dependence of the Redox Reaction within Reversible Aggregates

The relative positions and conformations of the prosthetic group FAD and the cofactor NADH have been remarkably conserved within the structurally diverse group of flavin enzymes. To provide a chemical rational for such an obviously optimal relative disposition of the redox partners for efficient rea...

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Veröffentlicht in:	Journal of the American Chemical Society 2002-11, Vol.124 (44), p.12999-13007
Hauptverfasser:	Reichenbach-Klinke, Roland, Kruppa, Michael, König, Burkhard
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical chemistry Atomic and molecular physics Binding Sites Chemistry Exact sciences and technology Flavins - chemistry Flavins - metabolism General molecular conformation and symmetry stereochemistry Heterocyclic Compounds - chemistry Kinetics Models, Molecular Molecular properties and interactions with photons NAD - chemistry NAD - metabolism Organometallic Compounds - chemistry Oxidation-Reduction Physics Potentiometry Properties of molecules and molecular ions Riboflavin - analogs & derivatives Riboflavin - chemistry Riboflavin - metabolism Spectrometric and optical methods Spectrophotometry, Ultraviolet Structure-Activity Relationship Zinc - chemistry
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