Temperature Effect on Accumulation of Protoporphyrin IX After Topical Application of 5-Aminolevulinic Acid and its Methylester and Hexylester Derivatives in Normal Mouse Skin
Significant amounts of protoporphyrin IX (PpIX) are formed after 6 min of topical application of 5-aminolevulinic acid (ALA) and its hexylester derivative, whereas PpIX is formed after 10 min of topical application of ALA-methylester derivative in normal mouse skin at 37°C. Lowering the skin tempera...
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| Veröffentlicht in: | Photochemistry and photobiology 2002-10, Vol.76 (4), p.452-456 |
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| creator | Juzeniene, Asta Juzenas, Petras Kaalhus, Olav Iani, Vladimir Moan, Johan |
| description | Significant amounts of protoporphyrin IX (PpIX) are formed after 6 min of topical application of 5-aminolevulinic acid (ALA) and its hexylester derivative, whereas PpIX is formed after 10 min of topical application of ALA-methylester derivative in normal mouse skin at 37°C. Lowering the skin temperature to 28–32°C by the administration of the anesthetic Hypnorm–Dormicum reduces the PpIX fluorescence by a factor of 2–3. Practically no PpIX was formed as long as the skin temperature was kept at 12–18°C. At around 30°C PpIX fluorescence appears later after application of ALA-ester derivatives (14–20 min) than after application of ALA (8 min), indicating differences in their bioavailability (delayed penetration through the stratum corneum, cellular uptake, conversion to ALA, PpIX production) in mouse skin in vivo. The difference in lag time in the PpIX formation after application of ALA and ALA-esters may be partly related to deesterification of the ALA-ester molecules. The temperature dependence of PpIX production may be used for improvement of photodynamic therapy with ALA and ALA-ester derivatives, where accumulation of PpIX can be selectively enhanced by increasing the temperature of the target tissue. |
| doi_str_mv | 10.1562/0031-8655(2002)076<0452:TEOAOP>2.0.CO;2 |
| format | Article |
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Lowering the skin temperature to 28–32°C by the administration of the anesthetic Hypnorm–Dormicum reduces the PpIX fluorescence by a factor of 2–3. Practically no PpIX was formed as long as the skin temperature was kept at 12–18°C. At around 30°C PpIX fluorescence appears later after application of ALA-ester derivatives (14–20 min) than after application of ALA (8 min), indicating differences in their bioavailability (delayed penetration through the stratum corneum, cellular uptake, conversion to ALA, PpIX production) in mouse skin in vivo. The difference in lag time in the PpIX formation after application of ALA and ALA-esters may be partly related to deesterification of the ALA-ester molecules. The temperature dependence of PpIX production may be used for improvement of photodynamic therapy with ALA and ALA-ester derivatives, where accumulation of PpIX can be selectively enhanced by increasing the temperature of the target tissue.</description><identifier>ISSN: 0031-8655</identifier><identifier>EISSN: 1751-1097</identifier><identifier>DOI: 10.1562/0031-8655(2002)076<0452:TEOAOP>2.0.CO;2</identifier><identifier>PMID: 12405155</identifier><identifier>CODEN: PHCBAP</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Administration, Topical ; Aminolevulinic Acid - administration & dosage ; Aminolevulinic Acid - chemistry ; Aminolevulinic Acid - pharmacology ; Anesthesia ; Animals ; Esters ; Mice ; PHOTOMEDICINE ; Protoporphyrins - metabolism ; Skin - drug effects ; Skin - metabolism ; Spectrometry, Fluorescence ; Temperature</subject><ispartof>Photochemistry and photobiology, 2002-10, Vol.76 (4), p.452-456</ispartof><rights>American Society for Photobiology</rights><rights>Copyright American Society of Photobiology Oct 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-b426t-560af6cf0cfcbd084f1f9cc410e89dd1a4423bf9cdb6e5d7f676262e8dbee2823</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://bioone.org/doi/pdf/10.1562/0031-8655(2002)076<0452:TEOAOP>2.0.CO;2$$EPDF$$P50$$Gbioone$$H</linktopdf><link.rule.ids>314,780,784,26978,27924,27925,52363</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12405155$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Juzeniene, Asta</creatorcontrib><creatorcontrib>Juzenas, Petras</creatorcontrib><creatorcontrib>Kaalhus, Olav</creatorcontrib><creatorcontrib>Iani, Vladimir</creatorcontrib><creatorcontrib>Moan, Johan</creatorcontrib><title>Temperature Effect on Accumulation of Protoporphyrin IX After Topical Application of 5-Aminolevulinic Acid and its Methylester and Hexylester Derivatives in Normal Mouse Skin</title><title>Photochemistry and photobiology</title><addtitle>Photochem Photobiol</addtitle><description>Significant amounts of protoporphyrin IX (PpIX) are formed after 6 min of topical application of 5-aminolevulinic acid (ALA) and its hexylester derivative, whereas PpIX is formed after 10 min of topical application of ALA-methylester derivative in normal mouse skin at 37°C. Lowering the skin temperature to 28–32°C by the administration of the anesthetic Hypnorm–Dormicum reduces the PpIX fluorescence by a factor of 2–3. Practically no PpIX was formed as long as the skin temperature was kept at 12–18°C. At around 30°C PpIX fluorescence appears later after application of ALA-ester derivatives (14–20 min) than after application of ALA (8 min), indicating differences in their bioavailability (delayed penetration through the stratum corneum, cellular uptake, conversion to ALA, PpIX production) in mouse skin in vivo. The difference in lag time in the PpIX formation after application of ALA and ALA-esters may be partly related to deesterification of the ALA-ester molecules. The temperature dependence of PpIX production may be used for improvement of photodynamic therapy with ALA and ALA-ester derivatives, where accumulation of PpIX can be selectively enhanced by increasing the temperature of the target tissue.</description><subject>Administration, Topical</subject><subject>Aminolevulinic Acid - administration & dosage</subject><subject>Aminolevulinic Acid - chemistry</subject><subject>Aminolevulinic Acid - pharmacology</subject><subject>Anesthesia</subject><subject>Animals</subject><subject>Esters</subject><subject>Mice</subject><subject>PHOTOMEDICINE</subject><subject>Protoporphyrins - metabolism</subject><subject>Skin - drug effects</subject><subject>Skin - metabolism</subject><subject>Spectrometry, Fluorescence</subject><subject>Temperature</subject><issn>0031-8655</issn><issn>1751-1097</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqdkdGK1DAUhoMo7rj6ChK8EL3obJJJ0tYVoYzj7sKuXXAE70KbnrBZ26Ym7eC8lM9oyswqeOlVksOX__zwIXRGyZIKyc4IWdEkk0K8YYSwtySV7wkX7N12Uxbl7Qe2JMt1ec4eoQVNBU0oydPHaPHn1wl6FsI9IZTnKX2KTijjRFAhFujXFroBfDVOHvDGGNAjdj0utJ66qa1GGx_O4FvvRjc4P9ztve3x1TdcmBE83rrB6qrFxTC08fKAi6TobO9a2E2t7a2OebbBVd9gOwZ8A-PdvoUwB8yzS_j58PwI3u5izA4Cjns-O9_F9Bs3BcBfvtv-OXpiqjbAi-N5ir5-2mzXl8l1eXG1Lq6TmjM5JkKSykhtiDa6bkjGDTW51pwSyPKmoRXnbFXHUVNLEE1qZCqZZJA1NQDL2OoUvT7kDt79mGI31dmgoW2rHmIZlTK54nlOIvjqH_DeTb6P3RRjhLKMr_IIXRwg7V0IHowavO0qv1eUqNmvmk2p2ZSa_aroV81-1cGvihO1LtXc6-Vx3VR30PzNOQqNwOYA1Na5Hv570W-ORbxU</recordid><startdate>20021001</startdate><enddate>20021001</enddate><creator>Juzeniene, Asta</creator><creator>Juzenas, Petras</creator><creator>Kaalhus, Olav</creator><creator>Iani, Vladimir</creator><creator>Moan, Johan</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>4T-</scope><scope>7RV</scope><scope>7TM</scope><scope>7U7</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>RC3</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>20021001</creationdate><title>Temperature Effect on Accumulation of Protoporphyrin IX After Topical Application of 5-Aminolevulinic Acid and its Methylester and Hexylester Derivatives in Normal Mouse Skin</title><author>Juzeniene, Asta ; Juzenas, Petras ; Kaalhus, Olav ; Iani, Vladimir ; Moan, Johan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b426t-560af6cf0cfcbd084f1f9cc410e89dd1a4423bf9cdb6e5d7f676262e8dbee2823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Administration, Topical</topic><topic>Aminolevulinic Acid - administration & dosage</topic><topic>Aminolevulinic Acid - chemistry</topic><topic>Aminolevulinic Acid - pharmacology</topic><topic>Anesthesia</topic><topic>Animals</topic><topic>Esters</topic><topic>Mice</topic><topic>PHOTOMEDICINE</topic><topic>Protoporphyrins - metabolism</topic><topic>Skin - drug effects</topic><topic>Skin - metabolism</topic><topic>Spectrometry, Fluorescence</topic><topic>Temperature</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Juzeniene, Asta</creatorcontrib><creatorcontrib>Juzenas, Petras</creatorcontrib><creatorcontrib>Kaalhus, Olav</creatorcontrib><creatorcontrib>Iani, Vladimir</creatorcontrib><creatorcontrib>Moan, Johan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Docstoc</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Nucleic Acids Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Photochemistry and photobiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Juzeniene, Asta</au><au>Juzenas, Petras</au><au>Kaalhus, Olav</au><au>Iani, Vladimir</au><au>Moan, Johan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Temperature Effect on Accumulation of Protoporphyrin IX After Topical Application of 5-Aminolevulinic Acid and its Methylester and Hexylester Derivatives in Normal Mouse Skin</atitle><jtitle>Photochemistry and photobiology</jtitle><addtitle>Photochem Photobiol</addtitle><date>2002-10-01</date><risdate>2002</risdate><volume>76</volume><issue>4</issue><spage>452</spage><epage>456</epage><pages>452-456</pages><issn>0031-8655</issn><eissn>1751-1097</eissn><coden>PHCBAP</coden><abstract>Significant amounts of protoporphyrin IX (PpIX) are formed after 6 min of topical application of 5-aminolevulinic acid (ALA) and its hexylester derivative, whereas PpIX is formed after 10 min of topical application of ALA-methylester derivative in normal mouse skin at 37°C. Lowering the skin temperature to 28–32°C by the administration of the anesthetic Hypnorm–Dormicum reduces the PpIX fluorescence by a factor of 2–3. Practically no PpIX was formed as long as the skin temperature was kept at 12–18°C. At around 30°C PpIX fluorescence appears later after application of ALA-ester derivatives (14–20 min) than after application of ALA (8 min), indicating differences in their bioavailability (delayed penetration through the stratum corneum, cellular uptake, conversion to ALA, PpIX production) in mouse skin in vivo. The difference in lag time in the PpIX formation after application of ALA and ALA-esters may be partly related to deesterification of the ALA-ester molecules. The temperature dependence of PpIX production may be used for improvement of photodynamic therapy with ALA and ALA-ester derivatives, where accumulation of PpIX can be selectively enhanced by increasing the temperature of the target tissue.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>12405155</pmid><doi>10.1562/0031-8655(2002)076<0452:TEOAOP>2.0.CO;2</doi><tpages>5</tpages></addata></record> |
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| subjects | Administration, Topical Aminolevulinic Acid - administration & dosage Aminolevulinic Acid - chemistry Aminolevulinic Acid - pharmacology Anesthesia Animals Esters Mice PHOTOMEDICINE Protoporphyrins - metabolism Skin - drug effects Skin - metabolism Spectrometry, Fluorescence Temperature |
| title | Temperature Effect on Accumulation of Protoporphyrin IX After Topical Application of 5-Aminolevulinic Acid and its Methylester and Hexylester Derivatives in Normal Mouse Skin |
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