Skeletal muscle fiber function and rate of disease progression in amyotrophic lateral sclerosis
The contractile properties of single muscle fibers reflect the functional status of muscle at the cellular level and have not been described in amyotrophic lateral sclerosis (ALS). Chemically skinned single muscle fibers (n = 173), obtained by needle biopsy from six men with ALS, were activated with...
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| Veröffentlicht in: | Muscle & nerve 2002-11, Vol.26 (5), p.636-643 |
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| creator | Krivickas, Lisa S. Yang, Jung-In Kim, Sang-Kyu Frontera, Walter R. |
| description | The contractile properties of single muscle fibers reflect the functional status of muscle at the cellular level and have not been described in amyotrophic lateral sclerosis (ALS). Chemically skinned single muscle fibers (n = 173), obtained by needle biopsy from six men with ALS, were activated with Ca2+, allowing maximal force measurements and specific force (SF) estimates. Maximum unloaded shortening velocity (Vo) was determined using the slack test. The results were compared with muscle from healthy controls. Markers of disease progression included rate of change of ALS functional rating scale score, rate of change of forced vital capacity, and disease duration. Compared with controls, ALS patients had decreased whole muscle SF (measured by a combination of computerized tomography and isokinetic testing) but normal single fiber SF. The Vo was greater for type I fibers in ALS. Patients with slower disease progression had increased single fiber size and a high percentage of hybrid fibers (expressing multiple myosin heavy chain isoforms). A needle biopsy obtained at the time of ALS diagnosis may assist with predicting rate of disease progression. © 2002 Wiley Periodicals, Inc. Muscle Nerve 26: 636–643, 2002 |
| doi_str_mv | 10.1002/mus.10257 |
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Chemically skinned single muscle fibers (n = 173), obtained by needle biopsy from six men with ALS, were activated with Ca2+, allowing maximal force measurements and specific force (SF) estimates. Maximum unloaded shortening velocity (Vo) was determined using the slack test. The results were compared with muscle from healthy controls. Markers of disease progression included rate of change of ALS functional rating scale score, rate of change of forced vital capacity, and disease duration. Compared with controls, ALS patients had decreased whole muscle SF (measured by a combination of computerized tomography and isokinetic testing) but normal single fiber SF. The Vo was greater for type I fibers in ALS. Patients with slower disease progression had increased single fiber size and a high percentage of hybrid fibers (expressing multiple myosin heavy chain isoforms). A needle biopsy obtained at the time of ALS diagnosis may assist with predicting rate of disease progression. © 2002 Wiley Periodicals, Inc. Muscle Nerve 26: 636–643, 2002</description><identifier>ISSN: 0148-639X</identifier><identifier>EISSN: 1097-4598</identifier><identifier>DOI: 10.1002/mus.10257</identifier><identifier>PMID: 12402285</identifier><identifier>CODEN: MUNEDE</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Age Factors ; Aged ; Amyotrophic Lateral Sclerosis - pathology ; Amyotrophic Lateral Sclerosis - physiopathology ; Biological and medical sciences ; Biopsy ; contractile properties ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Disease Progression ; Humans ; Male ; Medical sciences ; Middle Aged ; motor neuron disease ; muscle biopsy ; Muscle Contraction - physiology ; Muscle Fibers, Skeletal - pathology ; Muscle Weakness - pathology ; Muscle Weakness - physiopathology ; Muscle, Skeletal - pathology ; Muscle, Skeletal - physiopathology ; myosin heavy chain ; Neurology ; shortening velocity ; single fiber ; specific force</subject><ispartof>Muscle & nerve, 2002-11, Vol.26 (5), p.636-643</ispartof><rights>Copyright © 2002 Wiley Periodicals, Inc.</rights><rights>2003 INIST-CNRS</rights><rights>Copyright 2002 Wiley Periodicals, Inc. Muscle Nerve 26: 636-643, 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3897-fd732686e166c41ea6ba430b76c8f9158c0f46cfe969848f7d06cd163d71d1db3</citedby><cites>FETCH-LOGICAL-c3897-fd732686e166c41ea6ba430b76c8f9158c0f46cfe969848f7d06cd163d71d1db3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmus.10257$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmus.10257$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27929,27930,45579,45580</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13998372$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12402285$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Krivickas, Lisa S.</creatorcontrib><creatorcontrib>Yang, Jung-In</creatorcontrib><creatorcontrib>Kim, Sang-Kyu</creatorcontrib><creatorcontrib>Frontera, Walter R.</creatorcontrib><title>Skeletal muscle fiber function and rate of disease progression in amyotrophic lateral sclerosis</title><title>Muscle & nerve</title><addtitle>Muscle Nerve</addtitle><description>The contractile properties of single muscle fibers reflect the functional status of muscle at the cellular level and have not been described in amyotrophic lateral sclerosis (ALS). Chemically skinned single muscle fibers (n = 173), obtained by needle biopsy from six men with ALS, were activated with Ca2+, allowing maximal force measurements and specific force (SF) estimates. Maximum unloaded shortening velocity (Vo) was determined using the slack test. The results were compared with muscle from healthy controls. Markers of disease progression included rate of change of ALS functional rating scale score, rate of change of forced vital capacity, and disease duration. Compared with controls, ALS patients had decreased whole muscle SF (measured by a combination of computerized tomography and isokinetic testing) but normal single fiber SF. The Vo was greater for type I fibers in ALS. Patients with slower disease progression had increased single fiber size and a high percentage of hybrid fibers (expressing multiple myosin heavy chain isoforms). A needle biopsy obtained at the time of ALS diagnosis may assist with predicting rate of disease progression. © 2002 Wiley Periodicals, Inc. Muscle Nerve 26: 636–643, 2002</description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Amyotrophic Lateral Sclerosis - pathology</subject><subject>Amyotrophic Lateral Sclerosis - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>contractile properties</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Disease Progression</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>motor neuron disease</subject><subject>muscle biopsy</subject><subject>Muscle Contraction - physiology</subject><subject>Muscle Fibers, Skeletal - pathology</subject><subject>Muscle Weakness - pathology</subject><subject>Muscle Weakness - physiopathology</subject><subject>Muscle, Skeletal - pathology</subject><subject>Muscle, Skeletal - physiopathology</subject><subject>myosin heavy chain</subject><subject>Neurology</subject><subject>shortening velocity</subject><subject>single fiber</subject><subject>specific force</subject><issn>0148-639X</issn><issn>1097-4598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kM1u1DAUhS0EokNhwQsgb0DqItQ_iX-WqIIBaQCJUsrOcuxrMHWSwU5U5u3xMANdsfKV_N3vHh2EnlLykhLCzoel1IF18h5aUaJl03Za3UcrQlvVCK6_nqBHpfwghFAl5EN0QllLGFPdCpnLG0gw24SrxCXAIfaQcVhGN8dpxHb0ONsZ8BSwjwVsAbzN07cMpez_Y0WG3TTnafs9Opwqmqtsr8pTieUxehBsKvDk-J6iqzevP1-8bTYf1-8uXm0ax1UNHLzkTCgBVAjXUrCity0nvRROBU075UhohQughVatCtIT4TwV3Evqqe_5KXpx8NZwPxcosxlicZCSHWFaipFMcKY7UsGzA-hqvpIhmG2Og807Q4nZt2lqEeZPm5V9dpQu_QD-jjzWV4HnR8AWZ1PIdnSx3HFca8Ulq9z5gbuNCXb_v2jeX13-Pd0cNmKZ4de_DZtvjJBcdub6w7pOm_bL-pqbT_w3jW2cFw</recordid><startdate>200211</startdate><enddate>200211</enddate><creator>Krivickas, Lisa S.</creator><creator>Yang, Jung-In</creator><creator>Kim, Sang-Kyu</creator><creator>Frontera, Walter R.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200211</creationdate><title>Skeletal muscle fiber function and rate of disease progression in amyotrophic lateral sclerosis</title><author>Krivickas, Lisa S. ; Yang, Jung-In ; Kim, Sang-Kyu ; Frontera, Walter R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3897-fd732686e166c41ea6ba430b76c8f9158c0f46cfe969848f7d06cd163d71d1db3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Amyotrophic Lateral Sclerosis - pathology</topic><topic>Amyotrophic Lateral Sclerosis - physiopathology</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>contractile properties</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Disease Progression</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>motor neuron disease</topic><topic>muscle biopsy</topic><topic>Muscle Contraction - physiology</topic><topic>Muscle Fibers, Skeletal - pathology</topic><topic>Muscle Weakness - pathology</topic><topic>Muscle Weakness - physiopathology</topic><topic>Muscle, Skeletal - pathology</topic><topic>Muscle, Skeletal - physiopathology</topic><topic>myosin heavy chain</topic><topic>Neurology</topic><topic>shortening velocity</topic><topic>single fiber</topic><topic>specific force</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Krivickas, Lisa S.</creatorcontrib><creatorcontrib>Yang, Jung-In</creatorcontrib><creatorcontrib>Kim, Sang-Kyu</creatorcontrib><creatorcontrib>Frontera, Walter R.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Muscle & nerve</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Krivickas, Lisa S.</au><au>Yang, Jung-In</au><au>Kim, Sang-Kyu</au><au>Frontera, Walter R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Skeletal muscle fiber function and rate of disease progression in amyotrophic lateral sclerosis</atitle><jtitle>Muscle & nerve</jtitle><addtitle>Muscle Nerve</addtitle><date>2002-11</date><risdate>2002</risdate><volume>26</volume><issue>5</issue><spage>636</spage><epage>643</epage><pages>636-643</pages><issn>0148-639X</issn><eissn>1097-4598</eissn><coden>MUNEDE</coden><abstract>The contractile properties of single muscle fibers reflect the functional status of muscle at the cellular level and have not been described in amyotrophic lateral sclerosis (ALS). Chemically skinned single muscle fibers (n = 173), obtained by needle biopsy from six men with ALS, were activated with Ca2+, allowing maximal force measurements and specific force (SF) estimates. Maximum unloaded shortening velocity (Vo) was determined using the slack test. The results were compared with muscle from healthy controls. Markers of disease progression included rate of change of ALS functional rating scale score, rate of change of forced vital capacity, and disease duration. Compared with controls, ALS patients had decreased whole muscle SF (measured by a combination of computerized tomography and isokinetic testing) but normal single fiber SF. The Vo was greater for type I fibers in ALS. Patients with slower disease progression had increased single fiber size and a high percentage of hybrid fibers (expressing multiple myosin heavy chain isoforms). A needle biopsy obtained at the time of ALS diagnosis may assist with predicting rate of disease progression. © 2002 Wiley Periodicals, Inc. Muscle Nerve 26: 636–643, 2002</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>12402285</pmid><doi>10.1002/mus.10257</doi><tpages>8</tpages></addata></record> |
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| subjects | Adult Age Factors Aged Amyotrophic Lateral Sclerosis - pathology Amyotrophic Lateral Sclerosis - physiopathology Biological and medical sciences Biopsy contractile properties Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Disease Progression Humans Male Medical sciences Middle Aged motor neuron disease muscle biopsy Muscle Contraction - physiology Muscle Fibers, Skeletal - pathology Muscle Weakness - pathology Muscle Weakness - physiopathology Muscle, Skeletal - pathology Muscle, Skeletal - physiopathology myosin heavy chain Neurology shortening velocity single fiber specific force |
| title | Skeletal muscle fiber function and rate of disease progression in amyotrophic lateral sclerosis |
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