Alterations in endothelial cell proliferation and apoptosis contribute to vascular remodeling following hind-limb ischemia in rabbits

Hind-limb ischemia is a potent stimulus for angiogenesis. However, capillary density does not change in tibialis anterior muscle (TA) following hind-limb ischemia, despite increases in angiogenic growth factors. The objective of this study was to determine whether changes in proliferation and apopto...

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Veröffentlicht in:	Vascular medicine (London, England) England), 2002-05, Vol.7 (2), p.87-91
Hauptverfasser:	Dai, Qunsheng, Thompson, Michael A, Pippen, Anne M, Cherwek, Hunter, Taylor, Doris A, Annex, Brian H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - physiology Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cell Differentiation - physiology Cell Nucleus - metabolism Cell Nucleus - physiology Disease Models, Animal Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Endothelial Growth Factors - metabolism Endothelium, Vascular - cytology Endothelium, Vascular - physiology Extremities - blood supply Female Immunohistochemistry In Situ Nick-End Labeling Intercellular Signaling Peptides and Proteins - metabolism Ischemia - metabolism Ischemia - physiopathology Lymphokines - metabolism Medical sciences Models, Cardiovascular Muscle, Skeletal - cytology Muscle, Skeletal - metabolism Muscle, Skeletal - physiopathology Myoblasts, Smooth Muscle - cytology Myocytes, Smooth Muscle - cytology Proliferating Cell Nuclear Antigen - metabolism Rabbits Time Factors Umbilical Veins - cytology Umbilical Veins - metabolism Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors
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