Adenosine Receptors as Mediators of Both Cell Proliferation and Cell Death of Cultured Human Melanoma Cells

Adenosine displays contradictory effects on cell growth: it improves cell proliferation, but it may also induce apoptosis and impair cell survival. Following the pharmacologic characterization of adenosine receptor expression on the human melanoma cell line A375, we chose A375 as our cellular model...

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Veröffentlicht in:	Journal of investigative dermatology 2002-10, Vol.119 (4), p.923-933
Hauptverfasser:	Merighi, Stefania, Mirandola, Prisco, Milani, Daniela, Varani, Katia, Gessi, Stefania, Klotz, Karl-Norbert, Leung, Edward, Baraldi, Pier Giovanni, Borea, Pier Andrea
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine - pharmacology adenosine receptors Animals apoptosis Apoptosis - physiology Biological and medical sciences Cell death Cell Division cell proliferation CHO Cells Cricetinae Cyclic AMP-Dependent Protein Kinases - physiology Dermatology Enzyme Activation Humans Medical sciences melanoma Melanoma - pathology Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 Mitogen-Activated Protein Kinases - metabolism molecular signaling Protein Kinase C - physiology Receptor, Adenosine A2A Receptor, Adenosine A3 Receptors, Purinergic P1 - physiology Tumor Cells, Cultured Tumors of the skin and soft tissue. Premalignant lesions
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