Decreased blood glucose excursion by nateglinide ameliorated neuropathic changes in Goto-Kakizaki rats, an animal model of non-obese type 2 diabetes

In the present study, we examined the effect of long-term suppression of postprandial hyperglycemia and glycemic fluctuation in Goto-Kakizaki (GK) rats, a type 2 diabetic animal model, by nateglinide (NG), a fast-acting hypoglycemic agent, on some measures of neuropathy and compared the outcome with...

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Veröffentlicht in:	Metabolism, clinical and experimental clinical and experimental, 2002-11, Vol.51 (11), p.1452-1457
Hauptverfasser:	Kitahara, Yoshiro, Miura, Kyoko, Takesue, Kaori, Mine, Tomoyuki, Wada, Ryuichi, Uchida, Yoshiaki, Ito, Satoru, Yagihashi, Soroku
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Area Under Curve Associated diseases and complications Biological and medical sciences Blood Glucose - drug effects Blood Glucose - metabolism Cyclohexanes - pharmacology Diabetes Mellitus, Experimental - blood Diabetes Mellitus, Experimental - physiopathology Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - physiopathology Diabetes. Impaired glucose tolerance Diabetic Neuropathies - blood Diabetic Neuropathies - etiology Diabetic Neuropathies - physiopathology Diabetic Neuropathies - prevention & control Endocrine pancreas. Apud cells (diseases) Endocrinopathies General and cellular metabolism. Vitamins Glyburide - pharmacology Glycated Hemoglobin A - metabolism Hypoglycemic Agents - pharmacology Insulin - blood Medical sciences Nateglinide Pharmacology. Drug treatments Phenylalanine - analogs & derivatives Phenylalanine - pharmacology Postprandial Period Rats Rats, Inbred Strains Rats, Wistar Sciatic Nerve - metabolism Time Factors
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