Regulation of lymphoid homeostasis by interleukin-15

Interleukin (IL)-15 is a member of the common gamma chain family of cytokines, and is closely related to IL-2. While these two cytokines share several important biological functions in vitro, recent mouse models have demonstrated unique roles for these two cytokines in supporting lymphoid homeostasi...

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Veröffentlicht in:	Cytokine & growth factor reviews 2002-12, Vol.13 (6), p.429-439
Hauptverfasser:	Lodolce, James P., Burkett, Patrick R, Koka, Rima M, Boone, David L, Ma, Averil
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bystander proliferation Cell Division Humans IL-15 IL-15Rα Immunologic Memory Immunological memory Interleukin-15 - metabolism Interleukin-15 - physiology Lymphocytes - metabolism Lymphoid homeostasis Models, Biological Receptors, Interleukin-15 Receptors, Interleukin-2 - metabolism Signal Transduction
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Beschreibung
Zusammenfassung:	Interleukin (IL)-15 is a member of the common gamma chain family of cytokines, and is closely related to IL-2. While these two cytokines share several important biological functions in vitro, recent mouse models have demonstrated unique roles for these two cytokines in supporting lymphoid homeostasis in vivo. IL-15 has been shown to regulate the homeostasis of both innate and adaptive immune cells, and this review will discuss several ways in which this pleiotropic cytokine may support lymphoid homeostasis.
ISSN:	1359-6101
DOI:	10.1016/S1359-6101(02)00029-1