STUDIES ON CEPHALOSPORIN ANTIBIOTICS: IV. SYNTHESIS, ANTIBACTERIAL ACTIVITY AND ORAL ABSORPTION OF NEW 3-(2-SUBSTITUTED-VINYLTHIO)-7β-[(Z)-2-(2-AMINOTHIAZOL-4-YL)-2-(CARBOXYMETHOXYIMINO)ACETAMIDO]CEPHALOSPORINS

A series of new 7β-[(Z)-2-(2-aminothiazol-4-yl)-2-(carboxymethoxyimino)acetamido]cephalosporins (1) having various substituted-vinylthio groups at the C-3 position of the cephem nucleus was synthesized and evaluated for antibacterial activity and oral absorption in rats in comparison with cefixime....

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Veröffentlicht in:	Journal of antibiotics 1991/12/25, Vol.44(12), pp.1422-1431
Hauptverfasser:	YOKOO, CHIHIRO, GOI, MASAMI, ONODERA, AKIRA, FUKUSHIMA, HIROSHI, NAGATE, TAKATOSHI
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Cephalosporins - chemical synthesis Cephalosporins - pharmacokinetics Cephalosporins - pharmacology Intestinal Absorption Male Microbial Sensitivity Tests Rats Rats, Inbred Strains Structure-Activity Relationship
Online-Zugang:	Volltext
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