Which Came First, the Lectin/Classical Pathway or the Alternative Pathway of Complement?

It is a widely accepted canon of immunology that the alternative pathway is more primitive and hence older in evolutionary terms than the lectin/classical pathway. This idea has been reinforced by the discovery of “C3” and “factor B” proteins in invertebrate species. However, it is clear that the ge...

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Veröffentlicht in:	Immunobiology (1979) 2002-09, Vol.205 (4), p.340-354
1. Verfasser:	Dodds, Alister W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Complement Pathway, Alternative - genetics Complement Pathway, Classical - genetics Humans Immunity, Innate - genetics Lectins - immunology Phylogeny
Online-Zugang:	Volltext
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