Cyclic GMP-dependent inhibition of acid sphingomyelinase by nitric oxide: an early step in protection against apoptosis

Activation of acid and neutral sphingomyelinases, and the ensuing generation of ceramide, contributes to the biological effects of tumour necrosis factor-alpha (TNF-alpha), one of which is apoptosis. While the mechanisms of activation of sphingomyelinases by the cytokine are being unravelled, less i...

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Veröffentlicht in:	Cell death and differentiation 2002-11, Vol.9 (11), p.1248-1255
Hauptverfasser:	Barsacchi, R, Perrotta, C, Sestili, P, Cantoni, O, Moncada, S, Clementi, E
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Apoptosis Apoptosis - drug effects Apoptosis - physiology Cell death Cyclic GMP - metabolism Cycloheximide - pharmacology Cytokines Enzymes Humans Kinases Nitric oxide Nitric Oxide - metabolism Protein Synthesis Inhibitors - pharmacology Proteins Sphingomyelin Phosphodiesterase - antagonists & inhibitors Sphingomyelin Phosphodiesterase - metabolism Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-TNF
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