Recovery of known T-cell epitopes by computational scanning of a viral genome

A new computational method (EpiDock) is proposed for predicting peptide binding to class I MHC proteins, from the amino acid sequence of any protein of immunological interest. Starting from the primary structure of the target protein, individual three-dimensional structures of all possible MHC-pepti...

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of computer-aided molecular design 2002-04, Vol.16 (4), p.229-243
Hauptverfasser:	Logean, Antoine, Rognan, Didier
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Amino Acid Motifs Amino Acid Sequence Amino acids Binders Databases, Genetic Epitope Mapping - statistics & numerical data Genome, Viral Hepatitis B Antigens - genetics Hepatitis B virus - genetics Hepatitis B virus - immunology HLA-A Antigens - genetics HLA-A Antigens - metabolism HLA-A2 Antigen HLA-B Antigens - genetics HLA-B Antigens - metabolism HLA-B27 Antigen Humans Immunodominant Epitopes - genetics In Vitro Techniques Peptides Protein Binding Proteins Software T-Lymphocytes - immunology Thermodynamics
Online-Zugang:	Volltext
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