Carrier-mediated outward transport of dopamine from adrenergic varicosities of the vas deferens of reserpine-pretreated rats
In vasa deferentia of reserpine-pretreated rats a carrier-mediated (i.e., desipramine-sensitive) outward transport of endogenous dopamine was induced by either tyramine or ouabain. The dopamine taking part in the efflux induced by tyramine (and the concomitant efflux of DOPAC) was derived from ongoi...
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| Veröffentlicht in: | Naunyn-Schmiedeberg's archives of pharmacology 1991-12, Vol.344 (6), p.619-622 |
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| container_title | Naunyn-Schmiedeberg's archives of pharmacology |
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| creator | LANGELOH, A HALBRÜGGE, T TRENDELENBURG, U |
| description | In vasa deferentia of reserpine-pretreated rats a carrier-mediated (i.e., desipramine-sensitive) outward transport of endogenous dopamine was induced by either tyramine or ouabain. The dopamine taking part in the efflux induced by tyramine (and the concomitant efflux of DOPAC) was derived from ongoing synthesis of dopamine. Inhibition of MAO trebled the rate of spontaneous efflux of dopamine and reduced the spontaneous efflux of DOPAC by 90%. After inhibition of MAO, desipramine caused a further five-fold increase in the basal efflux of dopamine with no change in the basal efflux of DOPAC. Inhibition of COMT failed to affect the spontaneous efflux of dopamine but increased that of DOPAC. It is concluded that, after depletion of the noradrenaline stores by pretreatment with reserpine, an outward transport of axoplasmic dopamine is induced by the same mechanisms that (without any pretreatment with reserpine) are known to initiate an outward transport of noradrenaline. |
| doi_str_mv | 10.1007/BF00174744 |
| format | Article |
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The dopamine taking part in the efflux induced by tyramine (and the concomitant efflux of DOPAC) was derived from ongoing synthesis of dopamine. Inhibition of MAO trebled the rate of spontaneous efflux of dopamine and reduced the spontaneous efflux of DOPAC by 90%. After inhibition of MAO, desipramine caused a further five-fold increase in the basal efflux of dopamine with no change in the basal efflux of DOPAC. Inhibition of COMT failed to affect the spontaneous efflux of dopamine but increased that of DOPAC. It is concluded that, after depletion of the noradrenaline stores by pretreatment with reserpine, an outward transport of axoplasmic dopamine is induced by the same mechanisms that (without any pretreatment with reserpine) are known to initiate an outward transport of noradrenaline.</description><identifier>ISSN: 0028-1298</identifier><identifier>EISSN: 1432-1912</identifier><identifier>DOI: 10.1007/BF00174744</identifier><identifier>PMID: 1775194</identifier><identifier>CODEN: NSAPCC</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>3,4-Dihydroxyphenylacetic Acid - metabolism ; Animals ; Biological and medical sciences ; Biological Transport, Active - drug effects ; Dopamine - metabolism ; Fundamental and applied biological sciences. Psychology ; Male ; Ouabain - pharmacology ; Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ ; Rats ; Rats, Inbred Strains ; Reserpine - pharmacology ; Tyramine - pharmacology ; Vas Deferens - drug effects ; Vas Deferens - metabolism ; Vertebrates: nervous system and sense organs</subject><ispartof>Naunyn-Schmiedeberg's archives of pharmacology, 1991-12, Vol.344 (6), p.619-622</ispartof><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c342t-b786e423f5239a5f74f17f99a5069582422714c03f04d83a39a51ae225cb352b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5178970$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1775194$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LANGELOH, A</creatorcontrib><creatorcontrib>HALBRÜGGE, T</creatorcontrib><creatorcontrib>TRENDELENBURG, U</creatorcontrib><title>Carrier-mediated outward transport of dopamine from adrenergic varicosities of the vas deferens of reserpine-pretreated rats</title><title>Naunyn-Schmiedeberg's archives of pharmacology</title><addtitle>Naunyn Schmiedebergs Arch Pharmacol</addtitle><description>In vasa deferentia of reserpine-pretreated rats a carrier-mediated (i.e., desipramine-sensitive) outward transport of endogenous dopamine was induced by either tyramine or ouabain. The dopamine taking part in the efflux induced by tyramine (and the concomitant efflux of DOPAC) was derived from ongoing synthesis of dopamine. Inhibition of MAO trebled the rate of spontaneous efflux of dopamine and reduced the spontaneous efflux of DOPAC by 90%. After inhibition of MAO, desipramine caused a further five-fold increase in the basal efflux of dopamine with no change in the basal efflux of DOPAC. Inhibition of COMT failed to affect the spontaneous efflux of dopamine but increased that of DOPAC. It is concluded that, after depletion of the noradrenaline stores by pretreatment with reserpine, an outward transport of axoplasmic dopamine is induced by the same mechanisms that (without any pretreatment with reserpine) are known to initiate an outward transport of noradrenaline.</description><subject>3,4-Dihydroxyphenylacetic Acid - metabolism</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Biological Transport, Active - drug effects</subject><subject>Dopamine - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Male</subject><subject>Ouabain - pharmacology</subject><subject>Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Reserpine - pharmacology</subject><subject>Tyramine - pharmacology</subject><subject>Vas Deferens - drug effects</subject><subject>Vas Deferens - metabolism</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0028-1298</issn><issn>1432-1912</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0T1rHDEQBmBhEuyL7Sa9YYuQIrCxRh8rbZkcsRMwuLHrRacd2Qq3p81IlxDIj7fOd9hlKomZRyOYl7H3wD8D5-by6xXnYJRR6ogtQEnRQg_iDVtwLmwLorcn7F3OPznnHWh9zI7BGA29WrB_S0cUkdoJx-gKjk3alj-OxqaQ2-Q5UWlSaMY0uylusAmUpsaNhBukh-ib346iTzmWiHkHyyPWWm5GDFjRc40wI831dTsTFsLnb8iVfMbeBrfOeH44T9n91be75ff25vb6x_LLTeulEqVdGduhEjJoIXung1EBTOjrlXe9tkIJYUB5LgNXo5Vuh8ChENqvpBYreco-7ufOlH5tMZdhitnjeu02mLZ5MKITwLX6L4ROcGOtrfDTHnpKOROGYaY4Ofo7AB92mQyvmVR8cZi6XdU1v9J9CLX_4dB32bt1qIv3Mb8wDcb2hssnf_OUBA</recordid><startdate>19911201</startdate><enddate>19911201</enddate><creator>LANGELOH, A</creator><creator>HALBRÜGGE, T</creator><creator>TRENDELENBURG, U</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19911201</creationdate><title>Carrier-mediated outward transport of dopamine from adrenergic varicosities of the vas deferens of reserpine-pretreated rats</title><author>LANGELOH, A ; HALBRÜGGE, T ; TRENDELENBURG, U</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c342t-b786e423f5239a5f74f17f99a5069582422714c03f04d83a39a51ae225cb352b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>3,4-Dihydroxyphenylacetic Acid - metabolism</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Biological Transport, Active - drug effects</topic><topic>Dopamine - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Male</topic><topic>Ouabain - pharmacology</topic><topic>Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Reserpine - pharmacology</topic><topic>Tyramine - pharmacology</topic><topic>Vas Deferens - drug effects</topic><topic>Vas Deferens - metabolism</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LANGELOH, A</creatorcontrib><creatorcontrib>HALBRÜGGE, T</creatorcontrib><creatorcontrib>TRENDELENBURG, U</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Naunyn-Schmiedeberg's archives of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LANGELOH, A</au><au>HALBRÜGGE, T</au><au>TRENDELENBURG, U</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Carrier-mediated outward transport of dopamine from adrenergic varicosities of the vas deferens of reserpine-pretreated rats</atitle><jtitle>Naunyn-Schmiedeberg's archives of pharmacology</jtitle><addtitle>Naunyn Schmiedebergs Arch Pharmacol</addtitle><date>1991-12-01</date><risdate>1991</risdate><volume>344</volume><issue>6</issue><spage>619</spage><epage>622</epage><pages>619-622</pages><issn>0028-1298</issn><eissn>1432-1912</eissn><coden>NSAPCC</coden><abstract>In vasa deferentia of reserpine-pretreated rats a carrier-mediated (i.e., desipramine-sensitive) outward transport of endogenous dopamine was induced by either tyramine or ouabain. The dopamine taking part in the efflux induced by tyramine (and the concomitant efflux of DOPAC) was derived from ongoing synthesis of dopamine. Inhibition of MAO trebled the rate of spontaneous efflux of dopamine and reduced the spontaneous efflux of DOPAC by 90%. After inhibition of MAO, desipramine caused a further five-fold increase in the basal efflux of dopamine with no change in the basal efflux of DOPAC. Inhibition of COMT failed to affect the spontaneous efflux of dopamine but increased that of DOPAC. It is concluded that, after depletion of the noradrenaline stores by pretreatment with reserpine, an outward transport of axoplasmic dopamine is induced by the same mechanisms that (without any pretreatment with reserpine) are known to initiate an outward transport of noradrenaline.</abstract><cop>Heidelberg</cop><cop>Berlin</cop><cop>New York, NY</cop><pub>Springer</pub><pmid>1775194</pmid><doi>10.1007/BF00174744</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0028-1298 |
| ispartof | Naunyn-Schmiedeberg's archives of pharmacology, 1991-12, Vol.344 (6), p.619-622 |
| issn | 0028-1298 1432-1912 |
| language | eng |
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| subjects | 3,4-Dihydroxyphenylacetic Acid - metabolism Animals Biological and medical sciences Biological Transport, Active - drug effects Dopamine - metabolism Fundamental and applied biological sciences. Psychology Male Ouabain - pharmacology Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ Rats Rats, Inbred Strains Reserpine - pharmacology Tyramine - pharmacology Vas Deferens - drug effects Vas Deferens - metabolism Vertebrates: nervous system and sense organs |
| title | Carrier-mediated outward transport of dopamine from adrenergic varicosities of the vas deferens of reserpine-pretreated rats |
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