New Tacrine−Huperzine A Hybrids (Huprines): Highly Potent Tight-Binding Acetylcholinesterase Inhibitors of Interest for the Treatment of Alzheimer's Disease

Several new 12-amino-6,7,10,11-tetrahydro-7,11-methanocycloocta[b]quinoline derivatives (tacrine−huperzine A hybrids, huprines) have been synthesized and tested as acetylcholinesterase (AChE) inhibitors. All of the new compounds contain either a methyl or ethyl group at position 9 and one or two (ch...

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Veröffentlicht in:	Journal of medicinal chemistry 2000-11, Vol.43 (24), p.4657-4666
Hauptverfasser:	Camps, Pelayo, El Achab, Rachid, Morral, Jordi, Muñoz-Torrero, Diego, Badia, Albert, Baños, Josep Eladi, Vivas, Nuria María, Barril, Xavier, Orozco, Modesto, Luque, Francisco Javier
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholinesterase - metabolism Alkaloids Alzheimer Disease - drug therapy Animals Biological and medical sciences Bridged Bicyclo Compounds - chemical synthesis Bridged Bicyclo Compounds - chemistry Bridged Bicyclo Compounds - pharmacology Butyrylcholinesterase - metabolism Cattle Cholinesterase Inhibitors - chemical synthesis Cholinesterase Inhibitors - chemistry Cholinesterase Inhibitors - pharmacology Humans In Vitro Techniques Male Medical sciences Mice Models, Molecular Neuromuscular Junction - drug effects Neuromuscular Junction - physiology Neuromuscular Nondepolarizing Agents - pharmacology Neuropharmacology Neuroprotective Agents - chemical synthesis Neuroprotective Agents - chemistry Neuroprotective Agents - pharmacology Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Quinolines - chemical synthesis Quinolines - chemistry Quinolines - pharmacology Rats Rats, Sprague-Dawley Sesquiterpenes - chemistry Stereoisomerism Structure-Activity Relationship Tacrine - chemistry Tubocurarine - pharmacology
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