Histone genes are located at the sphere loci of Xenopus lampbrush chromosomes
In the anuran Xenopus, as has been demonstrated previously in several species of urodele Amphibia, histone genes lie at the sphere organizer loci of the lampbrush chromosomes. They were located by in situ hybridization of a 3H-labelled histone H4 anti-sense cRNA probe applied to lampbrush preparatio...
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| Veröffentlicht in: | Chromosoma 1991-12, Vol.101 (4), p.245-251 |
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| creator | CALLAN, H. G GALL, J. G MURPHY, C |
| description | In the anuran Xenopus, as has been demonstrated previously in several species of urodele Amphibia, histone genes lie at the sphere organizer loci of the lampbrush chromosomes. They were located by in situ hybridization of a 3H-labelled histone H4 anti-sense cRNA probe applied to lampbrush preparations in which transcript RNA had been retained, and likewise to preparations in which transcripts were absent but whose DNA had been denatured prior to hybridization. In Xenopus the histone genes lie in intimate association with the spheres that are attached to the lampbrush chromosomes, but they are absent from spheres that lie free in the germinal vesicle. The Anura separated from the Urodela several hundred million years ago, so the sphere organizer/histone gene association is of great antiquity. This suggests that the association has a functional significance, though it is one that has yet to be discovered. |
| doi_str_mv | 10.1007/BF00365156 |
| format | Article |
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The Anura separated from the Urodela several hundred million years ago, so the sphere organizer/histone gene association is of great antiquity. This suggests that the association has a functional significance, though it is one that has yet to be discovered.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Chromosome Mapping</subject><subject>Cytogenetics</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetics of eukaryotes. 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Biological and molecular evolution</topic><topic>Histones - genetics</topic><topic>Multigene Family</topic><topic>Vertebrata</topic><topic>Xenopus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CALLAN, H. G</creatorcontrib><creatorcontrib>GALL, J. G</creatorcontrib><creatorcontrib>MURPHY, C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Chromosoma</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CALLAN, H. G</au><au>GALL, J. 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| ispartof | Chromosoma, 1991-12, Vol.101 (4), p.245-251 |
| issn | 0009-5915 1432-0886 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Animals Biological and medical sciences Chromosome Mapping Cytogenetics Female Fundamental and applied biological sciences. Psychology Genetics of eukaryotes. Biological and molecular evolution Histones - genetics Multigene Family Vertebrata Xenopus |
| title | Histone genes are located at the sphere loci of Xenopus lampbrush chromosomes |
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