Inhibitory smads and TGF-β signaling in glomerular cells

Smad6 and Smad7 are inhibitory SMADs with putative functional roles at the intersection of major intracellular signaling networks, including TGF-beta, receptor tyrosine kinase (RTK), JAK/STAT, and NF-kappaB pathways. This study reports differential functional roles and regulation of Smad6 and Smad7...

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Veröffentlicht in:	Journal of the American Society of Nephrology 2002-11, Vol.13 (11), p.2657-2666
Hauptverfasser:	SCHIFFER, Mario, SCHIFFER, Lena E, GUPTA, Arti, SHAW, Andrey S, ROBERTS, Ian S. D, MUNDEL, Peter, BÖTTINGER, Erwin P
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Animals Biological and medical sciences Cells, Cultured Cytoskeletal Proteins Diabetic Nephropathies - metabolism DNA-Binding Proteins - metabolism Glomerular Mesangium - metabolism Glomerulonephritis Glomerulosclerosis, Focal Segmental - metabolism Humans Kidney Diseases - metabolism Kidney Glomerulus - pathology Kidney Glomerulus - physiopathology Lupus Nephritis - metabolism Medical sciences Mice Mice, Inbred C57BL Mice, Inbred NZB Mice, Knockout - genetics Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Nephrosis, Lipoid - metabolism Proteins - genetics Reference Values Signal Transduction - physiology Smad2 Protein Smad3 Protein Smad6 Protein Smad7 Protein Trans-Activators - metabolism Transforming Growth Factor beta - metabolism
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