Herpes vector-mediated expression of proenkephalin reduces bone cancer pain

We examined whether a herpes simplex virus vector that expresses human proenkephalin could be used to attenuate nociception in a model of bone cancer pain in mice. Osteolytic sarcoma cells were implanted into the medullary space of the right femur, followed by a subcutaneous inoculation of a replica...

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Veröffentlicht in:	Annals of neurology 2002-11, Vol.52 (5), p.662-665
Hauptverfasser:	Goss, James R., Harley, Cara F., Mata, Marina, O'Malley, Mark E., Goins, William F., Hu, Xiaoping, Glorioso, Joseph C., Fink, David J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Bone Neoplasms - therapy Diseases of the osteoarticular system Enkephalins - genetics Genetic Therapy Genetic Vectors Humans Male Medical sciences Mice Mice, Inbred C3H Osteosarcoma - therapy Palliative Care - methods Protein Precursors - genetics Sarcoma, Experimental - therapy Simplexvirus - genetics Tumors of striated muscle and skeleton
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