Herpes vector-mediated expression of proenkephalin reduces bone cancer pain
We examined whether a herpes simplex virus vector that expresses human proenkephalin could be used to attenuate nociception in a model of bone cancer pain in mice. Osteolytic sarcoma cells were implanted into the medullary space of the right femur, followed by a subcutaneous inoculation of a replica...
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| Veröffentlicht in: | Annals of neurology 2002-11, Vol.52 (5), p.662-665 |
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| container_end_page | 665 |
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| container_issue | 5 |
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| container_title | Annals of neurology |
| container_volume | 52 |
| creator | Goss, James R. Harley, Cara F. Mata, Marina O'Malley, Mark E. Goins, William F. Hu, Xiaoping Glorioso, Joseph C. Fink, David J. |
| description | We examined whether a herpes simplex virus vector that expresses human proenkephalin could be used to attenuate nociception in a model of bone cancer pain in mice. Osteolytic sarcoma cells were implanted into the medullary space of the right femur, followed by a subcutaneous inoculation of a replication‐defective herpes simplex virus vector expressing human proenkephalin (vector SHPE) or a lacZ‐expressing control vector (vector SHZ). SHPE‐inoculated mice demonstrated a significant, naltrexone‐reversible decrease in pain‐related behavior assessed during open‐field motor activity. These results suggest that gene transfer with an enkephalin‐expressing vector may be used to treat pain resulting from cancer in bone. |
| doi_str_mv | 10.1002/ana.10343 |
| format | Article |
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Osteolytic sarcoma cells were implanted into the medullary space of the right femur, followed by a subcutaneous inoculation of a replication‐defective herpes simplex virus vector expressing human proenkephalin (vector SHPE) or a lacZ‐expressing control vector (vector SHZ). SHPE‐inoculated mice demonstrated a significant, naltrexone‐reversible decrease in pain‐related behavior assessed during open‐field motor activity. These results suggest that gene transfer with an enkephalin‐expressing vector may be used to treat pain resulting from cancer in bone.</description><identifier>ISSN: 0364-5134</identifier><identifier>EISSN: 1531-8249</identifier><identifier>DOI: 10.1002/ana.10343</identifier><identifier>PMID: 12402268</identifier><identifier>CODEN: ANNED3</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Animals ; Biological and medical sciences ; Bone Neoplasms - therapy ; Diseases of the osteoarticular system ; Enkephalins - genetics ; Genetic Therapy ; Genetic Vectors ; Humans ; Male ; Medical sciences ; Mice ; Mice, Inbred C3H ; Osteosarcoma - therapy ; Palliative Care - methods ; Protein Precursors - genetics ; Sarcoma, Experimental - therapy ; Simplexvirus - genetics ; Tumors of striated muscle and skeleton</subject><ispartof>Annals of neurology, 2002-11, Vol.52 (5), p.662-665</ispartof><rights>Copyright © 2002 Wiley‐Liss, Inc.</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4553-8ba76bfd4ff8f7e4d2f1bbccb9fb763a762005daf311c2f31af3e8dcffb4921b3</citedby><cites>FETCH-LOGICAL-c4553-8ba76bfd4ff8f7e4d2f1bbccb9fb763a762005daf311c2f31af3e8dcffb4921b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fana.10343$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fana.10343$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27922,27923,45572,45573</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14004645$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12402268$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Goss, James R.</creatorcontrib><creatorcontrib>Harley, Cara F.</creatorcontrib><creatorcontrib>Mata, Marina</creatorcontrib><creatorcontrib>O'Malley, Mark E.</creatorcontrib><creatorcontrib>Goins, William F.</creatorcontrib><creatorcontrib>Hu, Xiaoping</creatorcontrib><creatorcontrib>Glorioso, Joseph C.</creatorcontrib><creatorcontrib>Fink, David J.</creatorcontrib><title>Herpes vector-mediated expression of proenkephalin reduces bone cancer pain</title><title>Annals of neurology</title><addtitle>Ann Neurol</addtitle><description>We examined whether a herpes simplex virus vector that expresses human proenkephalin could be used to attenuate nociception in a model of bone cancer pain in mice. Osteolytic sarcoma cells were implanted into the medullary space of the right femur, followed by a subcutaneous inoculation of a replication‐defective herpes simplex virus vector expressing human proenkephalin (vector SHPE) or a lacZ‐expressing control vector (vector SHZ). SHPE‐inoculated mice demonstrated a significant, naltrexone‐reversible decrease in pain‐related behavior assessed during open‐field motor activity. These results suggest that gene transfer with an enkephalin‐expressing vector may be used to treat pain resulting from cancer in bone.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Bone Neoplasms - therapy</subject><subject>Diseases of the osteoarticular system</subject><subject>Enkephalins - genetics</subject><subject>Genetic Therapy</subject><subject>Genetic Vectors</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred C3H</subject><subject>Osteosarcoma - therapy</subject><subject>Palliative Care - methods</subject><subject>Protein Precursors - genetics</subject><subject>Sarcoma, Experimental - therapy</subject><subject>Simplexvirus - genetics</subject><subject>Tumors of striated muscle and skeleton</subject><issn>0364-5134</issn><issn>1531-8249</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1PAjEQhhujEUQP_gGzF008rPRrPzgSomAgeBCjt6btTmNl2V1bUPj3VkE5eWkn6fPOTB-Ezgm-IRjTrqxkKBhnB6hNEkbinPLeIWpjlvI4IYy30In3bxjjXkrwMWoRyjGlad5G4xG4Bnz0AXpZu3gBhZVLKCJYNw68t3UV1SZqXA3VHJpXWdoqclCsdMiouoJIy0qDixppq1N0ZGTp4Wx3d9DT3e1sMIonD8P7QX8Sa54kLM6VzFJlCm5MbjLgBTVEKa1Vz6gsZeGRYpwU0jBCNA1nqCAvtDGK9yhRrIOutn3DWu8r8EuxsF5DWcoK6pUXGU1Jkmc4gNdbULvaewdGNM4upNsIgsW3ORHMiR9zgb3YNV2pYGFP7lQF4HIHSK9laVz4uPV7jmPMU54ErrvlPm0Jm_8niv60_zs63iasX8L6LyHdXKQZyxLxPB2KWZ5NXh4HuRizLx9blRY</recordid><startdate>200211</startdate><enddate>200211</enddate><creator>Goss, James R.</creator><creator>Harley, Cara F.</creator><creator>Mata, Marina</creator><creator>O'Malley, Mark E.</creator><creator>Goins, William F.</creator><creator>Hu, Xiaoping</creator><creator>Glorioso, Joseph C.</creator><creator>Fink, David J.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Willey-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200211</creationdate><title>Herpes vector-mediated expression of proenkephalin reduces bone cancer pain</title><author>Goss, James R. ; Harley, Cara F. ; Mata, Marina ; O'Malley, Mark E. ; Goins, William F. ; Hu, Xiaoping ; Glorioso, Joseph C. ; Fink, David J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4553-8ba76bfd4ff8f7e4d2f1bbccb9fb763a762005daf311c2f31af3e8dcffb4921b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Bone Neoplasms - therapy</topic><topic>Diseases of the osteoarticular system</topic><topic>Enkephalins - genetics</topic><topic>Genetic Therapy</topic><topic>Genetic Vectors</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred C3H</topic><topic>Osteosarcoma - therapy</topic><topic>Palliative Care - methods</topic><topic>Protein Precursors - genetics</topic><topic>Sarcoma, Experimental - therapy</topic><topic>Simplexvirus - genetics</topic><topic>Tumors of striated muscle and skeleton</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Goss, James R.</creatorcontrib><creatorcontrib>Harley, Cara F.</creatorcontrib><creatorcontrib>Mata, Marina</creatorcontrib><creatorcontrib>O'Malley, Mark E.</creatorcontrib><creatorcontrib>Goins, William F.</creatorcontrib><creatorcontrib>Hu, Xiaoping</creatorcontrib><creatorcontrib>Glorioso, Joseph C.</creatorcontrib><creatorcontrib>Fink, David J.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Goss, James R.</au><au>Harley, Cara F.</au><au>Mata, Marina</au><au>O'Malley, Mark E.</au><au>Goins, William F.</au><au>Hu, Xiaoping</au><au>Glorioso, Joseph C.</au><au>Fink, David J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Herpes vector-mediated expression of proenkephalin reduces bone cancer pain</atitle><jtitle>Annals of neurology</jtitle><addtitle>Ann Neurol</addtitle><date>2002-11</date><risdate>2002</risdate><volume>52</volume><issue>5</issue><spage>662</spage><epage>665</epage><pages>662-665</pages><issn>0364-5134</issn><eissn>1531-8249</eissn><coden>ANNED3</coden><abstract>We examined whether a herpes simplex virus vector that expresses human proenkephalin could be used to attenuate nociception in a model of bone cancer pain in mice. Osteolytic sarcoma cells were implanted into the medullary space of the right femur, followed by a subcutaneous inoculation of a replication‐defective herpes simplex virus vector expressing human proenkephalin (vector SHPE) or a lacZ‐expressing control vector (vector SHZ). SHPE‐inoculated mice demonstrated a significant, naltrexone‐reversible decrease in pain‐related behavior assessed during open‐field motor activity. These results suggest that gene transfer with an enkephalin‐expressing vector may be used to treat pain resulting from cancer in bone.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>12402268</pmid><doi>10.1002/ana.10343</doi><tpages>4</tpages></addata></record> |
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| subjects | Animals Biological and medical sciences Bone Neoplasms - therapy Diseases of the osteoarticular system Enkephalins - genetics Genetic Therapy Genetic Vectors Humans Male Medical sciences Mice Mice, Inbred C3H Osteosarcoma - therapy Palliative Care - methods Protein Precursors - genetics Sarcoma, Experimental - therapy Simplexvirus - genetics Tumors of striated muscle and skeleton |
| title | Herpes vector-mediated expression of proenkephalin reduces bone cancer pain |
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