Exogenous nitric oxide downregulates MIP-2 and MIP-1alpha chemokines and MAPK p44/42 after ischemia and reperfusion of the rat kidney

The mechanisms by which nitric oxide (NO) exerts its protective effect in the ischemia/reperfusion (I/R) injury of the kidney have not been fully determined. The hypothesis of this study was based on the assumption that I/R upregulates some chemokines (MIP-2 and MIP-1alpha) as well as certain protei...

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Veröffentlicht in:	Journal of investigative surgery 2002-09, Vol.15 (5), p.287-296
Hauptverfasser:	Martinez-Mier, Gustavo, Toledo-Pereyra, Luis H, McDuffie, J Eric, Warner, Roscoe L, Hsiao, Chin, Stapleton, Susan R, Ward, Peter A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chemokine CCL3 Chemokine CCL4 Chemokine CXCL2 Chemokines, CXC Down-Regulation - drug effects Down-Regulation - physiology Intercellular Signaling Peptides and Proteins Kidney - immunology Kidney - metabolism Macrophage Inflammatory Proteins - metabolism Male MAP Kinase Signaling System - drug effects MAP Kinase Signaling System - immunology Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 Mitogen-Activated Protein Kinases - metabolism Monokines - metabolism Nitric Oxide - metabolism Nitric Oxide Donors - pharmacology Nitroprusside - pharmacology Rats Rats, Sprague-Dawley Reperfusion Injury - drug therapy Reperfusion Injury - immunology Reperfusion Injury - metabolism
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