Pax: A murine multigene family of paired box-containing genes
A murine multigene family has been identified that shares a conserved sequence motif, the paired box, with developmental control and tissue-specific genes of Drosophila. To date five murine paired bo x -containing genes (Pax genes) have been described and one, Pax-1, has been associated with the dev...
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| Veröffentlicht in: | Genomics (San Diego, Calif.) Calif.), 1991-10, Vol.11 (2), p.424-434 |
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| container_title | Genomics (San Diego, Calif.) |
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| creator | Walther, Claudia Guenet, Jean-Louis Simon, Dominique Deutsch, Urban Jostes, Birgit Goulding, Martyn D. Plachov, Dimitrij Balling, Rudi Gruss, Peter |
| description | A murine multigene family has been identified that shares a conserved sequence motif, the paired box, with developmental control and tissue-specific genes of
Drosophila. To date five murine
paired bo
x
-containing genes (Pax genes) have been described and one,
Pax-1, has been associated with the developmental mutant phenotype
undulated. Here we describe the paired boxes of three novel Pax genes,
Pax-4, Pax-5, and
Pax-6. Comparison of the eight murine paired domains of the mouse, the five
Drosophila paired domains, and the three human paired domains shows that they fall into six distinct classes: class I comprises
Pox meso, Pax-1, and HuP48; class II
paired, gooseberry-proximal, gooseberry-distal, Pax-3, Pax-7, HuP1, and HuP2; class III
Pax-2, Pax-5, and
Pax-8; class IV
Pax-4; class V
Pox neuro; and class VI
Pax-6, Pax-1 and the human gene HuP48 have identical paired domains, as do
Pax-3 and HuP2 as well as
Pax-7 and HuP1, and are likely to represent homologous genes in mouse and man. Identical intron-exon structure and extensive sequence homology of their paired boxes suggest that several Pax genes represent paralogs. The chromosomal location of all novel Pax genes and of
Pax-3 and
Pax-7 has been determined and reveals that they are not clustered. |
| doi_str_mv | 10.1016/0888-7543(91)90151-4 |
| format | Article |
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Drosophila. To date five murine
paired bo
x
-containing genes (Pax genes) have been described and one,
Pax-1, has been associated with the developmental mutant phenotype
undulated. Here we describe the paired boxes of three novel Pax genes,
Pax-4, Pax-5, and
Pax-6. Comparison of the eight murine paired domains of the mouse, the five
Drosophila paired domains, and the three human paired domains shows that they fall into six distinct classes: class I comprises
Pox meso, Pax-1, and HuP48; class II
paired, gooseberry-proximal, gooseberry-distal, Pax-3, Pax-7, HuP1, and HuP2; class III
Pax-2, Pax-5, and
Pax-8; class IV
Pax-4; class V
Pox neuro; and class VI
Pax-6, Pax-1 and the human gene HuP48 have identical paired domains, as do
Pax-3 and HuP2 as well as
Pax-7 and HuP1, and are likely to represent homologous genes in mouse and man. Identical intron-exon structure and extensive sequence homology of their paired boxes suggest that several Pax genes represent paralogs. The chromosomal location of all novel Pax genes and of
Pax-3 and
Pax-7 has been determined and reveals that they are not clustered.</description><identifier>ISSN: 0888-7543</identifier><identifier>EISSN: 1089-8646</identifier><identifier>DOI: 10.1016/0888-7543(91)90151-4</identifier><identifier>PMID: 1685142</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>Amino Acid Sequence ; Animals ; Base Sequence ; Biological and medical sciences ; Chromosome Mapping ; Cloning, Molecular ; Crosses, Genetic ; DNA Probes ; Drosophila - genetics ; Fundamental and applied biological sciences. Psychology ; Genes, Regulator - genetics ; Genes. Genome ; Haplotypes ; Mice - genetics ; Molecular and cellular biology ; Molecular genetics ; Molecular Sequence Data ; Multigene Family - genetics ; Polymorphism, Restriction Fragment Length ; Reading Frames ; Sequence Alignment</subject><ispartof>Genomics (San Diego, Calif.), 1991-10, Vol.11 (2), p.424-434</ispartof><rights>1991</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-f3cc445785f07314d0d4518f98d1ca07af3d329bf555e0e630b072e3dd2041b23</citedby><cites>FETCH-LOGICAL-c417t-f3cc445785f07314d0d4518f98d1ca07af3d329bf555e0e630b072e3dd2041b23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0888-7543(91)90151-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4953970$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1685142$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Walther, Claudia</creatorcontrib><creatorcontrib>Guenet, Jean-Louis</creatorcontrib><creatorcontrib>Simon, Dominique</creatorcontrib><creatorcontrib>Deutsch, Urban</creatorcontrib><creatorcontrib>Jostes, Birgit</creatorcontrib><creatorcontrib>Goulding, Martyn D.</creatorcontrib><creatorcontrib>Plachov, Dimitrij</creatorcontrib><creatorcontrib>Balling, Rudi</creatorcontrib><creatorcontrib>Gruss, Peter</creatorcontrib><title>Pax: A murine multigene family of paired box-containing genes</title><title>Genomics (San Diego, Calif.)</title><addtitle>Genomics</addtitle><description>A murine multigene family has been identified that shares a conserved sequence motif, the paired box, with developmental control and tissue-specific genes of
Drosophila. To date five murine
paired bo
x
-containing genes (Pax genes) have been described and one,
Pax-1, has been associated with the developmental mutant phenotype
undulated. Here we describe the paired boxes of three novel Pax genes,
Pax-4, Pax-5, and
Pax-6. Comparison of the eight murine paired domains of the mouse, the five
Drosophila paired domains, and the three human paired domains shows that they fall into six distinct classes: class I comprises
Pox meso, Pax-1, and HuP48; class II
paired, gooseberry-proximal, gooseberry-distal, Pax-3, Pax-7, HuP1, and HuP2; class III
Pax-2, Pax-5, and
Pax-8; class IV
Pax-4; class V
Pox neuro; and class VI
Pax-6, Pax-1 and the human gene HuP48 have identical paired domains, as do
Pax-3 and HuP2 as well as
Pax-7 and HuP1, and are likely to represent homologous genes in mouse and man. Identical intron-exon structure and extensive sequence homology of their paired boxes suggest that several Pax genes represent paralogs. The chromosomal location of all novel Pax genes and of
Pax-3 and
Pax-7 has been determined and reveals that they are not clustered.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Chromosome Mapping</subject><subject>Cloning, Molecular</subject><subject>Crosses, Genetic</subject><subject>DNA Probes</subject><subject>Drosophila - genetics</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genes, Regulator - genetics</subject><subject>Genes. Genome</subject><subject>Haplotypes</subject><subject>Mice - genetics</subject><subject>Molecular and cellular biology</subject><subject>Molecular genetics</subject><subject>Molecular Sequence Data</subject><subject>Multigene Family - genetics</subject><subject>Polymorphism, Restriction Fragment Length</subject><subject>Reading Frames</subject><subject>Sequence Alignment</subject><issn>0888-7543</issn><issn>1089-8646</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLHUEQRhuJmOvjHyQwixDMYkxVP6a7hQREYhSEuEjWTU8_pGUe1-65Qf99ZnIvZmdWVVCnPqoOIe8QzhCw-QxKqVoKzk41ftKAAmu-R1YISteq4c0bsnpB3pLDUh4AQDNFD8gBNkogpyvy5c4-nVcXVb_JaQhz6aZ0H-Yu2j51z9UYq7VNOfiqHZ9qNw6TTUMa7qsFKsdkP9quhJNdPSK_rr79vLyub398v7m8uK0dRznVkTnHuZBKRJAMuQfPBaqolUdnQdrIPKO6jUKIAKFh0IKkgXlPgWNL2RH5uM1d5_FxE8pk-lRc6Do7hHFTjKQNAp___B-IDQpKlZxBvgVdHkvJIZp1Tr3NzwbBLHrN4s4s7oxG81evWfLf7_I3bR_8v6Wtz3n-YTe3xdkuZju4VF4wrgXTEmbs6xYLs7TfKWRTXAqDC35W7Sbjx_T6HX8AH4qUCw</recordid><startdate>19911001</startdate><enddate>19911001</enddate><creator>Walther, Claudia</creator><creator>Guenet, Jean-Louis</creator><creator>Simon, Dominique</creator><creator>Deutsch, Urban</creator><creator>Jostes, Birgit</creator><creator>Goulding, Martyn D.</creator><creator>Plachov, Dimitrij</creator><creator>Balling, Rudi</creator><creator>Gruss, Peter</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19911001</creationdate><title>Pax: A murine multigene family of paired box-containing genes</title><author>Walther, Claudia ; Guenet, Jean-Louis ; Simon, Dominique ; Deutsch, Urban ; Jostes, Birgit ; Goulding, Martyn D. ; Plachov, Dimitrij ; Balling, Rudi ; Gruss, Peter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-f3cc445785f07314d0d4518f98d1ca07af3d329bf555e0e630b072e3dd2041b23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Chromosome Mapping</topic><topic>Cloning, Molecular</topic><topic>Crosses, Genetic</topic><topic>DNA Probes</topic><topic>Drosophila - genetics</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genes, Regulator - genetics</topic><topic>Genes. Genome</topic><topic>Haplotypes</topic><topic>Mice - genetics</topic><topic>Molecular and cellular biology</topic><topic>Molecular genetics</topic><topic>Molecular Sequence Data</topic><topic>Multigene Family - genetics</topic><topic>Polymorphism, Restriction Fragment Length</topic><topic>Reading Frames</topic><topic>Sequence Alignment</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Walther, Claudia</creatorcontrib><creatorcontrib>Guenet, Jean-Louis</creatorcontrib><creatorcontrib>Simon, Dominique</creatorcontrib><creatorcontrib>Deutsch, Urban</creatorcontrib><creatorcontrib>Jostes, Birgit</creatorcontrib><creatorcontrib>Goulding, Martyn D.</creatorcontrib><creatorcontrib>Plachov, Dimitrij</creatorcontrib><creatorcontrib>Balling, Rudi</creatorcontrib><creatorcontrib>Gruss, Peter</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Genomics (San Diego, Calif.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Walther, Claudia</au><au>Guenet, Jean-Louis</au><au>Simon, Dominique</au><au>Deutsch, Urban</au><au>Jostes, Birgit</au><au>Goulding, Martyn D.</au><au>Plachov, Dimitrij</au><au>Balling, Rudi</au><au>Gruss, Peter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pax: A murine multigene family of paired box-containing genes</atitle><jtitle>Genomics (San Diego, Calif.)</jtitle><addtitle>Genomics</addtitle><date>1991-10-01</date><risdate>1991</risdate><volume>11</volume><issue>2</issue><spage>424</spage><epage>434</epage><pages>424-434</pages><issn>0888-7543</issn><eissn>1089-8646</eissn><abstract>A murine multigene family has been identified that shares a conserved sequence motif, the paired box, with developmental control and tissue-specific genes of
Drosophila. To date five murine
paired bo
x
-containing genes (Pax genes) have been described and one,
Pax-1, has been associated with the developmental mutant phenotype
undulated. Here we describe the paired boxes of three novel Pax genes,
Pax-4, Pax-5, and
Pax-6. Comparison of the eight murine paired domains of the mouse, the five
Drosophila paired domains, and the three human paired domains shows that they fall into six distinct classes: class I comprises
Pox meso, Pax-1, and HuP48; class II
paired, gooseberry-proximal, gooseberry-distal, Pax-3, Pax-7, HuP1, and HuP2; class III
Pax-2, Pax-5, and
Pax-8; class IV
Pax-4; class V
Pox neuro; and class VI
Pax-6, Pax-1 and the human gene HuP48 have identical paired domains, as do
Pax-3 and HuP2 as well as
Pax-7 and HuP1, and are likely to represent homologous genes in mouse and man. Identical intron-exon structure and extensive sequence homology of their paired boxes suggest that several Pax genes represent paralogs. The chromosomal location of all novel Pax genes and of
Pax-3 and
Pax-7 has been determined and reveals that they are not clustered.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>1685142</pmid><doi>10.1016/0888-7543(91)90151-4</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0888-7543 |
| ispartof | Genomics (San Diego, Calif.), 1991-10, Vol.11 (2), p.424-434 |
| issn | 0888-7543 1089-8646 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72610454 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Amino Acid Sequence Animals Base Sequence Biological and medical sciences Chromosome Mapping Cloning, Molecular Crosses, Genetic DNA Probes Drosophila - genetics Fundamental and applied biological sciences. Psychology Genes, Regulator - genetics Genes. Genome Haplotypes Mice - genetics Molecular and cellular biology Molecular genetics Molecular Sequence Data Multigene Family - genetics Polymorphism, Restriction Fragment Length Reading Frames Sequence Alignment |
| title | Pax: A murine multigene family of paired box-containing genes |
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