Engineering the Extracellular Matrix: A Novel Approach to Polymeric Biomaterials. I. Control of the Physical Properties of Artificial Protein Matrices Designed to Support Adhesion of Vascular Endothelial Cells

Methods of genetic engineering were applied to the design and biosynthesis of three extracellular matrix protein analogues constructed from identical elastin- and fibronectin-derived repeating units but characterized by different molecular weights in the range of 14 000 to 59 000. Expression levels...

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Veröffentlicht in:	Biomacromolecules 2000, Vol.1 (1), p.23-30
Hauptverfasser:	Welsh, Eric R, Tirrell, David A
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Biocompatible Materials Blotting, Western Cell Adhesion Chemical Phenomena Chemistry, Physical Cloning, Molecular Cross-Linking Reagents elastin Electrophoresis, Polyacrylamide Gel Endothelium, Vascular - cytology Extracellular Matrix - chemistry fibronectin glutaraldehyde Magnetic Resonance Spectroscopy Molecular Sequence Data Protein Engineering Recombinant Proteins - biosynthesis Recombinant Proteins - chemistry Recombinant Proteins - isolation & purification Solubility Tensile Strength
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