Pyrido[2,3-d]pyrimidin-7-one Inhibitors of Cyclin-Dependent Kinases

The identification of 8-ethyl-2-phenylamino-8H-pyrido[2,3-d]pyrimidin-7-one (1) as an inhibitor of Cdk4 led to the initiation of a program to evaluate related pyrido[2,3-d]pyrimidin-7-ones for inhibition of cyclin-dependent kinases (Cdks). Analysis of more than 60 analogues has identified some clear...

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Veröffentlicht in:	Journal of medicinal chemistry 2000-11, Vol.43 (24), p.4606-4616
Hauptverfasser:	Barvian, Mark, Boschelli, Diane H, Cossrow, Jennifer, Dobrusin, Ellen, Fattaey, Ali, Fritsch, Alex, Fry, David, Harvey, Patricia, Keller, Paul, Garrett, Michelle, La, Frances, Leopold, Wilbur, McNamara, Dennis, Quin, Maire, Trumpp-Kallmeyer, Susanne, Toogood, Peter, Wu, Zhipei, Zhang, Erli
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Animals Antineoplastic agents Biological and medical sciences CDC2-CDC28 Kinases Cell Division - drug effects Cell Line Crystallography, X-Ray Cyclin-Dependent Kinase 2 Cyclin-Dependent Kinase 4 Cyclin-Dependent Kinases - antagonists & inhibitors Cyclin-Dependent Kinases - metabolism Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology General aspects Humans Insecta - cytology Kinetics Medical sciences Models, Molecular Pharmacology. Drug treatments Protein-Serine-Threonine Kinases - metabolism Proto-Oncogene Proteins Pyrimidines - chemical synthesis Pyrimidines - chemistry Pyrimidines - pharmacology Recombinant Proteins - antagonists & inhibitors Structure-Activity Relationship
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