Effects of Cacao Liquor Polyphenols on the Susceptibility of Low-density Lipoprotein to Oxidation in Hypercholesterolemic Rabbits
The effects of cacao liquor polyphenols (CLP) on the susceptibility of low-density lipoprotein (LDL) to oxidation in hypercholesterolemic rabbits were examined. Six Japanese white rabbits which had been fed a high cholesterol diet (HCD) for 3 weeks were fed HCD containing 1% CLP for the following 10...
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| Veröffentlicht in: | Journal of Atherosclerosis and Thrombosis 2000, Vol.7(3), pp.164-168 |
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| container_title | Journal of Atherosclerosis and Thrombosis |
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| creator | Osakabe, Naomi Natsume, Midori Adachi, Toko Yamagishi, Megumi Hirano, Reiko Takizawa, Toshio Itakura, Hiroshige Kondo, Kazuo |
| description | The effects of cacao liquor polyphenols (CLP) on the susceptibility of low-density lipoprotein (LDL) to oxidation in hypercholesterolemic rabbits were examined. Six Japanese white rabbits which had been fed a high cholesterol diet (HCD) for 3 weeks were fed HCD containing 1% CLP for the following 10 days. The susceptibility of LDL to oxidation induced by 2-2'-azobis (4-methoxy-2, 4-dimethylvaleronitrile) (V-70) was evaluated by measuring the production of conjugated dienes and thiobarbituric acid reactive substances (TBARS). The lag time was significantly prolonged from 37.7 min before intake of CLP to 42.9, 44.2 and 45.8 min after 4, 7 and 10 days of CLP intake. TBARS production after intake of CLP was also markedly reduced compared with the level before intake. There was no difference in plasma lipid concentrations comparing the levels before and after CLP intake. In conclusion, in hypercholesterolemic rabbits, orally administered CLP was absorbed and distributed to the blood, and the resistance of LDL to oxidation was thereby increased. |
| doi_str_mv | 10.5551/jat1994.7.164 |
| format | Article |
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Six Japanese white rabbits which had been fed a high cholesterol diet (HCD) for 3 weeks were fed HCD containing 1% CLP for the following 10 days. The susceptibility of LDL to oxidation induced by 2-2'-azobis (4-methoxy-2, 4-dimethylvaleronitrile) (V-70) was evaluated by measuring the production of conjugated dienes and thiobarbituric acid reactive substances (TBARS). The lag time was significantly prolonged from 37.7 min before intake of CLP to 42.9, 44.2 and 45.8 min after 4, 7 and 10 days of CLP intake. TBARS production after intake of CLP was also markedly reduced compared with the level before intake. There was no difference in plasma lipid concentrations comparing the levels before and after CLP intake. In conclusion, in hypercholesterolemic rabbits, orally administered CLP was absorbed and distributed to the blood, and the resistance of LDL to oxidation was thereby increased.</description><identifier>ISSN: 1340-3478</identifier><identifier>EISSN: 1880-3873</identifier><identifier>DOI: 10.5551/jat1994.7.164</identifier><identifier>PMID: 11480458</identifier><language>eng</language><publisher>Japan: Japan Atherosclerosis Society</publisher><subject>Animals ; Antioxidants - isolation & purification ; Antioxidants - pharmacology ; Cacao - chemistry ; Cacao liquor ; Flavonoids ; Hypercholesterolemia - drug therapy ; Hypercholesterolemia - metabolism ; LDL ; Lipids - blood ; Lipoproteins, LDL - blood ; Lipoproteins, LDL - chemistry ; Male ; Oxidation ; Oxidation-Reduction ; Phenols - isolation & purification ; Phenols - pharmacology ; Polymers - isolation & purification ; Polymers - pharmacology ; Polyphenols ; Rabbits ; Thiobarbituric Acid Reactive Substances - metabolism</subject><ispartof>Journal of Atherosclerosis and Thrombosis, 2000, Vol.7(3), pp.164-168</ispartof><rights>Japan Atherosclerosis Society</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4924-49c625d6ac5f8c51780fd46f136490adc4f1b669a1e2290b043591fe138a868a3</citedby><cites>FETCH-LOGICAL-c4924-49c625d6ac5f8c51780fd46f136490adc4f1b669a1e2290b043591fe138a868a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,4010,27902,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11480458$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Osakabe, Naomi</creatorcontrib><creatorcontrib>Natsume, Midori</creatorcontrib><creatorcontrib>Adachi, Toko</creatorcontrib><creatorcontrib>Yamagishi, Megumi</creatorcontrib><creatorcontrib>Hirano, Reiko</creatorcontrib><creatorcontrib>Takizawa, Toshio</creatorcontrib><creatorcontrib>Itakura, Hiroshige</creatorcontrib><creatorcontrib>Kondo, Kazuo</creatorcontrib><title>Effects of Cacao Liquor Polyphenols on the Susceptibility of Low-density Lipoprotein to Oxidation in Hypercholesterolemic Rabbits</title><title>Journal of Atherosclerosis and Thrombosis</title><addtitle>JAT</addtitle><description>The effects of cacao liquor polyphenols (CLP) on the susceptibility of low-density lipoprotein (LDL) to oxidation in hypercholesterolemic rabbits were examined. Six Japanese white rabbits which had been fed a high cholesterol diet (HCD) for 3 weeks were fed HCD containing 1% CLP for the following 10 days. The susceptibility of LDL to oxidation induced by 2-2'-azobis (4-methoxy-2, 4-dimethylvaleronitrile) (V-70) was evaluated by measuring the production of conjugated dienes and thiobarbituric acid reactive substances (TBARS). The lag time was significantly prolonged from 37.7 min before intake of CLP to 42.9, 44.2 and 45.8 min after 4, 7 and 10 days of CLP intake. TBARS production after intake of CLP was also markedly reduced compared with the level before intake. There was no difference in plasma lipid concentrations comparing the levels before and after CLP intake. In conclusion, in hypercholesterolemic rabbits, orally administered CLP was absorbed and distributed to the blood, and the resistance of LDL to oxidation was thereby increased.</description><subject>Animals</subject><subject>Antioxidants - isolation & purification</subject><subject>Antioxidants - pharmacology</subject><subject>Cacao - chemistry</subject><subject>Cacao liquor</subject><subject>Flavonoids</subject><subject>Hypercholesterolemia - drug therapy</subject><subject>Hypercholesterolemia - metabolism</subject><subject>LDL</subject><subject>Lipids - blood</subject><subject>Lipoproteins, LDL - blood</subject><subject>Lipoproteins, LDL - chemistry</subject><subject>Male</subject><subject>Oxidation</subject><subject>Oxidation-Reduction</subject><subject>Phenols - isolation & purification</subject><subject>Phenols - pharmacology</subject><subject>Polymers - isolation & purification</subject><subject>Polymers - pharmacology</subject><subject>Polyphenols</subject><subject>Rabbits</subject><subject>Thiobarbituric Acid Reactive Substances - metabolism</subject><issn>1340-3478</issn><issn>1880-3873</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkE1v1DAQhi1ERUvhyBXlxC2LHX_EPlarQpEiFbXlbDnOmPUqG6e2o7JH_nm93VXhMJoZzTOvZl6EPhG84pyTr1uTiVJs1a6IYG_QBZES11S29G2pKSs1a-U5ep_SFmNKOW_eoXNCmMSMywv099o5sDlVwVVrY02oOv-4hFj9DON-3sAUxjKbqryB6n5JFubsez_6vD9sdOGpHmBKh7bzc5hjyOALHarbP34w2ZfV0t_sZ4h2E0ZIGWJJO2-rO9P3PqcP6MyZMcHHU75Ev75dP6xv6u72-4_1VVdbphpWM2VFwwdhLHfSctJK7AYmHKGCKWwGyxzphVCGQNMo3GNGuSIOCJVGCmnoJfpy1C1HPi7lEL3z5Z9xNBOEJem2EVhIxQtYH0EbQ0oRnJ6j35m41wTrg-f65LludfG88J9Pwku_g-EffTK5AFdHYJuy-Q2vgInZ2xH-k6MvUURfZ3ZjooaJPgNskJZ-</recordid><startdate>2000</startdate><enddate>2000</enddate><creator>Osakabe, Naomi</creator><creator>Natsume, Midori</creator><creator>Adachi, Toko</creator><creator>Yamagishi, Megumi</creator><creator>Hirano, Reiko</creator><creator>Takizawa, Toshio</creator><creator>Itakura, Hiroshige</creator><creator>Kondo, Kazuo</creator><general>Japan Atherosclerosis Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2000</creationdate><title>Effects of Cacao Liquor Polyphenols on the Susceptibility of Low-density Lipoprotein to Oxidation in Hypercholesterolemic Rabbits</title><author>Osakabe, Naomi ; 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Six Japanese white rabbits which had been fed a high cholesterol diet (HCD) for 3 weeks were fed HCD containing 1% CLP for the following 10 days. The susceptibility of LDL to oxidation induced by 2-2'-azobis (4-methoxy-2, 4-dimethylvaleronitrile) (V-70) was evaluated by measuring the production of conjugated dienes and thiobarbituric acid reactive substances (TBARS). The lag time was significantly prolonged from 37.7 min before intake of CLP to 42.9, 44.2 and 45.8 min after 4, 7 and 10 days of CLP intake. TBARS production after intake of CLP was also markedly reduced compared with the level before intake. There was no difference in plasma lipid concentrations comparing the levels before and after CLP intake. In conclusion, in hypercholesterolemic rabbits, orally administered CLP was absorbed and distributed to the blood, and the resistance of LDL to oxidation was thereby increased.</abstract><cop>Japan</cop><pub>Japan Atherosclerosis Society</pub><pmid>11480458</pmid><doi>10.5551/jat1994.7.164</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Antioxidants - isolation & purification Antioxidants - pharmacology Cacao - chemistry Cacao liquor Flavonoids Hypercholesterolemia - drug therapy Hypercholesterolemia - metabolism LDL Lipids - blood Lipoproteins, LDL - blood Lipoproteins, LDL - chemistry Male Oxidation Oxidation-Reduction Phenols - isolation & purification Phenols - pharmacology Polymers - isolation & purification Polymers - pharmacology Polyphenols Rabbits Thiobarbituric Acid Reactive Substances - metabolism |
| title | Effects of Cacao Liquor Polyphenols on the Susceptibility of Low-density Lipoprotein to Oxidation in Hypercholesterolemic Rabbits |
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