Bronchial smooth muscle responses evoked by toluene diisocyanate are inhibited by ruthenium red and by indomethacin
We have investigated the ability of ruthenium red, an inorganic dye with Ca 2+ entry-blocking properties and a selective antagonist of capsaicin, and of indomethacin, a cyclooxygenase inhibitor, to inhibit bronchial smooth muscle responses evoked by toluene diisocyanate in guinea pigs. Previous expo...
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| Veröffentlicht in: | European journal of pharmacology 1991-07, Vol.200 (1), p.73-76 |
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| container_title | European journal of pharmacology |
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| creator | Mapp, Cristina E. Boniotti, Anna Graf, Paul D. Chitano, Pasquale Fabbri, Leonardo M. Nadel, Jay A. |
| description | We have investigated the ability of ruthenium red, an inorganic dye with Ca
2+ entry-blocking properties and a selective antagonist of capsaicin, and of indomethacin, a cyclooxygenase inhibitor, to inhibit bronchial smooth muscle responses evoked by toluene diisocyanate in guinea pigs. Previous exposure of isolated guinea pig bronchi to ruthenium red significantly decreased the response produced by toluene diisocyanate. Further, the response to toluene diisocyanate was significantly decreased by pretreatment with indomethacin. These findings provide evidence that toluene diisocyanate-induced contractions of guinea pig bronchi are produced indirectly by generation of a prostanoid that activates capsaicin-sensitive afferents via a ruthenium red-sensitive mechanism. |
| doi_str_mv | 10.1016/0014-2999(91)90667-F |
| format | Article |
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2+ entry-blocking properties and a selective antagonist of capsaicin, and of indomethacin, a cyclooxygenase inhibitor, to inhibit bronchial smooth muscle responses evoked by toluene diisocyanate in guinea pigs. Previous exposure of isolated guinea pig bronchi to ruthenium red significantly decreased the response produced by toluene diisocyanate. Further, the response to toluene diisocyanate was significantly decreased by pretreatment with indomethacin. These findings provide evidence that toluene diisocyanate-induced contractions of guinea pig bronchi are produced indirectly by generation of a prostanoid that activates capsaicin-sensitive afferents via a ruthenium red-sensitive mechanism.</description><identifier>ISSN: 0014-2999</identifier><identifier>EISSN: 1879-0712</identifier><identifier>DOI: 10.1016/0014-2999(91)90667-F</identifier><identifier>PMID: 1722756</identifier><identifier>CODEN: EJPHAZ</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Animals ; Asthma ; Biological and medical sciences ; Bronchi ; Chemical and industrial products toxicology. Toxic occupational diseases ; Guinea Pigs ; Indomethacin - pharmacology ; Male ; Medical sciences ; Muscle Contraction - drug effects ; Muscle, Smooth - drug effects ; Muscle, Smooth - physiology ; Prostaglandins ; Ruthenium Red - pharmacology ; Sensory nerves ; Toluene 2,4-Diisocyanate - antagonists & inhibitors ; Toluene 2,4-Diisocyanate - pharmacology ; Toluene diisocyanate ; Toxicology ; Various organic compounds</subject><ispartof>European journal of pharmacology, 1991-07, Vol.200 (1), p.73-76</ispartof><rights>1991</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c387t-19eec6e7eaa29ab52a235b991c9e3a423c967fb60d20c8c2c9caddda009231403</citedby><cites>FETCH-LOGICAL-c387t-19eec6e7eaa29ab52a235b991c9e3a423c967fb60d20c8c2c9caddda009231403</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0014-2999(91)90667-F$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19840536$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1722756$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mapp, Cristina E.</creatorcontrib><creatorcontrib>Boniotti, Anna</creatorcontrib><creatorcontrib>Graf, Paul D.</creatorcontrib><creatorcontrib>Chitano, Pasquale</creatorcontrib><creatorcontrib>Fabbri, Leonardo M.</creatorcontrib><creatorcontrib>Nadel, Jay A.</creatorcontrib><title>Bronchial smooth muscle responses evoked by toluene diisocyanate are inhibited by ruthenium red and by indomethacin</title><title>European journal of pharmacology</title><addtitle>Eur J Pharmacol</addtitle><description>We have investigated the ability of ruthenium red, an inorganic dye with Ca
2+ entry-blocking properties and a selective antagonist of capsaicin, and of indomethacin, a cyclooxygenase inhibitor, to inhibit bronchial smooth muscle responses evoked by toluene diisocyanate in guinea pigs. Previous exposure of isolated guinea pig bronchi to ruthenium red significantly decreased the response produced by toluene diisocyanate. Further, the response to toluene diisocyanate was significantly decreased by pretreatment with indomethacin. These findings provide evidence that toluene diisocyanate-induced contractions of guinea pig bronchi are produced indirectly by generation of a prostanoid that activates capsaicin-sensitive afferents via a ruthenium red-sensitive mechanism.</description><subject>Animals</subject><subject>Asthma</subject><subject>Biological and medical sciences</subject><subject>Bronchi</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Guinea Pigs</subject><subject>Indomethacin - pharmacology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Muscle Contraction - drug effects</subject><subject>Muscle, Smooth - drug effects</subject><subject>Muscle, Smooth - physiology</subject><subject>Prostaglandins</subject><subject>Ruthenium Red - pharmacology</subject><subject>Sensory nerves</subject><subject>Toluene 2,4-Diisocyanate - antagonists & inhibitors</subject><subject>Toluene 2,4-Diisocyanate - pharmacology</subject><subject>Toluene diisocyanate</subject><subject>Toxicology</subject><subject>Various organic compounds</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1v1DAQhi0EKtvCPwDJFxAcUmzn05dKUHWhUqVe4GxNxrOKIbEX26m0_77ZZkVvnEaaed5Xo4exd1JcSiGbL0LIqlBa609aftaiadpi-4JtZNfqQrRSvWSbf8hrdp7SbyFErVV9xs5kq1RbNxuWvsXgcXAw8jSFkAc-zQlH4pHSPvhEidND-EOW9weewziTJ26dSwEP4CETh0jc-cH1Lq9UnPNA3s3T0mE5-Kel8zZMlAdA59-wVzsYE709zQv2a3vz8_pHcXf__fb6612BZdfmQmoibKglAKWhrxWosu61lqiphEqVqJt21zfCKoEdKtQI1loQQqtSVqK8YB_X3n0Mf2dK2UwuIY0jeApzMq1qFmtNt4DVCmIMKUXamX10E8SDkcIcXZujSHMUabQ0T67Ndom9P_XP_UT2ObTKXe4fTndICOMugkeXnjHdVaIuj9zVytEi48FRNAkdeSTrImE2Nrj_P_II7vadgg</recordid><startdate>19910723</startdate><enddate>19910723</enddate><creator>Mapp, Cristina E.</creator><creator>Boniotti, Anna</creator><creator>Graf, Paul D.</creator><creator>Chitano, Pasquale</creator><creator>Fabbri, Leonardo M.</creator><creator>Nadel, Jay A.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19910723</creationdate><title>Bronchial smooth muscle responses evoked by toluene diisocyanate are inhibited by ruthenium red and by indomethacin</title><author>Mapp, Cristina E. ; Boniotti, Anna ; Graf, Paul D. ; Chitano, Pasquale ; Fabbri, Leonardo M. ; Nadel, Jay A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387t-19eec6e7eaa29ab52a235b991c9e3a423c967fb60d20c8c2c9caddda009231403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Animals</topic><topic>Asthma</topic><topic>Biological and medical sciences</topic><topic>Bronchi</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>Guinea Pigs</topic><topic>Indomethacin - pharmacology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Muscle Contraction - drug effects</topic><topic>Muscle, Smooth - drug effects</topic><topic>Muscle, Smooth - physiology</topic><topic>Prostaglandins</topic><topic>Ruthenium Red - pharmacology</topic><topic>Sensory nerves</topic><topic>Toluene 2,4-Diisocyanate - antagonists & inhibitors</topic><topic>Toluene 2,4-Diisocyanate - pharmacology</topic><topic>Toluene diisocyanate</topic><topic>Toxicology</topic><topic>Various organic compounds</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mapp, Cristina E.</creatorcontrib><creatorcontrib>Boniotti, Anna</creatorcontrib><creatorcontrib>Graf, Paul D.</creatorcontrib><creatorcontrib>Chitano, Pasquale</creatorcontrib><creatorcontrib>Fabbri, Leonardo M.</creatorcontrib><creatorcontrib>Nadel, Jay A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mapp, Cristina E.</au><au>Boniotti, Anna</au><au>Graf, Paul D.</au><au>Chitano, Pasquale</au><au>Fabbri, Leonardo M.</au><au>Nadel, Jay A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bronchial smooth muscle responses evoked by toluene diisocyanate are inhibited by ruthenium red and by indomethacin</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>1991-07-23</date><risdate>1991</risdate><volume>200</volume><issue>1</issue><spage>73</spage><epage>76</epage><pages>73-76</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><coden>EJPHAZ</coden><abstract>We have investigated the ability of ruthenium red, an inorganic dye with Ca
2+ entry-blocking properties and a selective antagonist of capsaicin, and of indomethacin, a cyclooxygenase inhibitor, to inhibit bronchial smooth muscle responses evoked by toluene diisocyanate in guinea pigs. Previous exposure of isolated guinea pig bronchi to ruthenium red significantly decreased the response produced by toluene diisocyanate. Further, the response to toluene diisocyanate was significantly decreased by pretreatment with indomethacin. These findings provide evidence that toluene diisocyanate-induced contractions of guinea pig bronchi are produced indirectly by generation of a prostanoid that activates capsaicin-sensitive afferents via a ruthenium red-sensitive mechanism.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>1722756</pmid><doi>10.1016/0014-2999(91)90667-F</doi><tpages>4</tpages></addata></record> |
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| ispartof | European journal of pharmacology, 1991-07, Vol.200 (1), p.73-76 |
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| language | eng |
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| subjects | Animals Asthma Biological and medical sciences Bronchi Chemical and industrial products toxicology. Toxic occupational diseases Guinea Pigs Indomethacin - pharmacology Male Medical sciences Muscle Contraction - drug effects Muscle, Smooth - drug effects Muscle, Smooth - physiology Prostaglandins Ruthenium Red - pharmacology Sensory nerves Toluene 2,4-Diisocyanate - antagonists & inhibitors Toluene 2,4-Diisocyanate - pharmacology Toluene diisocyanate Toxicology Various organic compounds |
| title | Bronchial smooth muscle responses evoked by toluene diisocyanate are inhibited by ruthenium red and by indomethacin |
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