Endothelin-1 pathway in human alveolar epithelial cell line A549 and human umbilical vein endothelial cells

This study was designed to characterize the endothelin pathway in an immortalized human adenocarcinoma-derived alveolar epithelial cell line (A549) and human umbilical vein endothelial cell line (HUVEC). The release of ET-1 and big-ET-1 was measured in the incubation medium of both cell lines. The e...

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Veröffentlicht in:	Acta pharmacologica Sinica 2000-06, Vol.21 (6), p.499-506
Hauptverfasser:	Deprez-Roy, I, Coge, F, Bertry, L, Galizzi, J P, Feletou, M, Vanhoutte, P M, Canet, E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - pathology Aspartic Acid Endopeptidases - biosynthesis Aspartic Acid Endopeptidases - genetics Cells, Cultured Endothelin-1 - secretion Endothelin-Converting Enzymes Endothelins - biosynthesis Endothelins - genetics Endothelium, Vascular - cytology Endothelium, Vascular - metabolism Glycopeptides - pharmacology Humans Lung Neoplasms - pathology Metalloendopeptidases Protein Precursors - biosynthesis Protein Precursors - genetics RNA, Messenger - biosynthesis Tumor Cells, Cultured Umbilical Veins - cytology Umbilical Veins - metabolism
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