Influence of dose on the distribution kinetics of ciprofloxacin and ofloxacin in the isolated hindlimb of the rat
The aim of this study was to determine whether the dose influences the distribution kinetics of ciprofloxacin and ofloxacin in muscle‐ bone‐ and skin‐tissues included in the isolated hindlimb of the rat. Experiments were carried out in the isolated perfused hindlimb of the rat, administering a singl...
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| Veröffentlicht in: | Biopharmaceutics & drug disposition 2000-11, Vol.21 (8), p.313-319 |
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| creator | Casquero-Dorado, A.C. Colino, C.I. Martínez, M.S Sánchez-Navarro, A. |
| description | The aim of this study was to determine whether the dose influences the distribution kinetics of ciprofloxacin and ofloxacin in muscle‐ bone‐ and skin‐tissues included in the isolated hindlimb of the rat. Experiments were carried out in the isolated perfused hindlimb of the rat, administering a single dose of 45, 450 or 900 µg of each quinolone as a bolus injection. Outflow perfusate samples were collected for 20 min and drug levels were determined by an HPLC technique. The mean transit time (MTT) and the distribution volume of ciprofloxacin significantly increased with the dose injected (MTT=1.47±0.69, 8.74±0.27 and 9.52±2.95 min for 45, 450 and 900 µg, respectively). A similar situation was observed with ofloxacin, although the increase in these parameters was less pronounced (MTT=3.65±0.86, 7.92±2.03 and 8.32±1.70 min for 45, 450 and 900 µg, respectively). The distribution of ciprofloxacin and ofloxacin in the rat hindlimb appears to be a dose‐dependent process, at least for the dose range considered in this study. This might explain the high variability in the distribution coefficients reported for these drugs in literature. Copyright © 2000 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/bdd.245 |
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Experiments were carried out in the isolated perfused hindlimb of the rat, administering a single dose of 45, 450 or 900 µg of each quinolone as a bolus injection. Outflow perfusate samples were collected for 20 min and drug levels were determined by an HPLC technique. The mean transit time (MTT) and the distribution volume of ciprofloxacin significantly increased with the dose injected (MTT=1.47±0.69, 8.74±0.27 and 9.52±2.95 min for 45, 450 and 900 µg, respectively). A similar situation was observed with ofloxacin, although the increase in these parameters was less pronounced (MTT=3.65±0.86, 7.92±2.03 and 8.32±1.70 min for 45, 450 and 900 µg, respectively). The distribution of ciprofloxacin and ofloxacin in the rat hindlimb appears to be a dose‐dependent process, at least for the dose range considered in this study. This might explain the high variability in the distribution coefficients reported for these drugs in literature. Copyright © 2000 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0142-2782</identifier><identifier>EISSN: 1099-081X</identifier><identifier>DOI: 10.1002/bdd.245</identifier><identifier>PMID: 11514950</identifier><identifier>CODEN: BDDID8</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Algorithms ; Animals ; Anti-Infective Agents - administration & dosage ; Anti-Infective Agents - pharmacokinetics ; Antibacterial agents ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Biological and medical sciences ; ciprofloxacin ; Ciprofloxacin - administration & dosage ; Ciprofloxacin - pharmacokinetics ; dose-dependent kinetics ; Female ; Hindlimb - metabolism ; In Vitro Techniques ; isolated hindlimb ; Medical sciences ; ofloxacin ; Ofloxacin - administration & dosage ; Ofloxacin - pharmacokinetics ; Pharmaceutical Preparations - metabolism ; Pharmacology. Drug treatments ; Protein Binding ; quinolones distribution ; Rats ; Rats, Wistar</subject><ispartof>Biopharmaceutics & drug disposition, 2000-11, Vol.21 (8), p.313-319</ispartof><rights>Copyright © 2000 John Wiley & Sons, Ltd.</rights><rights>2001 INIST-CNRS</rights><rights>Copyright 2000 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3425-f609c214e89f79eaca83be237317365a5c28c8e6765602c12bef63070b3d23a63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fbdd.245$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fbdd.245$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1093336$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11514950$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Casquero-Dorado, A.C.</creatorcontrib><creatorcontrib>Colino, C.I.</creatorcontrib><creatorcontrib>Martínez, M.S</creatorcontrib><creatorcontrib>Sánchez-Navarro, A.</creatorcontrib><title>Influence of dose on the distribution kinetics of ciprofloxacin and ofloxacin in the isolated hindlimb of the rat</title><title>Biopharmaceutics & drug disposition</title><addtitle>Biopharm. Drug Dispos</addtitle><description>The aim of this study was to determine whether the dose influences the distribution kinetics of ciprofloxacin and ofloxacin in muscle‐ bone‐ and skin‐tissues included in the isolated hindlimb of the rat. Experiments were carried out in the isolated perfused hindlimb of the rat, administering a single dose of 45, 450 or 900 µg of each quinolone as a bolus injection. Outflow perfusate samples were collected for 20 min and drug levels were determined by an HPLC technique. The mean transit time (MTT) and the distribution volume of ciprofloxacin significantly increased with the dose injected (MTT=1.47±0.69, 8.74±0.27 and 9.52±2.95 min for 45, 450 and 900 µg, respectively). A similar situation was observed with ofloxacin, although the increase in these parameters was less pronounced (MTT=3.65±0.86, 7.92±2.03 and 8.32±1.70 min for 45, 450 and 900 µg, respectively). The distribution of ciprofloxacin and ofloxacin in the rat hindlimb appears to be a dose‐dependent process, at least for the dose range considered in this study. This might explain the high variability in the distribution coefficients reported for these drugs in literature. Copyright © 2000 John Wiley & Sons, Ltd.</description><subject>Algorithms</subject><subject>Animals</subject><subject>Anti-Infective Agents - administration & dosage</subject><subject>Anti-Infective Agents - pharmacokinetics</subject><subject>Antibacterial agents</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Biological and medical sciences</subject><subject>ciprofloxacin</subject><subject>Ciprofloxacin - administration & dosage</subject><subject>Ciprofloxacin - pharmacokinetics</subject><subject>dose-dependent kinetics</subject><subject>Female</subject><subject>Hindlimb - metabolism</subject><subject>In Vitro Techniques</subject><subject>isolated hindlimb</subject><subject>Medical sciences</subject><subject>ofloxacin</subject><subject>Ofloxacin - administration & dosage</subject><subject>Ofloxacin - pharmacokinetics</subject><subject>Pharmaceutical Preparations - metabolism</subject><subject>Pharmacology. Drug treatments</subject><subject>Protein Binding</subject><subject>quinolones distribution</subject><subject>Rats</subject><subject>Rats, Wistar</subject><issn>0142-2782</issn><issn>1099-081X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1P3DAQhq0KVBao-g9QDqg9VKH-SOzkWHZhQaLlQtW9WY49FgavA3aiwr-vo6xKLz2NZuaZd0bvIPSR4DOCMf3aGXNGq_odWhDctiVuyGYPLTCpaElFQw_QYUoPGGNOCHmPDgipSdXWeIGer4P1IwQNRW8L06ccQzHcQ2FcGqLrxsHlwqMLMDidJki7p9hb378o7UKhgineMjfPutR7NYAp7l0w3m27aW5qRDUco32rfIIPu3iEfl5e3C2vypvb9fXy202pWUXr0nLcakoqaForWlBaNawDygQjgvFa1Zo2ugEueM0x1YR2YDnDAnfMUKY4O0KfZt187fMIaZBblzR4rwL0Y5KCclxRVmXw8wzq2KcUwcqn6LYqvkqC5eSuzO7K7G4mT3aSY7cF88bt7MzA6Q5QSStvowrapX_0WsbYdNqXGfvtPLz-b508X63mreVM54fAy19axUfJBRO1_PVjLdfnd6vNcvNdXrI_FG-e8Q</recordid><startdate>200011</startdate><enddate>200011</enddate><creator>Casquero-Dorado, A.C.</creator><creator>Colino, C.I.</creator><creator>Martínez, M.S</creator><creator>Sánchez-Navarro, A.</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200011</creationdate><title>Influence of dose on the distribution kinetics of ciprofloxacin and ofloxacin in the isolated hindlimb of the rat</title><author>Casquero-Dorado, A.C. ; Colino, C.I. ; Martínez, M.S ; Sánchez-Navarro, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3425-f609c214e89f79eaca83be237317365a5c28c8e6765602c12bef63070b3d23a63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Algorithms</topic><topic>Animals</topic><topic>Anti-Infective Agents - administration & dosage</topic><topic>Anti-Infective Agents - pharmacokinetics</topic><topic>Antibacterial agents</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Biological and medical sciences</topic><topic>ciprofloxacin</topic><topic>Ciprofloxacin - administration & dosage</topic><topic>Ciprofloxacin - pharmacokinetics</topic><topic>dose-dependent kinetics</topic><topic>Female</topic><topic>Hindlimb - metabolism</topic><topic>In Vitro Techniques</topic><topic>isolated hindlimb</topic><topic>Medical sciences</topic><topic>ofloxacin</topic><topic>Ofloxacin - administration & dosage</topic><topic>Ofloxacin - pharmacokinetics</topic><topic>Pharmaceutical Preparations - metabolism</topic><topic>Pharmacology. Drug treatments</topic><topic>Protein Binding</topic><topic>quinolones distribution</topic><topic>Rats</topic><topic>Rats, Wistar</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Casquero-Dorado, A.C.</creatorcontrib><creatorcontrib>Colino, C.I.</creatorcontrib><creatorcontrib>Martínez, M.S</creatorcontrib><creatorcontrib>Sánchez-Navarro, A.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biopharmaceutics & drug disposition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Casquero-Dorado, A.C.</au><au>Colino, C.I.</au><au>Martínez, M.S</au><au>Sánchez-Navarro, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of dose on the distribution kinetics of ciprofloxacin and ofloxacin in the isolated hindlimb of the rat</atitle><jtitle>Biopharmaceutics & drug disposition</jtitle><addtitle>Biopharm. Drug Dispos</addtitle><date>2000-11</date><risdate>2000</risdate><volume>21</volume><issue>8</issue><spage>313</spage><epage>319</epage><pages>313-319</pages><issn>0142-2782</issn><eissn>1099-081X</eissn><coden>BDDID8</coden><abstract>The aim of this study was to determine whether the dose influences the distribution kinetics of ciprofloxacin and ofloxacin in muscle‐ bone‐ and skin‐tissues included in the isolated hindlimb of the rat. Experiments were carried out in the isolated perfused hindlimb of the rat, administering a single dose of 45, 450 or 900 µg of each quinolone as a bolus injection. Outflow perfusate samples were collected for 20 min and drug levels were determined by an HPLC technique. The mean transit time (MTT) and the distribution volume of ciprofloxacin significantly increased with the dose injected (MTT=1.47±0.69, 8.74±0.27 and 9.52±2.95 min for 45, 450 and 900 µg, respectively). A similar situation was observed with ofloxacin, although the increase in these parameters was less pronounced (MTT=3.65±0.86, 7.92±2.03 and 8.32±1.70 min for 45, 450 and 900 µg, respectively). The distribution of ciprofloxacin and ofloxacin in the rat hindlimb appears to be a dose‐dependent process, at least for the dose range considered in this study. This might explain the high variability in the distribution coefficients reported for these drugs in literature. Copyright © 2000 John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>11514950</pmid><doi>10.1002/bdd.245</doi><tpages>7</tpages></addata></record> |
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| subjects | Algorithms Animals Anti-Infective Agents - administration & dosage Anti-Infective Agents - pharmacokinetics Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences ciprofloxacin Ciprofloxacin - administration & dosage Ciprofloxacin - pharmacokinetics dose-dependent kinetics Female Hindlimb - metabolism In Vitro Techniques isolated hindlimb Medical sciences ofloxacin Ofloxacin - administration & dosage Ofloxacin - pharmacokinetics Pharmaceutical Preparations - metabolism Pharmacology. Drug treatments Protein Binding quinolones distribution Rats Rats, Wistar |
| title | Influence of dose on the distribution kinetics of ciprofloxacin and ofloxacin in the isolated hindlimb of the rat |
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