Mechanisms of endothelin-1-induced contraction in isolated placental veins from normal full-term and preterm pregnancies

This study characterizes the reactivity of human chorionic plate vein in full-term (39.4±0.3 weeks of gestation) and preterm (34.4±0.6 weeks of gestation) pregnancy to endothelin-1 (ET-1) and attempts to characterize ET-1 receptor subtype, and the contribution of nitric oxide and cyclooxygenase prod...

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Veröffentlicht in:	General pharmacology 2000-05, Vol.34 (5), p.295-301
Hauptverfasser:	Gallardo, Victoria, Cruz, M.Antonieta, Miguel, Patricia, Carrasco, Gonzalo, González, Clemente
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Blood vessels and receptors Endothelin Receptor Antagonists Endothelin-1 Endothelin-1 - physiology ET A and ET B receptors Female Full-term pregnancy Fundamental and applied biological sciences. Psychology Gestational Age Hormone metabolism and regulation Human placental vein Humans Indomethacin - pharmacology Infant, Newborn Infant, Premature Maternal Age Placenta - blood supply Placenta - drug effects Pregnancy Pregnancy Trimester, Third - blood Pregnancy. Parturition. Lactation Preterm pregnancy Receptor, Endothelin A Uterine Contraction - physiology Vasoconstriction - physiology Vasodilator Agents - pharmacology Veins - drug effects Vertebrates: cardiovascular system Vertebrates: reproduction
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