Stable Multicopy Vectors for High-Level Secretion of Recombinant Human Serum Albumin by Kluyveromyces Yeasts

We have designed stable pKD1 derivatives for efficient secretion of recombinant human serum albumin (rHSA) by industrial strains of Kluyveromyces yeasts. A comparison of this multi–copy expression system with isogenic cassettes integrated at chromosomal loci demonstrated that high level secretion of...

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Veröffentlicht in:	Bio/Technology 1991-10, Vol.9 (10), p.968-975
Hauptverfasser:	Fleer, R, Yeh, P, Amellal, N, Maury, I, Fournier, A, Bacchetta, F, Baduel, P, Jung, G, L'Hôte, H, Becquart, J, Fukuhara, H, Mayaux, J. F
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Base Sequence Bioinformatics Biological and medical sciences Biomedical and Life Sciences Biomedical Engineering/Biotechnology Biomedicine Biotechnology Biotechnology - methods Codon - genetics Fermentation Fundamental and applied biological sciences. Psychology Gene Expression Genetic Vectors Humans Kluyveromyces - genetics Life Sciences Methods. Procedures. Technologies Molecular Sequence Data Promoter Regions, Genetic Recombinant Proteins - biosynthesis research-paper Restriction Mapping Serum Albumin - biosynthesis Serum Albumin - genetics
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