The 21- and 23-kD forms of TCRζ are generated by specific ITAM phosphorylations

The T cell receptor (TCR) ζ subunit contains three immunoreceptor tyrosine-based activation motifs (ITAMs) that translate effective extracellular ligand binding into intracellular signals by becoming phosphorylated into 21- and 23-kD forms. We report here that the 21-kD form of TCRζ is generated by...

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Veröffentlicht in:	Nature immunology 2000-10, Vol.1 (4), p.322-328
Hauptverfasser:	van Oers, Nicolai S. C, Tohlen, Brett, Malissen, Bernard, Moomaw, Carolyn R, Afendis, Steve, Slaughter, Clive A
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Biomedical and Life Sciences Biomedicine COS Cells Immunology immunoreceptor tyrosine-based activation motif Infectious Diseases Membrane Proteins - genetics Membrane Proteins - metabolism Mice Mice, Transgenic Molecular Sequence Data Phosphorylation Receptors, Antigen, T-Cell - genetics Receptors, Antigen, T-Cell - metabolism Signal Transduction
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