Pharmacokinetics of verapamil in lactating rabbits: Prediction of verapamil distribution into rabbit milk
In this work, we have studied the pharmacokinetics and milk penetration of verapamil following intravenous administration in lactating rabbits. Milk-to-serum drug concentration ratios (M/B obs) have been determined using area under the milk and serum concentration–time profiles, and the resulting va...
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| Veröffentlicht in: | General pharmacology 2000-04, Vol.34 (4), p.237-243 |
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| creator | Solans, Carlos Aramayona, José Javier Bregante, Miguel Angel Fraile, Lorenzo José Rueda, Silvia Garcia, Marı́a Angeles |
| description | In this work, we have studied the pharmacokinetics and milk penetration of verapamil following intravenous administration in lactating rabbits. Milk-to-serum drug concentration ratios (M/B
obs) have been determined using area under the milk and serum concentration–time profiles, and the resulting values have then been compared with those obtained by theoretical classical diffusion milk transfer models that were described by Fleishaker et al. [J. Pharm. Sci. 76 (1987) 189.], Atkinson and Begg [Br. J. Clin. Pharmacol. 25 (1990) 495.], and Stebler and Guentert [Pharm. Res. 9 (1992) 1299.]. The pharmacokinetic profile of verapamil in lactating rabbits following endovenous administration is described in the form of a two-compartment model. Moreover, we detected an important milk transfer after endovenous administration of verapamil in lactating rabbits. M/B
obs was near 15. The classical diffusional models mentioned were not able to predict this extensive transfer of verapamil into rabbit milk. However, when the classical Fleishaker equation was modified and a stepwise regression was carried out, we found that the M/B
obs value could be predicted using the plasma and milk protein binding. |
| doi_str_mv | 10.1016/S0306-3623(00)00066-5 |
| format | Article |
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obs) have been determined using area under the milk and serum concentration–time profiles, and the resulting values have then been compared with those obtained by theoretical classical diffusion milk transfer models that were described by Fleishaker et al. [J. Pharm. Sci. 76 (1987) 189.], Atkinson and Begg [Br. J. Clin. Pharmacol. 25 (1990) 495.], and Stebler and Guentert [Pharm. Res. 9 (1992) 1299.]. The pharmacokinetic profile of verapamil in lactating rabbits following endovenous administration is described in the form of a two-compartment model. Moreover, we detected an important milk transfer after endovenous administration of verapamil in lactating rabbits. M/B
obs was near 15. The classical diffusional models mentioned were not able to predict this extensive transfer of verapamil into rabbit milk. However, when the classical Fleishaker equation was modified and a stepwise regression was carried out, we found that the M/B
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obs) have been determined using area under the milk and serum concentration–time profiles, and the resulting values have then been compared with those obtained by theoretical classical diffusion milk transfer models that were described by Fleishaker et al. [J. Pharm. Sci. 76 (1987) 189.], Atkinson and Begg [Br. J. Clin. Pharmacol. 25 (1990) 495.], and Stebler and Guentert [Pharm. Res. 9 (1992) 1299.]. The pharmacokinetic profile of verapamil in lactating rabbits following endovenous administration is described in the form of a two-compartment model. Moreover, we detected an important milk transfer after endovenous administration of verapamil in lactating rabbits. M/B
obs was near 15. The classical diffusional models mentioned were not able to predict this extensive transfer of verapamil into rabbit milk. However, when the classical Fleishaker equation was modified and a stepwise regression was carried out, we found that the M/B
obs value could be predicted using the plasma and milk protein binding.</description><subject>Animals</subject><subject>Antiarythmic agents</subject><subject>Binding Sites</subject><subject>Biological and medical sciences</subject><subject>Calcium Channel Blockers - pharmacokinetics</subject><subject>Cardiovascular system</subject><subject>Female</subject><subject>Infusions, Intravenous</subject><subject>Lactation - metabolism</subject><subject>Medical sciences</subject><subject>Milk</subject><subject>Milk - chemistry</subject><subject>Milk composition</subject><subject>Milk-to-blood drug concentration ratio</subject><subject>Pharmacology. Drug treatments</subject><subject>Rabbits</subject><subject>Verapamil</subject><subject>Verapamil - pharmacokinetics</subject><issn>0306-3623</issn><issn>1879-0011</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpV0U1LHEEQBuAmRLLrJj_BMBAQPYzpj5nuaS8iojGwoJDk3NT01GjF-Vi7exfy7x3XdSGnOtRTBVUvY0eCnwku9PdfXHGdKy3VCeennHOt8_IDm4vK2JxzIT6y-Z7M2GGMfyckSyk_sZkQspJSmDmj-0cIPfjxiQZM5GM2ttkGA6ygpy6jIevAJ0g0PGQB6ppSPM_uAzbkE43D_7qhmALV622HhjTuRrKp-fSZHbTQRfyyqwv25-b699Vtvrz78fPqcpmjtCLlpa_B6EorqbQHWegWQUAhvDB1YQGEBw3KGmMRZdUiQlMr9MaWplJFAWrBjt_2rsL4vMaYXE_RY9fBgOM6OiNLW-nKTvDrDq7rHhu3CtRD-OfenzOBbzsA0UPXBhg8xb2zqpC6mNTFm8LpqA1hcNETDn56UUCfXDOSE9y9hua2obnXRBznbhuaK9ULLzmJ9A</recordid><startdate>20000401</startdate><enddate>20000401</enddate><creator>Solans, Carlos</creator><creator>Aramayona, José Javier</creator><creator>Bregante, Miguel Angel</creator><creator>Fraile, Lorenzo José</creator><creator>Rueda, Silvia</creator><creator>Garcia, Marı́a Angeles</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20000401</creationdate><title>Pharmacokinetics of verapamil in lactating rabbits: Prediction of verapamil distribution into rabbit milk</title><author>Solans, Carlos ; Aramayona, José Javier ; Bregante, Miguel Angel ; Fraile, Lorenzo José ; Rueda, Silvia ; Garcia, Marı́a Angeles</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e291t-5cba76863236ca246fea1a41c17b49aa1ca6a39779ee28feeadb3ec79578344a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Animals</topic><topic>Antiarythmic agents</topic><topic>Binding Sites</topic><topic>Biological and medical sciences</topic><topic>Calcium Channel Blockers - pharmacokinetics</topic><topic>Cardiovascular system</topic><topic>Female</topic><topic>Infusions, Intravenous</topic><topic>Lactation - metabolism</topic><topic>Medical sciences</topic><topic>Milk</topic><topic>Milk - chemistry</topic><topic>Milk composition</topic><topic>Milk-to-blood drug concentration ratio</topic><topic>Pharmacology. Drug treatments</topic><topic>Rabbits</topic><topic>Verapamil</topic><topic>Verapamil - pharmacokinetics</topic><toplevel>online_resources</toplevel><creatorcontrib>Solans, Carlos</creatorcontrib><creatorcontrib>Aramayona, José Javier</creatorcontrib><creatorcontrib>Bregante, Miguel Angel</creatorcontrib><creatorcontrib>Fraile, Lorenzo José</creatorcontrib><creatorcontrib>Rueda, Silvia</creatorcontrib><creatorcontrib>Garcia, Marı́a Angeles</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>General pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Solans, Carlos</au><au>Aramayona, José Javier</au><au>Bregante, Miguel Angel</au><au>Fraile, Lorenzo José</au><au>Rueda, Silvia</au><au>Garcia, Marı́a Angeles</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pharmacokinetics of verapamil in lactating rabbits: Prediction of verapamil distribution into rabbit milk</atitle><jtitle>General pharmacology</jtitle><addtitle>Gen Pharmacol</addtitle><date>2000-04-01</date><risdate>2000</risdate><volume>34</volume><issue>4</issue><spage>237</spage><epage>243</epage><pages>237-243</pages><issn>0306-3623</issn><eissn>1879-0011</eissn><coden>GEPHDP</coden><abstract>In this work, we have studied the pharmacokinetics and milk penetration of verapamil following intravenous administration in lactating rabbits. Milk-to-serum drug concentration ratios (M/B
obs) have been determined using area under the milk and serum concentration–time profiles, and the resulting values have then been compared with those obtained by theoretical classical diffusion milk transfer models that were described by Fleishaker et al. [J. Pharm. Sci. 76 (1987) 189.], Atkinson and Begg [Br. J. Clin. Pharmacol. 25 (1990) 495.], and Stebler and Guentert [Pharm. Res. 9 (1992) 1299.]. The pharmacokinetic profile of verapamil in lactating rabbits following endovenous administration is described in the form of a two-compartment model. Moreover, we detected an important milk transfer after endovenous administration of verapamil in lactating rabbits. M/B
obs was near 15. The classical diffusional models mentioned were not able to predict this extensive transfer of verapamil into rabbit milk. However, when the classical Fleishaker equation was modified and a stepwise regression was carried out, we found that the M/B
obs value could be predicted using the plasma and milk protein binding.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>11282217</pmid><doi>10.1016/S0306-3623(00)00066-5</doi><tpages>7</tpages></addata></record> |
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| ispartof | General pharmacology, 2000-04, Vol.34 (4), p.237-243 |
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| subjects | Animals Antiarythmic agents Binding Sites Biological and medical sciences Calcium Channel Blockers - pharmacokinetics Cardiovascular system Female Infusions, Intravenous Lactation - metabolism Medical sciences Milk Milk - chemistry Milk composition Milk-to-blood drug concentration ratio Pharmacology. Drug treatments Rabbits Verapamil Verapamil - pharmacokinetics |
| title | Pharmacokinetics of verapamil in lactating rabbits: Prediction of verapamil distribution into rabbit milk |
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