Cytokine regulation of apoptosis and Bcl-2 expression in lymphocytes of patients with systemic lupus erythematosus

Both faulty regulation of apoptosis and the inappropriate expression of several interleukins have been considered important defects of lymphocytes in the human autoimmune disease systemic lupus erythematosus (SLE). We therefore tested the in vitro effect of recombinant interleukin (IL-)-2, 4, 7, and...

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Veröffentlicht in:	Cell death and differentiation 2000-10, Vol.7 (10), p.966-972
Hauptverfasser:	Graninger, W B, Steiner, C W, Graninger, M T, Aringer, M, Smolen, J S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Apoptosis Apoptosis - immunology Autoimmune diseases Bcl-2 protein Cell death Cytokines Cytokines - immunology Cytokines - metabolism Female Humans In Situ Nick-End Labeling Interleukin-15 - immunology Interleukin-15 - metabolism Interleukin-2 - immunology Interleukin-2 - metabolism Interleukin-4 - immunology Interleukin-4 - metabolism Interleukin-7 - immunology Interleukin-7 - metabolism Lupus Lupus Erythematosus, Systemic - immunology Lupus Erythematosus, Systemic - metabolism Lymphocytes Lymphocytes - cytology Lymphocytes - immunology Lymphocytes - metabolism Male Middle Aged propidium iodide Proto-Oncogene Proteins c-bcl-2 - biosynthesis Proto-Oncogene Proteins c-bcl-2 - immunology
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