Increase in intracellular calcium induced by stimulating histamine H1 receptors in macrophage-like P388D1 cells
The addition of histamine to macrophage-like P388D1 cells resulted in a dose-dependent increase in intracellular calcium [Ca 2+] i measured by fura-2 in single cells. The maximum level of [Ca 2+] i was obtained by addition of 1×10 −4M histamine. The increase was primarily due to release from the int...
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| Veröffentlicht in: | Biochemical and biophysical research communications 1991-12, Vol.181 (3), p.1156-1163 |
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| container_title | Biochemical and biophysical research communications |
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| creator | Ohno, Shigeru Shirai, Akira Ueda, Atsuhisa Igarashi, Toshihisa Ishigatsubo, Yoshiaki Tani, Kenji Okubo, Takao Hikawa, Naoshi Kawakami, Tadashi Takenaka, Toshifumi |
| description | The addition of histamine to macrophage-like P388D1 cells resulted in a dose-dependent increase in intracellular calcium [Ca
2+]
i measured by fura-2 in single cells. The maximum level of [Ca
2+]
i was obtained by addition of 1×10
−4M histamine. The increase was primarily due to release from the intracellular store. The addition of an H1 specific antagonist pyrilamine before histamine treatment inhibited the increase reversibly, while an H2 specific antagonist cimetidine had no inhibitory effect. Histamine also resulted in a dose-dependent increase in cGMP but not in cAMP. These data suggest the existence of histamine H1 receptors in these cells and histamine may have some biological effect on the function of macrophages via [Ca
2+]
i and cGMP as the second messengers. |
| doi_str_mv | 10.1016/0006-291X(91)92060-W |
| format | Article |
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2+]
i measured by fura-2 in single cells. The maximum level of [Ca
2+]
i was obtained by addition of 1×10
−4M histamine. The increase was primarily due to release from the intracellular store. The addition of an H1 specific antagonist pyrilamine before histamine treatment inhibited the increase reversibly, while an H2 specific antagonist cimetidine had no inhibitory effect. Histamine also resulted in a dose-dependent increase in cGMP but not in cAMP. These data suggest the existence of histamine H1 receptors in these cells and histamine may have some biological effect on the function of macrophages via [Ca
2+]
i and cGMP as the second messengers.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1016/0006-291X(91)92060-W</identifier><identifier>PMID: 1662494</identifier><identifier>CODEN: BBRCA9</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; calcium ; Calcium - metabolism ; Calcium - pharmacology ; Cell Line ; Cell receptors ; Cell structures and functions ; Cyclic AMP - metabolism ; Cyclic GMP - metabolism ; Fundamental and applied biological sciences. Psychology ; Fura-2 ; Histamine - pharmacology ; histamine H1 ; Kinetics ; Leukemia P388 ; Macrophages - drug effects ; Macrophages - physiology ; Microscopy, Fluorescence ; Molecular and cellular biology ; Pyrilamine - pharmacology ; Receptors, Histamine H1 - drug effects ; Receptors, Histamine H1 - physiology</subject><ispartof>Biochemical and biophysical research communications, 1991-12, Vol.181 (3), p.1156-1163</ispartof><rights>1991</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-4659111e3b75316b6da702f2a09dbfa602f9cbcd4ce8923042854e650bc5caff3</citedby><cites>FETCH-LOGICAL-c417t-4659111e3b75316b6da702f2a09dbfa602f9cbcd4ce8923042854e650bc5caff3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0006291X9192060W$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5106234$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1662494$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ohno, Shigeru</creatorcontrib><creatorcontrib>Shirai, Akira</creatorcontrib><creatorcontrib>Ueda, Atsuhisa</creatorcontrib><creatorcontrib>Igarashi, Toshihisa</creatorcontrib><creatorcontrib>Ishigatsubo, Yoshiaki</creatorcontrib><creatorcontrib>Tani, Kenji</creatorcontrib><creatorcontrib>Okubo, Takao</creatorcontrib><creatorcontrib>Hikawa, Naoshi</creatorcontrib><creatorcontrib>Kawakami, Tadashi</creatorcontrib><creatorcontrib>Takenaka, Toshifumi</creatorcontrib><title>Increase in intracellular calcium induced by stimulating histamine H1 receptors in macrophage-like P388D1 cells</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>The addition of histamine to macrophage-like P388D1 cells resulted in a dose-dependent increase in intracellular calcium [Ca
2+]
i measured by fura-2 in single cells. The maximum level of [Ca
2+]
i was obtained by addition of 1×10
−4M histamine. The increase was primarily due to release from the intracellular store. The addition of an H1 specific antagonist pyrilamine before histamine treatment inhibited the increase reversibly, while an H2 specific antagonist cimetidine had no inhibitory effect. Histamine also resulted in a dose-dependent increase in cGMP but not in cAMP. These data suggest the existence of histamine H1 receptors in these cells and histamine may have some biological effect on the function of macrophages via [Ca
2+]
i and cGMP as the second messengers.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>calcium</subject><subject>Calcium - metabolism</subject><subject>Calcium - pharmacology</subject><subject>Cell Line</subject><subject>Cell receptors</subject><subject>Cell structures and functions</subject><subject>Cyclic AMP - metabolism</subject><subject>Cyclic GMP - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fura-2</subject><subject>Histamine - pharmacology</subject><subject>histamine H1</subject><subject>Kinetics</subject><subject>Leukemia P388</subject><subject>Macrophages - drug effects</subject><subject>Macrophages - physiology</subject><subject>Microscopy, Fluorescence</subject><subject>Molecular and cellular biology</subject><subject>Pyrilamine - pharmacology</subject><subject>Receptors, Histamine H1 - drug effects</subject><subject>Receptors, Histamine H1 - physiology</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV1LHTEQhkOp2KPtP2ghF0X0Yu1MNps9uRHEbxDaixZ7F7LZWU3dj2OyK_jvzfYc9E4hkDDzzMvkfRn7inCIgOoHAKhMaPy7r_FAC1CQ3XxgCwQNmUCQH9niBfnEdmL8B4Aold5m26iUkFou2HDVu0A2Evd9OmOwjtp2am3gzrbOT12q1pOjmldPPI6-S73R97f8zsfRdr4nfok8kKPVOIQ4y3TWhWF1Z28pa_098V_5cnmKfBaOn9lWY9tIXzb3Lvtzfvb75DK7_nlxdXJ8nTmJ5ZhJVWhEpLwqixxVpWpbgmiEBV1XjVXprV3lauloqUUOUiwLSaqAyhXONk2-y_bWuqswPEwUR9P5OG9gexqmaEpR6EJD_i6ICkuZl5hAuQbT52IM1JhV8J0NTwbBzIGY2W0zu200mv-BmJs09m2jP1Ud1a9D6wRS__umb2NyvAm2dz6-YAWCEvmMHa0xSqY9egomOk99ysUn70dTD_7tPZ4Bh2qnjA</recordid><startdate>19911231</startdate><enddate>19911231</enddate><creator>Ohno, Shigeru</creator><creator>Shirai, Akira</creator><creator>Ueda, Atsuhisa</creator><creator>Igarashi, Toshihisa</creator><creator>Ishigatsubo, Yoshiaki</creator><creator>Tani, Kenji</creator><creator>Okubo, Takao</creator><creator>Hikawa, Naoshi</creator><creator>Kawakami, Tadashi</creator><creator>Takenaka, Toshifumi</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>8FD</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19911231</creationdate><title>Increase in intracellular calcium induced by stimulating histamine H1 receptors in macrophage-like P388D1 cells</title><author>Ohno, Shigeru ; Shirai, Akira ; Ueda, Atsuhisa ; Igarashi, Toshihisa ; Ishigatsubo, Yoshiaki ; Tani, Kenji ; Okubo, Takao ; Hikawa, Naoshi ; Kawakami, Tadashi ; Takenaka, Toshifumi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-4659111e3b75316b6da702f2a09dbfa602f9cbcd4ce8923042854e650bc5caff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>calcium</topic><topic>Calcium - metabolism</topic><topic>Calcium - pharmacology</topic><topic>Cell Line</topic><topic>Cell receptors</topic><topic>Cell structures and functions</topic><topic>Cyclic AMP - metabolism</topic><topic>Cyclic GMP - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fura-2</topic><topic>Histamine - pharmacology</topic><topic>histamine H1</topic><topic>Kinetics</topic><topic>Leukemia P388</topic><topic>Macrophages - drug effects</topic><topic>Macrophages - physiology</topic><topic>Microscopy, Fluorescence</topic><topic>Molecular and cellular biology</topic><topic>Pyrilamine - pharmacology</topic><topic>Receptors, Histamine H1 - drug effects</topic><topic>Receptors, Histamine H1 - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ohno, Shigeru</creatorcontrib><creatorcontrib>Shirai, Akira</creatorcontrib><creatorcontrib>Ueda, Atsuhisa</creatorcontrib><creatorcontrib>Igarashi, Toshihisa</creatorcontrib><creatorcontrib>Ishigatsubo, Yoshiaki</creatorcontrib><creatorcontrib>Tani, Kenji</creatorcontrib><creatorcontrib>Okubo, Takao</creatorcontrib><creatorcontrib>Hikawa, Naoshi</creatorcontrib><creatorcontrib>Kawakami, Tadashi</creatorcontrib><creatorcontrib>Takenaka, Toshifumi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ohno, Shigeru</au><au>Shirai, Akira</au><au>Ueda, Atsuhisa</au><au>Igarashi, Toshihisa</au><au>Ishigatsubo, Yoshiaki</au><au>Tani, Kenji</au><au>Okubo, Takao</au><au>Hikawa, Naoshi</au><au>Kawakami, Tadashi</au><au>Takenaka, Toshifumi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increase in intracellular calcium induced by stimulating histamine H1 receptors in macrophage-like P388D1 cells</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>1991-12-31</date><risdate>1991</risdate><volume>181</volume><issue>3</issue><spage>1156</spage><epage>1163</epage><pages>1156-1163</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><coden>BBRCA9</coden><abstract>The addition of histamine to macrophage-like P388D1 cells resulted in a dose-dependent increase in intracellular calcium [Ca
2+]
i measured by fura-2 in single cells. The maximum level of [Ca
2+]
i was obtained by addition of 1×10
−4M histamine. The increase was primarily due to release from the intracellular store. The addition of an H1 specific antagonist pyrilamine before histamine treatment inhibited the increase reversibly, while an H2 specific antagonist cimetidine had no inhibitory effect. Histamine also resulted in a dose-dependent increase in cGMP but not in cAMP. These data suggest the existence of histamine H1 receptors in these cells and histamine may have some biological effect on the function of macrophages via [Ca
2+]
i and cGMP as the second messengers.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>1662494</pmid><doi>10.1016/0006-291X(91)92060-W</doi><tpages>8</tpages></addata></record> |
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| ispartof | Biochemical and biophysical research communications, 1991-12, Vol.181 (3), p.1156-1163 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Biological and medical sciences calcium Calcium - metabolism Calcium - pharmacology Cell Line Cell receptors Cell structures and functions Cyclic AMP - metabolism Cyclic GMP - metabolism Fundamental and applied biological sciences. Psychology Fura-2 Histamine - pharmacology histamine H1 Kinetics Leukemia P388 Macrophages - drug effects Macrophages - physiology Microscopy, Fluorescence Molecular and cellular biology Pyrilamine - pharmacology Receptors, Histamine H1 - drug effects Receptors, Histamine H1 - physiology |
| title | Increase in intracellular calcium induced by stimulating histamine H1 receptors in macrophage-like P388D1 cells |
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