Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo

The naïve and memory T lymphocyte pools are maintained through poorly understood homeostatic mechanisms that may include signaling via cytokine receptors. We show that interleukin-7 (IL-7) plays multiple roles in regulating homeostasis of CD8 + T cells. We found that IL-7 was required for homeostati...

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Veröffentlicht in:	Nature immunology 2000-11, Vol.1 (5), p.426-432
Hauptverfasser:	Lefrançois, Leo, Schluns, Kimberly S, Kieper, William C, Jameson, Stephen C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive Transfer Animals Biomedical and Life Sciences Biomedicine CD8-Positive T-Lymphocytes - cytology CD8-Positive T-Lymphocytes - immunology Cell Division Cell Line Homeostasis Immunologic Memory Immunology Infectious Diseases Interleukin-7 Interleukin-7 - genetics Interleukin-7 - immunology Lymphocyte Activation Lymphocytes Major histocompatibility complex Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Physiological aspects Proto-Oncogene Proteins c-bcl-2 - metabolism Radiation Tolerance - immunology Receptors, Interleukin-7 - genetics Receptors, Interleukin-7 - metabolism T cells
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