Calcium channel antagonists for the treatment of bipolar disorder
Calcium channel antagonists (CCAs) have many clinical applications, including their possible use in the treatment of bipolar disorder. Two justifications for this last application are some overlap in physiological activities of CCAs with those of lithium, and a possible association between bipolar d...
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| Veröffentlicht in: | Bipolar disorders 2000-06, Vol.2 (2), p.108-119 |
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| container_title | Bipolar disorders |
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| creator | Levy, Naomi A Janicak, Philip G |
| description | Calcium channel antagonists (CCAs) have many clinical applications, including their possible use in the treatment of bipolar disorder. Two justifications for this last application are some overlap in physiological activities of CCAs with those of lithium, and a possible association between bipolar disorder and calcium dysregulation. While the data from earlier studies support the use of verapamil in treating bipolar mania, more recent better‐controlled trials have not. This paper reviews the available body of data regarding CCAs in the treatment of bipolar disorder, concluding there is presently limited support for their efficacy. |
| doi_str_mv | 10.1034/j.1399-5618.2000.020204.x |
| format | Article |
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| ispartof | Bipolar disorders, 2000-06, Vol.2 (2), p.108-119 |
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| language | eng |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Antimanic Agents - therapeutic use bipolar disorder Bipolar Disorder - drug therapy Bipolar Disorder - metabolism calcium channel antagonists Calcium Channel Blockers - pharmacology Calcium Channel Blockers - therapeutic use Diltiazem - therapeutic use Double-Blind Method Drug Therapy, Combination Humans Lithium Compounds - therapeutic use Nifedipine - therapeutic use Nimodipine - therapeutic use Randomized Controlled Trials as Topic treatment Verapamil - therapeutic use |
| title | Calcium channel antagonists for the treatment of bipolar disorder |
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