Antitumor effects of the combination therapy with TNF-alpha gene-modified tumor cells and interleukin 12 in a melanoma model in mice

In the present study, TNF-alpha gene-transduced B78 melanoma cells (B78/TNF) were used as a vaccine and combined with interleukin (IL)-12 in the treatment of B78 melanoma-bearing mice. The combined administration of genetically modified melanoma cells and IL-12 induced specific protective antitumor...

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Veröffentlicht in:	Cancer gene therapy 2000-12, Vol.7 (12), p.1581-1590
Hauptverfasser:	Lasek, W, Mackiewicz, A, Czajka, A, Switaj, T, Goł b, J, Wiznerowicz, M, Korczak-Kowalska, G, Bakowiec-Iskra, E Z, Gryska, K, Izycki, D, Jakóbisiak, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antitumor activity CD4 antigen CD8 antigen CD80 antigen Combined vaccines Cytokines Cytotoxicity Drug Therapy, Combination Flow Cytometry g-Interferon Gene therapy Genetic Therapy - methods Humans Immunity, Cellular - immunology Interferon-gamma - blood Interleukin 12 Interleukin-12 - genetics Lymphocytes Major histocompatibility complex Major Histocompatibility Complex - immunology Major Histocompatibility Complex - physiology Melanoma Melanoma, Experimental - genetics Melanoma, Experimental - metabolism Melanoma, Experimental - therapy Mice Mice, Inbred C57BL Mice, Inbred DBA Monoclonal antibodies Retroviridae - genetics Spleen - immunology Tetrazolium Salts - metabolism Thiazoles - metabolism Tumor cells Tumor Necrosis Factor-alpha - genetics Tumor necrosis factor-α Vaccines γ-Interferon
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