Accessory factors in clathrin-dependent synaptic vesicle endocytosis

Clathrin-mediated endocytosis is a special form of vesicle budding important for the internalization of receptors and extracellular ligands, for the recycling of plasma membrane components, and for the retrieval of surface proteins destined for degradation. In nerve terminals, clathrin-mediated endo...

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Veröffentlicht in:Nature reviews. Neuroscience 2000-12, Vol.1 (3), p.161-172
Hauptverfasser: De Camilli, Pietro, Slepnev, Vladimir I
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description Clathrin-mediated endocytosis is a special form of vesicle budding important for the internalization of receptors and extracellular ligands, for the recycling of plasma membrane components, and for the retrieval of surface proteins destined for degradation. In nerve terminals, clathrin-mediated endocytosis is crucial for synaptic vesicle recycling. Recent structural studies have provided molecular details of coat assembly. In addition, biochemical and genetic studies have identified numerous accessory proteins that assist the clathrin coat in its function at synapses and in other systems. This review summarizes these advances with a special focus on accessory factors and highlights new aspects of clathrin-mediated endocytosis revealed by the study of these factors.
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subjects Adaptor Protein Complex alpha Subunits
Adaptor Proteins, Vesicular Transport
Animals
Clathrin - physiology
Endocytosis - physiology
Humans
Membrane Proteins - physiology
Proteins
Synaptic Vesicles - physiology
Synaptic Vesicles - ultrastructure
title Accessory factors in clathrin-dependent synaptic vesicle endocytosis
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