Human embryonic cytochrome p450s: Phenoxazone ethers as probes for expression of functional isoforms during organogenesis

Human embryonic tissues were investigated during the period of organogenesis with a combination of substrate probes, selective inhibitors and immunoprobes in terms of their capacity to express functional P450 isoforms. A series of phenoxazone ethers utilized as substrate probes revealed that human e...

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Veröffentlicht in:	Biochemical pharmacology 1991-11, Vol.42 (12), p.2377-2385
Hauptverfasser:	Lee, Qwihee P., Fantel, Alan G., Juchau, Mont R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Antibodies, Monoclonal Benzoflavones - pharmacology Biological and medical sciences Biotransformation Carbon Monoxide - pharmacology Cytochrome P-450 CYP2B1 Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Enzyme System - immunology Cytochrome P-450 Enzyme System - metabolism Embryo, Mammalian - drug effects Embryo, Mammalian - enzymology Enzymes and enzyme inhibitors Ethers - pharmacology Fundamental and applied biological sciences. Psychology Humans Isoenzymes - immunology Isoenzymes - metabolism Metyrapone - pharmacology Morphogenesis - drug effects Orphenadrine - pharmacology Oxazines - pharmacology Oxidoreductases Oxidoreductases - antagonists & inhibitors Xenobiotics - pharmacology
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