Markers of enteric inflammation in enteroaggregative Escherichia coli diarrhea in travelers
As part of a traveler's diarrhea study carried out in Guadalajara, Mexico, and Goa, India, we conducted a case control study to evaluate fecal markers of enteric inflammation in three groups. Forty-five cases of enteroaggregative Escherichia coli (EAEC) diarrhea were compared to 56 controls wit...
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| Veröffentlicht in: | The American journal of tropical medicine and hygiene 2000-06, Vol.62 (6), p.711-713 |
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| container_title | The American journal of tropical medicine and hygiene |
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| creator | Bouckenooghe, AR Dupont, HL Jiang, ZD Adachi, J Mathewson, JJ Verenkar, MP Rodrigues, S Steffen, R |
| description | As part of a traveler's diarrhea study carried out in Guadalajara, Mexico, and Goa, India, we conducted a case control study to evaluate fecal markers of enteric inflammation in three groups. Forty-five cases of enteroaggregative Escherichia coli (EAEC) diarrhea were compared to 56 controls with enterotoxigenic E. coli (ETEC) diarrhea, and 126 controls with diarrhea without identifiable pathogens. For EAEC cases we found fecal leukocytes, occult blood, and lactoferrin in 13 (28.9%), 14 (31.1%), and 27 (60.0%) patients, respectively; for ETEC controls they were 15 (26.8%), 16 (28.6%), and 15 (26.8%) respectively; and for patients without identifiable pathogens 19 (15.1%), 34 (27.0%) and 27 (21.4%) were seen for the presence of a positive fecal lactoferrin test in EAEC cases was statistically significant compared to both control groups. The study provides evidence that EAEC infection is associated with an intestinal inflammatory response. |
| doi_str_mv | 10.4269/ajtmh.2000.62.711 |
| format | Article |
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Forty-five cases of enteroaggregative Escherichia coli (EAEC) diarrhea were compared to 56 controls with enterotoxigenic E. coli (ETEC) diarrhea, and 126 controls with diarrhea without identifiable pathogens. For EAEC cases we found fecal leukocytes, occult blood, and lactoferrin in 13 (28.9%), 14 (31.1%), and 27 (60.0%) patients, respectively; for ETEC controls they were 15 (26.8%), 16 (28.6%), and 15 (26.8%) respectively; and for patients without identifiable pathogens 19 (15.1%), 34 (27.0%) and 27 (21.4%) were seen for the presence of a positive fecal lactoferrin test in EAEC cases was statistically significant compared to both control groups. The study provides evidence that EAEC infection is associated with an intestinal inflammatory response.</description><identifier>ISSN: 0002-9637</identifier><identifier>EISSN: 1476-1645</identifier><identifier>DOI: 10.4269/ajtmh.2000.62.711</identifier><identifier>PMID: 11304060</identifier><identifier>CODEN: AJTHAB</identifier><language>eng</language><publisher>Lawrence, KS: ASTMH</publisher><subject>Adolescent ; Adult ; Bacterial Adhesion ; Bacterial diseases ; Bacterial diseases of the digestive system and abdomen ; Biological and medical sciences ; Biomarkers ; Case-Control Studies ; Cell Line ; Diarrhea - microbiology ; Enteritis - microbiology ; Enteritis - pathology ; Escherichia coli ; Escherichia coli - physiology ; Escherichia coli Infections - microbiology ; Escherichia coli Infections - pathology ; Feces - chemistry ; Feces - cytology ; Human bacterial diseases ; Humans ; Infectious diseases ; Lactoferrin - analysis ; Leukocytes - immunology ; Medical sciences ; Occult Blood ; Travel ; Tropical medicine</subject><ispartof>The American journal of tropical medicine and hygiene, 2000-06, Vol.62 (6), p.711-713</ispartof><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c430t-3ffc53c1f642b5aa654ec91f1839b746d4456f2a7ee24019ef0820e1204185973</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1023491$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11304060$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bouckenooghe, AR</creatorcontrib><creatorcontrib>Dupont, HL</creatorcontrib><creatorcontrib>Jiang, ZD</creatorcontrib><creatorcontrib>Adachi, J</creatorcontrib><creatorcontrib>Mathewson, JJ</creatorcontrib><creatorcontrib>Verenkar, MP</creatorcontrib><creatorcontrib>Rodrigues, S</creatorcontrib><creatorcontrib>Steffen, R</creatorcontrib><title>Markers of enteric inflammation in enteroaggregative Escherichia coli diarrhea in travelers</title><title>The American journal of tropical medicine and hygiene</title><addtitle>Am J Trop Med Hyg</addtitle><description>As part of a traveler's diarrhea study carried out in Guadalajara, Mexico, and Goa, India, we conducted a case control study to evaluate fecal markers of enteric inflammation in three groups. Forty-five cases of enteroaggregative Escherichia coli (EAEC) diarrhea were compared to 56 controls with enterotoxigenic E. coli (ETEC) diarrhea, and 126 controls with diarrhea without identifiable pathogens. For EAEC cases we found fecal leukocytes, occult blood, and lactoferrin in 13 (28.9%), 14 (31.1%), and 27 (60.0%) patients, respectively; for ETEC controls they were 15 (26.8%), 16 (28.6%), and 15 (26.8%) respectively; and for patients without identifiable pathogens 19 (15.1%), 34 (27.0%) and 27 (21.4%) were seen for the presence of a positive fecal lactoferrin test in EAEC cases was statistically significant compared to both control groups. The study provides evidence that EAEC infection is associated with an intestinal inflammatory response.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Bacterial Adhesion</subject><subject>Bacterial diseases</subject><subject>Bacterial diseases of the digestive system and abdomen</subject><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>Case-Control Studies</subject><subject>Cell Line</subject><subject>Diarrhea - microbiology</subject><subject>Enteritis - microbiology</subject><subject>Enteritis - pathology</subject><subject>Escherichia coli</subject><subject>Escherichia coli - physiology</subject><subject>Escherichia coli Infections - microbiology</subject><subject>Escherichia coli Infections - pathology</subject><subject>Feces - chemistry</subject><subject>Feces - cytology</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Lactoferrin - analysis</subject><subject>Leukocytes - immunology</subject><subject>Medical sciences</subject><subject>Occult Blood</subject><subject>Travel</subject><subject>Tropical medicine</subject><issn>0002-9637</issn><issn>1476-1645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1v1DAQhi1ERZfCD-CCcgBuWTy2YydHVJUPqaiXcuJgzXrHGxcnKXa2K_59ne5KcOQ0mplnnpFext4AXyuhu494Nw_9WnDO11qsDcAztgJldA1aNc_ZqixE3WlpztnLnO84h1YAvGDnAJIrrvmK_fyO6RelXE2-onGmFFwVRh9xGHAO01ia43zC3S7RrgwfqLrKrl_QPmDlphiqbcCUesIFnxM-UCzOV-zMY8z0-lQv2I_PV7eXX-vrmy_fLj9d105JPtfSe9dIB14rsWkQdaPIdeChld3GKL1VqtFeoCESikNHnreCEwiuoG06Iy_Yh6P3Pk2_95RnO4TsKEYcadpna0TTSvMfILTcGMV5AeEIujTlnMjb-xQGTH8scLtEb5-it0v0Vgtboi83b0_y_Wag7d-LU9YFeHcCMDuMPuHoQv7HLKTqFs_7I9aHXX8IiWweMMZiBXs4HMo3_fTvER30mg0</recordid><startdate>20000601</startdate><enddate>20000601</enddate><creator>Bouckenooghe, AR</creator><creator>Dupont, HL</creator><creator>Jiang, ZD</creator><creator>Adachi, J</creator><creator>Mathewson, JJ</creator><creator>Verenkar, MP</creator><creator>Rodrigues, S</creator><creator>Steffen, R</creator><general>ASTMH</general><general>Allen Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>20000601</creationdate><title>Markers of enteric inflammation in enteroaggregative Escherichia coli diarrhea in travelers</title><author>Bouckenooghe, AR ; 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| subjects | Adolescent Adult Bacterial Adhesion Bacterial diseases Bacterial diseases of the digestive system and abdomen Biological and medical sciences Biomarkers Case-Control Studies Cell Line Diarrhea - microbiology Enteritis - microbiology Enteritis - pathology Escherichia coli Escherichia coli - physiology Escherichia coli Infections - microbiology Escherichia coli Infections - pathology Feces - chemistry Feces - cytology Human bacterial diseases Humans Infectious diseases Lactoferrin - analysis Leukocytes - immunology Medical sciences Occult Blood Travel Tropical medicine |
| title | Markers of enteric inflammation in enteroaggregative Escherichia coli diarrhea in travelers |
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