T-lymphocyte subsets in nephrotic syndrome
T-lymphocyte subsets in nephrotic syndrome. T-lymphocyte subsets when measured in steroid responsive nephrotic syndrome (SRNS) have demonstrated significant variance from normal values T-cell subsets were studied by using two-color flow cytometric analysis in 32 children (9.2 ± 5 years of age) with...
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| Veröffentlicht in: | Kidney international 1991-11, Vol.40 (5), p.913-916 |
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| container_title | Kidney international |
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| creator | Fiser, Richard T. Arnold, Watson C. Charlton, Ronald K. Steele, Russell W. Childress, Sherri H. Shirkey, Belinda |
| description | T-lymphocyte subsets in nephrotic syndrome. T-lymphocyte subsets when measured in steroid responsive nephrotic syndrome (SRNS) have demonstrated significant variance from normal values T-cell subsets were studied by using two-color flow cytometric analysis in 32 children (9.2 ± 5 years of age) with SRNS. The children were divided into four groups: a) SRNS in acute relapse, on prednisone; b) SRNS in acute relapse, off prednisone; c) SRNS in long-term remission, off prednisone (nephrotic controls); d) patients in remission on long-term prednisone therapy; and e) 15 age-matched normal controls. Children suffering an acute relapse of SRNS showed an increase in Leu2a+/DR+ (CD8) activated lymphocytes (P < 0.05), a decrease in Leu4a+ total T-lymphocytes (P = 0.01) and a decrease in Leu3a+ (CD4) helper T-cells (P < 0.05) when compared to normal controls and nephrotic controls. Though some subset changes may represent a prednisone effect and the functional role of these lymphocytes in the disease process is unknown, this study provides additional evidence to support a role for abnormal T-cell subsets in the etiology of SRNS. |
| doi_str_mv | 10.1038/ki.1991.293 |
| format | Article |
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T-lymphocyte subsets when measured in steroid responsive nephrotic syndrome (SRNS) have demonstrated significant variance from normal values T-cell subsets were studied by using two-color flow cytometric analysis in 32 children (9.2 ± 5 years of age) with SRNS. The children were divided into four groups: a) SRNS in acute relapse, on prednisone; b) SRNS in acute relapse, off prednisone; c) SRNS in long-term remission, off prednisone (nephrotic controls); d) patients in remission on long-term prednisone therapy; and e) 15 age-matched normal controls. Children suffering an acute relapse of SRNS showed an increase in Leu2a+/DR+ (CD8) activated lymphocytes (P < 0.05), a decrease in Leu4a+ total T-lymphocytes (P = 0.01) and a decrease in Leu3a+ (CD4) helper T-cells (P < 0.05) when compared to normal controls and nephrotic controls. Though some subset changes may represent a prednisone effect and the functional role of these lymphocytes in the disease process is unknown, this study provides additional evidence to support a role for abnormal T-cell subsets in the etiology of SRNS.</description><identifier>ISSN: 0085-2538</identifier><identifier>EISSN: 1523-1755</identifier><identifier>DOI: 10.1038/ki.1991.293</identifier><identifier>PMID: 1762295</identifier><identifier>CODEN: KDYIA5</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adolescent ; Antigens, Differentiation ; Biological and medical sciences ; Child ; Child, Preschool ; Female ; Flow Cytometry ; HLA-DR Antigens ; Humans ; Immunomodulators ; Infant ; Lymphocyte Activation ; Male ; Medical sciences ; Nephrotic Syndrome - immunology ; Pharmacology. 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T-lymphocyte subsets when measured in steroid responsive nephrotic syndrome (SRNS) have demonstrated significant variance from normal values T-cell subsets were studied by using two-color flow cytometric analysis in 32 children (9.2 ± 5 years of age) with SRNS. The children were divided into four groups: a) SRNS in acute relapse, on prednisone; b) SRNS in acute relapse, off prednisone; c) SRNS in long-term remission, off prednisone (nephrotic controls); d) patients in remission on long-term prednisone therapy; and e) 15 age-matched normal controls. Children suffering an acute relapse of SRNS showed an increase in Leu2a+/DR+ (CD8) activated lymphocytes (P < 0.05), a decrease in Leu4a+ total T-lymphocytes (P = 0.01) and a decrease in Leu3a+ (CD4) helper T-cells (P < 0.05) when compared to normal controls and nephrotic controls. Though some subset changes may represent a prednisone effect and the functional role of these lymphocytes in the disease process is unknown, this study provides additional evidence to support a role for abnormal T-cell subsets in the etiology of SRNS.</description><subject>Adolescent</subject><subject>Antigens, Differentiation</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>Flow Cytometry</subject><subject>HLA-DR Antigens</subject><subject>Humans</subject><subject>Immunomodulators</subject><subject>Infant</subject><subject>Lymphocyte Activation</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nephrotic Syndrome - immunology</subject><subject>Pharmacology. Drug treatments</subject><subject>T-Lymphocyte Subsets - immunology</subject><issn>0085-2538</issn><issn>1523-1755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkEtLxDAURoMo4zi6ci3OQlwoHfNo2mQpgy8YcDOuQ5reMnH6MmmF_ntTOujGRQjhO_nu5SB0SfCKYCYe9nZFpCQrKtkRmhNOWURSzo_RHGPBI8qZOEVn3n_i8JYMz9CMpAmlks_R3TYqh6rdNWboYOn7zEPnl7Ze1tDuXNNZs_RDnbumgnN0UujSw8XhXqCP56ft-jXavL-8rR83kWGMsyiVhiQpKRJTmJymwLmGJCloLA2LhZBFnDPKiMxIWE4wkInhJBVxnPFwtGALdDv1tq756sF3qrLeQFnqGpreq5SGbymWAbyfQOMa7x0UqnW20m5QBKvRjNpbNZpRwUygrw61fVZB_sdOKkJ-c8i1N7osnK6N9b8YjwVLxFhzPWG17noHv_nejpOmQXwiIEj6tuCUNxZqA7l1YDqVN_bfBX8ABzyFoA</recordid><startdate>199111</startdate><enddate>199111</enddate><creator>Fiser, Richard T.</creator><creator>Arnold, Watson C.</creator><creator>Charlton, Ronald K.</creator><creator>Steele, Russell W.</creator><creator>Childress, Sherri H.</creator><creator>Shirkey, Belinda</creator><general>Elsevier Inc</general><general>Nature Publishing</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199111</creationdate><title>T-lymphocyte subsets in nephrotic syndrome</title><author>Fiser, Richard T. ; Arnold, Watson C. ; Charlton, Ronald K. ; Steele, Russell W. ; Childress, Sherri H. ; Shirkey, Belinda</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3353-79c1671f6cfcd27e55ae66f249c34889f4d32319b108583e96c517844b544ba83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Adolescent</topic><topic>Antigens, Differentiation</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>Flow Cytometry</topic><topic>HLA-DR Antigens</topic><topic>Humans</topic><topic>Immunomodulators</topic><topic>Infant</topic><topic>Lymphocyte Activation</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nephrotic Syndrome - immunology</topic><topic>Pharmacology. Drug treatments</topic><topic>T-Lymphocyte Subsets - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fiser, Richard T.</creatorcontrib><creatorcontrib>Arnold, Watson C.</creatorcontrib><creatorcontrib>Charlton, Ronald K.</creatorcontrib><creatorcontrib>Steele, Russell W.</creatorcontrib><creatorcontrib>Childress, Sherri H.</creatorcontrib><creatorcontrib>Shirkey, Belinda</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Kidney international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fiser, Richard T.</au><au>Arnold, Watson C.</au><au>Charlton, Ronald K.</au><au>Steele, Russell W.</au><au>Childress, Sherri H.</au><au>Shirkey, Belinda</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>T-lymphocyte subsets in nephrotic syndrome</atitle><jtitle>Kidney international</jtitle><addtitle>Kidney Int</addtitle><date>1991-11</date><risdate>1991</risdate><volume>40</volume><issue>5</issue><spage>913</spage><epage>916</epage><pages>913-916</pages><issn>0085-2538</issn><eissn>1523-1755</eissn><coden>KDYIA5</coden><abstract>T-lymphocyte subsets in nephrotic syndrome. T-lymphocyte subsets when measured in steroid responsive nephrotic syndrome (SRNS) have demonstrated significant variance from normal values T-cell subsets were studied by using two-color flow cytometric analysis in 32 children (9.2 ± 5 years of age) with SRNS. The children were divided into four groups: a) SRNS in acute relapse, on prednisone; b) SRNS in acute relapse, off prednisone; c) SRNS in long-term remission, off prednisone (nephrotic controls); d) patients in remission on long-term prednisone therapy; and e) 15 age-matched normal controls. Children suffering an acute relapse of SRNS showed an increase in Leu2a+/DR+ (CD8) activated lymphocytes (P < 0.05), a decrease in Leu4a+ total T-lymphocytes (P = 0.01) and a decrease in Leu3a+ (CD4) helper T-cells (P < 0.05) when compared to normal controls and nephrotic controls. Though some subset changes may represent a prednisone effect and the functional role of these lymphocytes in the disease process is unknown, this study provides additional evidence to support a role for abnormal T-cell subsets in the etiology of SRNS.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>1762295</pmid><doi>10.1038/ki.1991.293</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Antigens, Differentiation Biological and medical sciences Child Child, Preschool Female Flow Cytometry HLA-DR Antigens Humans Immunomodulators Infant Lymphocyte Activation Male Medical sciences Nephrotic Syndrome - immunology Pharmacology. Drug treatments T-Lymphocyte Subsets - immunology |
| title | T-lymphocyte subsets in nephrotic syndrome |
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