The antinociception evoked by anterior pretectal nucleus stimulation is partially dependent upon ventrolateral medullary neurones
Electrical stimulation (35 μA rms/15 s) of the anterior pretectal nucleus (APtN) inhibits the spinal reflex of the tail-flick (TF) to noxious heat in unanaesthetised rats. APtN stimulation also reduces the nociceptive response of spinal dorsal horn neurones in halothane-anaesthetised rats. This stud...
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| Veröffentlicht in: | Pain (Amsterdam) 1991-11, Vol.47 (2), p.231-239 |
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| creator | Terenzi, M.G. Rees, H. Morgan, S.J.S. Foster, G.A. Roberts, M.H.T. |
| description | Electrical stimulation (35 μA rms/15 s) of the anterior pretectal nucleus (APtN) inhibits the spinal reflex of the tail-flick (TF) to noxious heat in unanaesthetised rats. APtN stimulation also reduces the nociceptive response of spinal dorsal horn neurones in halothane-anaesthetised rats. This study determined if the antinociceptive effects of APtN stimulation depended on neurones in the ventral medulla. Bilateral electrolytic lesions of the ventrolateral medulla, but not the nucleus raphe magnus, reduced by 70% the antinociceptive effect of APtN stimulation in the TF test. In rats anaesthetised with halothane, electrical stimulation of the APtN (single square wave 0.1 msec pulses, 2–20 μA, 1 Hz) excited cells in the ventrolateral medulla. These data suggest a connection between both areas. This connection is futher confirmed by neuroanatomical tract tracing studies in which the retrograde dye Fast Blue was injected into the ventrolateral medulla. Fluorescent cell bodies were found in the APtN. We therefore conclude that the ventrolateral medulla is part of a descending antinociceptive pathway from the APtN. |
| doi_str_mv | 10.1016/0304-3959(91)90209-G |
| format | Article |
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APtN stimulation also reduces the nociceptive response of spinal dorsal horn neurones in halothane-anaesthetised rats. This study determined if the antinociceptive effects of APtN stimulation depended on neurones in the ventral medulla. Bilateral electrolytic lesions of the ventrolateral medulla, but not the nucleus raphe magnus, reduced by 70% the antinociceptive effect of APtN stimulation in the TF test. In rats anaesthetised with halothane, electrical stimulation of the APtN (single square wave 0.1 msec pulses, 2–20 μA, 1 Hz) excited cells in the ventrolateral medulla. These data suggest a connection between both areas. This connection is futher confirmed by neuroanatomical tract tracing studies in which the retrograde dye Fast Blue was injected into the ventrolateral medulla. Fluorescent cell bodies were found in the APtN. We therefore conclude that the ventrolateral medulla is part of a descending antinociceptive pathway from the APtN.</description><identifier>ISSN: 0304-3959</identifier><identifier>EISSN: 1872-6623</identifier><identifier>DOI: 10.1016/0304-3959(91)90209-G</identifier><identifier>PMID: 1762819</identifier><identifier>CODEN: PAINDB</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Animals ; Anterior pretectal nucleus ; Behavior, Animal - physiology ; Biological and medical sciences ; Electric Stimulation ; Fundamental and applied biological sciences. Psychology ; Male ; Medulla Oblongata - physiology ; Mesencephalon - physiology ; Neurons - physiology ; Nucleus paragigantocellularis lateralis ; Pain - physiopathology ; Rats ; Rats, Inbred Strains ; Reaction Time ; Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors ; Spinal Cord - physiology ; Vertebrates: nervous system and sense organs</subject><ispartof>Pain (Amsterdam), 1991-11, Vol.47 (2), p.231-239</ispartof><rights>1991</rights><rights>Lippincott-Raven Publishers.Copyright © Lippincott-Raven Publishers.</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3466-47a56d77212223558a210690470cce386f38c72b28fbce988c769eb8e4b132cf3</citedby><cites>FETCH-LOGICAL-c3466-47a56d77212223558a210690470cce386f38c72b28fbce988c769eb8e4b132cf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0304-3959(91)90209-G$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5150008$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1762819$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Terenzi, M.G.</creatorcontrib><creatorcontrib>Rees, H.</creatorcontrib><creatorcontrib>Morgan, S.J.S.</creatorcontrib><creatorcontrib>Foster, G.A.</creatorcontrib><creatorcontrib>Roberts, M.H.T.</creatorcontrib><title>The antinociception evoked by anterior pretectal nucleus stimulation is partially dependent upon ventrolateral medullary neurones</title><title>Pain (Amsterdam)</title><addtitle>Pain</addtitle><description>Electrical stimulation (35 μA rms/15 s) of the anterior pretectal nucleus (APtN) inhibits the spinal reflex of the tail-flick (TF) to noxious heat in unanaesthetised rats. APtN stimulation also reduces the nociceptive response of spinal dorsal horn neurones in halothane-anaesthetised rats. This study determined if the antinociceptive effects of APtN stimulation depended on neurones in the ventral medulla. Bilateral electrolytic lesions of the ventrolateral medulla, but not the nucleus raphe magnus, reduced by 70% the antinociceptive effect of APtN stimulation in the TF test. In rats anaesthetised with halothane, electrical stimulation of the APtN (single square wave 0.1 msec pulses, 2–20 μA, 1 Hz) excited cells in the ventrolateral medulla. These data suggest a connection between both areas. This connection is futher confirmed by neuroanatomical tract tracing studies in which the retrograde dye Fast Blue was injected into the ventrolateral medulla. Fluorescent cell bodies were found in the APtN. We therefore conclude that the ventrolateral medulla is part of a descending antinociceptive pathway from the APtN.</description><subject>Animals</subject><subject>Anterior pretectal nucleus</subject><subject>Behavior, Animal - physiology</subject><subject>Biological and medical sciences</subject><subject>Electric Stimulation</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Male</subject><subject>Medulla Oblongata - physiology</subject><subject>Mesencephalon - physiology</subject><subject>Neurons - physiology</subject><subject>Nucleus paragigantocellularis lateralis</subject><subject>Pain - physiopathology</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Reaction Time</subject><subject>Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors</subject><subject>Spinal Cord - physiology</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0304-3959</issn><issn>1872-6623</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UU1v1DAQtRBVWQr_ACQfUAWHgD8SJ74goQqWSpW4lLPlOBOtqdcOdrLVHvnnne2u2hsHyx6998Zv3hDyjrPPnHH1hUlWV1I3-qPmnzQTTFfrF2TFu1ZUSgn5kqyeKK_I61L-MMaEEPqcnPNWiY7rFfl3uwFq4-xjct7BNPsUKezSHQy03x8QyD5lOmWYwc020Li4AEuhZfbbJdhHgS90snn2NoQ9HWCCOECc6TIhtsNXTkiEjOotDEsINu9phCWnCOUNORttKPD2dF-Q3z--3179rG5-ra-vvt1UTtZKVXVrGzW0reA4gmyazgrOlGZ1y5wD2alRdq4VvejG3oHusFAa-g7qnkvhRnlBLo99p5z-LlBms_XFAZqJkJZiWtF0kiuGxPpIdDmVkmE0U_ZbtGw4M4fkzSFWc4jVaG4ekzdrlL0_9V96nPJZdIwa8Q8n3BZnw5htdL480Rre4Hq659_vU8DIyl1Y7iGbDdgwbwxSmJJaVVxrzjlWFR6uUPb1KAOMcOdRUZyH6GDwGfdmhuT_b_8BPU-x9g</recordid><startdate>19911101</startdate><enddate>19911101</enddate><creator>Terenzi, M.G.</creator><creator>Rees, H.</creator><creator>Morgan, S.J.S.</creator><creator>Foster, G.A.</creator><creator>Roberts, M.H.T.</creator><general>Elsevier B.V</general><general>Lippincott-Raven Publishers.Copyright Lippincott-Raven Publishers</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19911101</creationdate><title>The antinociception evoked by anterior pretectal nucleus stimulation is partially dependent upon ventrolateral medullary neurones</title><author>Terenzi, M.G. ; Rees, H. ; Morgan, S.J.S. ; Foster, G.A. ; Roberts, M.H.T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3466-47a56d77212223558a210690470cce386f38c72b28fbce988c769eb8e4b132cf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Animals</topic><topic>Anterior pretectal nucleus</topic><topic>Behavior, Animal - physiology</topic><topic>Biological and medical sciences</topic><topic>Electric Stimulation</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Male</topic><topic>Medulla Oblongata - physiology</topic><topic>Mesencephalon - physiology</topic><topic>Neurons - physiology</topic><topic>Nucleus paragigantocellularis lateralis</topic><topic>Pain - physiopathology</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Reaction Time</topic><topic>Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors</topic><topic>Spinal Cord - physiology</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Terenzi, M.G.</creatorcontrib><creatorcontrib>Rees, H.</creatorcontrib><creatorcontrib>Morgan, S.J.S.</creatorcontrib><creatorcontrib>Foster, G.A.</creatorcontrib><creatorcontrib>Roberts, M.H.T.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pain (Amsterdam)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Terenzi, M.G.</au><au>Rees, H.</au><au>Morgan, S.J.S.</au><au>Foster, G.A.</au><au>Roberts, M.H.T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The antinociception evoked by anterior pretectal nucleus stimulation is partially dependent upon ventrolateral medullary neurones</atitle><jtitle>Pain (Amsterdam)</jtitle><addtitle>Pain</addtitle><date>1991-11-01</date><risdate>1991</risdate><volume>47</volume><issue>2</issue><spage>231</spage><epage>239</epage><pages>231-239</pages><issn>0304-3959</issn><eissn>1872-6623</eissn><coden>PAINDB</coden><abstract>Electrical stimulation (35 μA rms/15 s) of the anterior pretectal nucleus (APtN) inhibits the spinal reflex of the tail-flick (TF) to noxious heat in unanaesthetised rats. APtN stimulation also reduces the nociceptive response of spinal dorsal horn neurones in halothane-anaesthetised rats. This study determined if the antinociceptive effects of APtN stimulation depended on neurones in the ventral medulla. Bilateral electrolytic lesions of the ventrolateral medulla, but not the nucleus raphe magnus, reduced by 70% the antinociceptive effect of APtN stimulation in the TF test. In rats anaesthetised with halothane, electrical stimulation of the APtN (single square wave 0.1 msec pulses, 2–20 μA, 1 Hz) excited cells in the ventrolateral medulla. These data suggest a connection between both areas. This connection is futher confirmed by neuroanatomical tract tracing studies in which the retrograde dye Fast Blue was injected into the ventrolateral medulla. Fluorescent cell bodies were found in the APtN. We therefore conclude that the ventrolateral medulla is part of a descending antinociceptive pathway from the APtN.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>1762819</pmid><doi>10.1016/0304-3959(91)90209-G</doi><tpages>9</tpages></addata></record> |
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| ispartof | Pain (Amsterdam), 1991-11, Vol.47 (2), p.231-239 |
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| subjects | Animals Anterior pretectal nucleus Behavior, Animal - physiology Biological and medical sciences Electric Stimulation Fundamental and applied biological sciences. Psychology Male Medulla Oblongata - physiology Mesencephalon - physiology Neurons - physiology Nucleus paragigantocellularis lateralis Pain - physiopathology Rats Rats, Inbred Strains Reaction Time Somesthesis and somesthetic pathways (proprioception, exteroception, nociception) interoception electrolocation. Sensory receptors Spinal Cord - physiology Vertebrates: nervous system and sense organs |
| title | The antinociception evoked by anterior pretectal nucleus stimulation is partially dependent upon ventrolateral medullary neurones |
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