Penetration of rufloxacin into human prostatic tissue and fluid
The penetration of rufloxacin into prostatic tissue and prostatic fluid was investigated in 16 patients undergoing elective transurethral prostate resection. Rufloxacin 400 mg was given orally approximately 16 h before surgery with a further dose of 200 mg approximately 5 h before surgery. Sampling...
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| Veröffentlicht in: | Journal of antimicrobial chemotherapy 1991-10, Vol.28 (4), p.547-554 |
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| container_issue | 4 |
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| container_title | Journal of antimicrobial chemotherapy |
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| creator | BOEREMA, J. B. J BACH, D JOL, C PAHLMANN, W |
| description | The penetration of rufloxacin into prostatic tissue and prostatic fluid was investigated in 16 patients undergoing elective transurethral prostate resection. Rufloxacin 400 mg was given orally approximately 16 h before surgery with a further dose of 200 mg approximately 5 h before surgery. Sampling was inadequate in three patients. One patient reported transient flushing and headache after the first dose of rufloxacin and was hence withdrawn from the study. In the remaining 12 evaluable patients, the mean ratios of rufloxacin concentrations (determined by HPLC) in prostatic tissue and fluid to the plasma concentration were 1.9 and 1.5, respectively. There were no significant differences between the tissue penetration ratios in different parts of the prostate. The levels of rufloxacin found in prostate tissue and fluid, in this study, exceeded the MICs for most micro-organisms causing chronic bacterial prostatitis. |
| doi_str_mv | 10.1093/jac/28.4.547 |
| format | Article |
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The levels of rufloxacin found in prostate tissue and fluid, in this study, exceeded the MICs for most micro-organisms causing chronic bacterial prostatitis.</description><identifier>ISSN: 0305-7453</identifier><identifier>EISSN: 1460-2091</identifier><identifier>DOI: 10.1093/jac/28.4.547</identifier><identifier>PMID: 1662190</identifier><identifier>CODEN: JACHDX</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adult ; Aged ; Anti-Infective Agents ; Antibacterial agents ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Biological and medical sciences ; Body Fluids - metabolism ; Fluoroquinolones ; Humans ; Male ; Medical sciences ; Middle Aged ; Pharmacology. 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J</creatorcontrib><creatorcontrib>BACH, D</creatorcontrib><creatorcontrib>JOL, C</creatorcontrib><creatorcontrib>PAHLMANN, W</creatorcontrib><title>Penetration of rufloxacin into human prostatic tissue and fluid</title><title>Journal of antimicrobial chemotherapy</title><addtitle>J Antimicrob Chemother</addtitle><description>The penetration of rufloxacin into prostatic tissue and prostatic fluid was investigated in 16 patients undergoing elective transurethral prostate resection. Rufloxacin 400 mg was given orally approximately 16 h before surgery with a further dose of 200 mg approximately 5 h before surgery. Sampling was inadequate in three patients. One patient reported transient flushing and headache after the first dose of rufloxacin and was hence withdrawn from the study. In the remaining 12 evaluable patients, the mean ratios of rufloxacin concentrations (determined by HPLC) in prostatic tissue and fluid to the plasma concentration were 1.9 and 1.5, respectively. There were no significant differences between the tissue penetration ratios in different parts of the prostate. The levels of rufloxacin found in prostate tissue and fluid, in this study, exceeded the MICs for most micro-organisms causing chronic bacterial prostatitis.</description><subject>Adult</subject><subject>Aged</subject><subject>Anti-Infective Agents</subject><subject>Antibacterial agents</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Biological and medical sciences</subject><subject>Body Fluids - metabolism</subject><subject>Fluoroquinolones</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pharmacology. Drug treatments</subject><subject>Prostate - metabolism</subject><subject>Quinolones - blood</subject><subject>Quinolones - pharmacokinetics</subject><subject>Quinolones - urine</subject><issn>0305-7453</issn><issn>1460-2091</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0EtLxDAUBeAgyjiO7twKWYi7zty8k5XI4AsGdKHrkqYpZmjTsUlB_70Fi1tXd3E-DoeL0CWBNQHDNnvrNlSv-VpwdYSWhEsoKBhyjJbAQBSKC3aKzlLaA4AUUi_QgkhJiYElun310efB5tBH3Dd4GJu2_7IuRBxi7vHH2NmID0Of8mQcziGl0WMba9y0Y6jP0Ulj2-Qv5rtC7w_3b9unYvfy-Ly92xUHYnQuKiNrKhuumHGVpopRohQjxoD1FTOVl1proR0zzBmgXoAWjhtZqYrZxiq2Qje_vdOUz9GnXHYhOd-2Nvp-TKWiQhMN9F9IJGhpOJvg1QzHqvN1eRhCZ4fvcn7NlF_PuU3Ots1gowvpjwmiKQfJfgBv_nCl</recordid><startdate>19911001</startdate><enddate>19911001</enddate><creator>BOEREMA, J. B. 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Antiparasitic agents</topic><topic>Biological and medical sciences</topic><topic>Body Fluids - metabolism</topic><topic>Fluoroquinolones</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pharmacology. Drug treatments</topic><topic>Prostate - metabolism</topic><topic>Quinolones - blood</topic><topic>Quinolones - pharmacokinetics</topic><topic>Quinolones - urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BOEREMA, J. B. 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In the remaining 12 evaluable patients, the mean ratios of rufloxacin concentrations (determined by HPLC) in prostatic tissue and fluid to the plasma concentration were 1.9 and 1.5, respectively. There were no significant differences between the tissue penetration ratios in different parts of the prostate. The levels of rufloxacin found in prostate tissue and fluid, in this study, exceeded the MICs for most micro-organisms causing chronic bacterial prostatitis.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>1662190</pmid><doi>10.1093/jac/28.4.547</doi><tpages>8</tpages></addata></record> |
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| ispartof | Journal of antimicrobial chemotherapy, 1991-10, Vol.28 (4), p.547-554 |
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| language | eng |
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| source | MEDLINE; Oxford University Press Journals Digital Archive Legacy |
| subjects | Adult Aged Anti-Infective Agents Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Body Fluids - metabolism Fluoroquinolones Humans Male Medical sciences Middle Aged Pharmacology. Drug treatments Prostate - metabolism Quinolones - blood Quinolones - pharmacokinetics Quinolones - urine |
| title | Penetration of rufloxacin into human prostatic tissue and fluid |
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