Control of MHC Class I Traffic from the Endoplasmic Reticulum by Cellular Chaperones and Viral Anti‐Chaperones

MHC class I molecules assemble with peptides in the endoplasmic reticulum (ER). To ensure that only peptide‐loaded MHC molecules leave the ER, empty molecules are retained by ER‐resident chaperones, most notably the MHC‐specific tapasin. ER exit of class I MHC is also controlled by viruses, but for...

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